Literature DB >> 33922480

The Role of Tumor-Derived Exosomes in the Abscopal Effect and Immunotherapy.

Zechen Shan1, Hongmei Wang2, Yujuan Zhang1,2, Weiping Min1,2,3.   

Abstract

Exosomes are microvesicles that can be secreted by various cells and carry a variety of contents; thus, they play multiple biological functions. For instance, the tumor-derived exosomes (TEXs) have been proven to have the effect of immunostimulatory in addition to immunosuppression, making TEXs attractive in clinical immunotherapy and targeted therapy for cancer patients. In addition, TEXs as biomarkers have important clinical diagnostic and prognostic value. Recently, TEXs have been recognized to play important roles in the abscopal effect (AbE), a newly discovered mechanism by which the distant tumors are effectively targeted and repressed during immunotherapy and radiotherapy. Therefore, TEXs has demonstrated great clinical potential in the diagnosis, prognosis and treatment of cancer patients in the future. This review summarizes and discusses the role of TEXs in clinical therapy and their role in AbE in recent studies.

Entities:  

Keywords:  abscopal effect; biomarkers; immunomodulation; radiotherapy; tumor-derived exosomes

Year:  2021        PMID： 33922480     DOI： 10.3390/life11050381

Source DB:  PubMed          Journal:  Life (Basel)        ISSN： 2075-1729


  109 in total

1.  Abnormal lysosomal trafficking and enhanced exosomal export of cisplatin in drug-resistant human ovarian carcinoma cells.

Authors:  Roohangiz Safaei; Barrett J Larson; Timothy C Cheng; Michael A Gibson; Shinji Otani; Wiltrud Naerdemann; Stephen B Howell
Journal:  Mol Cancer Ther       Date:  2005-10       Impact factor: 6.261

2.  Tumor cell-derived exosome-targeted dendritic cells stimulate stronger CD8+ CTL responses and antitumor immunities.

Authors:  Ye Yao; Linjun Chen; Wei Wei; Xiaohui Deng; Liyuan Ma; Siguo Hao
Journal:  Biochem Biophys Res Commun       Date:  2013-05-22       Impact factor: 3.575

3.  microRNAs derived from circulating exosomes as noninvasive biomarkers for screening and diagnosing lung cancer.

Authors:  Riccardo Cazzoli; Fiamma Buttitta; Marta Di Nicola; Sara Malatesta; Antonio Marchetti; William N Rom; Harvey I Pass
Journal:  J Thorac Oncol       Date:  2013-09       Impact factor: 15.609

4.  Experimental model for the irradiation-mediated abscopal effect and factors influencing this effect.

Authors:  Kiichiro Baba; Motoo Nomura; Shinya Ohashi; Takuya Hiratsuka; Yukie Nakai; Tomoki Saito; Yuki Kondo; Keita Fukuyama; Osamu Kikuchi; Atsushi Yamada; Junichi Matsubara; Kenshiro Hirohashi; Yosuke Mitani; Ayaka Mizumoto; Manabu Muto
Journal:  Am J Cancer Res       Date:  2020-02-01       Impact factor: 6.166

Review 5.  The roles of miRNAs as potential biomarkers in lung diseases.

Authors:  Shamila D Alipoor; Ian M Adcock; Johan Garssen; Esmaeil Mortaz; Mohammad Varahram; Mehdi Mirsaeidi; Aliakbar Velayati
Journal:  Eur J Pharmacol       Date:  2016-09-12       Impact factor: 4.432

Review 6.  Radiation-induced bystander and abscopal effects: important lessons from preclinical models.

Authors:  Elisabeth Daguenet; Safa Louati; Anne-Sophie Wozny; Nicolas Vial; Mathilde Gras; Jean-Baptiste Guy; Alexis Vallard; Claire Rodriguez-Lafrasse; Nicolas Magné
Journal:  Br J Cancer       Date:  2020-06-25       Impact factor: 7.640

Review 7.  Exosomes in tumor microenvironment: novel transporters and biomarkers.

Authors:  Zhen Wang; Jun-Qiang Chen; Jin-Lu Liu; Lei Tian
Journal:  J Transl Med       Date:  2016-10-19       Impact factor: 5.531

Review 8.  Dendritic cells loaded with tumor derived exosomes for cancer immunotherapy.

Authors:  Hongyu Liu; Ling Chen; Yaojun Peng; Songyan Yu; Jialin Liu; Liangliang Wu; Lijun Zhang; Qiyan Wu; Xin Chang; Xinguang Yu; Tianyi Liu
Journal:  Oncotarget       Date:  2017-09-11

9.  Improved EGFR mutation detection using combined exosomal RNA and circulating tumor DNA in NSCLC patient plasma.

Authors:  A K Krug; D Enderle; C Karlovich; T Priewasser; S Bentink; A Spiel; K Brinkmann; J Emenegger; D G Grimm; E Castellanos-Rizaldos; J W Goldman; L V Sequist; J-C Soria; D R Camidge; S M Gadgeel; H A Wakelee; M Raponi; M Noerholm; J Skog
Journal:  Ann Oncol       Date:  2018-03-01       Impact factor: 32.976

Review 10.  Enhancing the Bystander and Abscopal Effects to Improve Radiotherapy Outcomes.

Authors:  Virgínea de Araújo Farias; Isabel Tovar; Rosario Del Moral; Francisco O'Valle; José Expósito; Francisco Javier Oliver; José Mariano Ruiz de Almodóvar
Journal:  Front Oncol       Date:  2020-01-08       Impact factor: 6.244
View more
  3 in total

Review 1.  Role of Mitochondria in Radiation Responses: Epigenetic, Metabolic, and Signaling Impacts.

Authors:  Dietrich Averbeck; Claire Rodriguez-Lafrasse
Journal:  Int J Mol Sci       Date:  2021-10-13       Impact factor: 5.923

Review 2.  Tumor-derived exosomes: immune properties and clinical application in lung cancer.

Authors:  Jing Wu; Suyao Li; Pengfei Zhang
Journal:  Cancer Drug Resist       Date:  2022-02-08

Review 3.  Radiotherapy combined with immunotherapy: the dawn of cancer treatment.

Authors:  Zengfu Zhang; Xu Liu; Dawei Chen; Jinming Yu
Journal:  Signal Transduct Target Ther       Date:  2022-07-29
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.