Literature DB >> 33922658

Functional Ambivalence of Dendritic Cells: Tolerogenicity and Immunogenicity.

Ji-Hee Nam1, Jun-Ho Lee2, So-Yeon Choi1, Nam-Chul Jung2, Jie-Young Song3, Han-Geuk Seo4, Dae-Seog Lim1.   

Abstract

Dendritic cells (DCs) are the most potent professional antigen-presenting cells (APCs) and inducers of T cell-mediated immunity. Although DCs play a central role in promoting adaptive immune responses against growing tumors, they also establish and maintain peripheral tolerance. DC activity depends on the method of induction and/or the presence of immunosuppressive agents. Tolerogenic dendritic cells (tDCs) induce immune tolerance by activating CD4+CD25+Foxp3+ regulatory T (Treg) cells and/or by producing cytokines that inhibit T cell activation. These findings suggest that tDCs may be an effective treatment for autoimmune diseases, inflammatory diseases, and infertility.

Entities:  

Keywords:  autoimmune disease; dendritic cells; immunotherapy; inflammatory disease; regulatory T cells; tolerogenicity

Year:  2021        PMID： 33922658     DOI： 10.3390/ijms22094430

Source DB:  PubMed          Journal:  Int J Mol Sci        ISSN： 1422-0067            Impact factor:   5.923


  68 in total

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Review 4.  Positive-selection-inducing self-peptides displayed by cortical thymic epithelial cells.

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Journal:  Adv Immunol       Date:  2014-12-24       Impact factor: 3.543

5.  Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology.

Authors:  Holm H Uhlig; Brent S McKenzie; Sophie Hue; Claire Thompson; Barbara Joyce-Shaikh; Renata Stepankova; Nicolas Robinson; Sofia Buonocore; Helena Tlaskalova-Hogenova; Daniel J Cua; Fiona Powrie
Journal:  Immunity       Date:  2006-08       Impact factor: 31.745

6.  Treg depletion potentiates checkpoint inhibition in claudin-low breast cancer.

Authors:  Nicholas A Taylor; Sarah C Vick; Michael D Iglesia; W June Brickey; Bentley R Midkiff; Karen P McKinnon; Shannon Reisdorf; Carey K Anders; Lisa A Carey; Joel S Parker; Charles M Perou; Benjamin G Vincent; Jonathan S Serody
Journal:  J Clin Invest       Date:  2017-08-21       Impact factor: 14.808

Review 7.  Human autoimmune diseases: a comprehensive update.

Authors:  Lifeng Wang; Fu-Sheng Wang; M Eric Gershwin
Journal:  J Intern Med       Date:  2015-07-25       Impact factor: 8.989

8.  In vivo dendritic cell depletion reduces breeding efficiency, affecting implantation and early placental development in mice.

Authors:  Gesa Krey; Pierre Frank; Valerie Shaikly; Gabriela Barrientos; Rosalia Cordo-Russo; Frauke Ringel; Petra Moschansky; Igor V Chernukhin; Metodi Metodiev; Nelson Fernández; Burghard F Klapp; Petra C Arck; Sandra M Blois
Journal:  J Mol Med (Berl)       Date:  2008-06-25       Impact factor: 4.599

Review 9.  Low-density granulocytes: a distinct class of neutrophils in systemic autoimmunity.

Authors:  Carmelo Carmona-Rivera; Mariana J Kaplan
Journal:  Semin Immunopathol       Date:  2013-04-04       Impact factor: 9.623

10.  Generation and characterisation of therapeutic tolerogenic dendritic cells for rheumatoid arthritis.

Authors:  Rachel A Harry; Amy E Anderson; John D Isaacs; Catharien M U Hilkens
Journal:  Ann Rheum Dis       Date:  2010-06-15       Impact factor: 19.103
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  3 in total

1.  Interplay between plasmacytoid dendritic cells and tumor-specific T cells in peripheral blood influences long-term survival in non-small cell lung carcinoma.

Authors:  Caroline Laheurte; Evan Seffar; Eléonore Gravelin; Julie Lecuelle; Adeline Renaudin; Laura Boullerot; Marine Malfroy; Amélie Marguier; Benoit Lecoester; Béatrice Gaugler; Philippe Saas; Caroline Truntzer; Francois Ghiringhelli; Olivier Adotevi
Journal:  Cancer Immunol Immunother       Date:  2022-08-21       Impact factor: 6.630

Review 2.  The Immunomodulatory Functions of Butyrate.

Authors:  Mohamed Tausif Siddiqui; Gail A M Cresci
Journal:  J Inflamm Res       Date:  2021-11-18

3.  β2 Integrins on Dendritic Cells Modulate Cytokine Signaling and Inflammation-Associated Gene Expression, and Are Required for Induction of Autoimmune Encephalomyelitis.

Authors:  Monika Bednarczyk; Vanessa Bolduan; Maximilian Haist; Henner Stege; Christoph Hieber; Lisa Johann; Carsten Schelmbauer; Michaela Blanfeld; Khalad Karram; Jenny Schunke; Tanja Klaus; Ingrid Tubbe; Evelyn Montermann; Nadine Röhrig; Maike Hartmann; Jana Schlosser; Tobias Bopp; Björn E Clausen; Ari Waisman; Matthias Bros; Stephan Grabbe
Journal:  Cells       Date:  2022-07-13       Impact factor: 7.666
  3 in total

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