Sławomir Kujawski1, Jo Cossington2, Joanna Słomko1, Monika Zawadka-Kunikowska1, Małgorzata Tafil-Klawe3, Jacek J Klawe1, Katarzyna Buszko4, Djordje G Jakovljevic5, Mariusz Kozakiewicz6, Karl J Morten7, Helen Dawes2,8, James W L Strong7, Modra Murovska9, Jessica Van Oosterwijck10,11, Fernando Estevez-Lopez12, Julia L Newton13, Lynette Hodges14, Paweł Zalewski1. 1. Department of Hygiene, Epidemiology, Ergonomy and Postgraduate Education, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, M. Sklodowskiej-Curie 9, 85-094 Bydgoszcz, Poland. 2. Centre for Movement Occupational and Rehabilitation Sciences, Department of Sport, Health Sciences and Social Work, Oxford Brookes University, Headington Rd, Headington, Oxford OX3 0BP, UK. 3. Department of Human Physiology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Karłowicza 24, 85-092 Bydgoszcz, Poland. 4. Department of Biostatistics and Biomedical Systems Theory, Collegium Medicum, Nicolaus Copernicus University, Jagiellonska Street, 85-067 Bydgoszcz, Poland. 5. Institute of Health and Wellbeing, Faculty of Health and Life Sciences, Priory St, Coventry CV1 5FB, UK. 6. Department of Geriatrics, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, M. Sklodowskiej-Curie 9, 85-094 Bydgoszcz, Poland. 7. Nuffield Department of Women's & Reproductive Health, The Women Centre, University of Oxford, Oxford OX3 9DU, UK. 8. NIHR Oxford Health Biomedical Research Centre, Oxford OX3 7JX, UK. 9. Institute of Microbiology and Virology, Riga Stradiņš University, LV-1067 Riga, Latvia. 10. Department of Rehabilitation Sciences, Ghent University, 9000 Ghent, Belgium. 11. Research Foundation-Flanders (FWO), 1000 Brussels, Belgium. 12. Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC University Medical Center, Postbus 2060, 3000 CB Rotterdam, The Netherlands. 13. Population Health Sciences Institute, The Medical School, Newcastle University, Newcastle-upon-Tyne NE2 4AX, UK. 14. School of Sport, Exercise and Nutrition, Massey University, Palmerston North 4442, New Zealand.
Abstract
BACKGROUND: The therapeutic effects of exercise from structured activity programmes have recently been questioned; as a result, this study examines the impact of an Individualised Activity Program (IAP) on the relationship with cardiovascular, mitochondrial and fatigue parameters. METHODS: Chronic fatigue syndrome (CFS) patients were assessed using Chalder Fatigue Questionnaire (CFQ), Fatigue Severity Score (FSS) and the Fatigue Impact Scale (FIS). VO2peak, VO2submax and heart rate (HR) were assessed using cardiopulmonary exercise testing. Mfn1 and Mfn2 levels in plasma were assessed. A Task Force Monitor was used to assess ANS functioning in supine rest and in response to the Head-Up Tilt Test (HUTT). RESULTS: Thirty-four patients completed 16 weeks of the IAP. The CFQ, FSS and FIS scores decreased significantly along with a significant increase in Mfn1 and Mfn2 levels (p = 0.002 and p = 0.00005, respectively). The relationships between VO2 peak and Mfn1 increase in response to IAP (p = 0.03) and between VO2 at anaerobic threshold and ANS response to the HUTT (p = 0.03) were noted. CONCLUSIONS: It is concluded that IAP reduces fatigue and improves functional performance along with changes in autonomic and mitochondrial function. However, caution must be applied as exercise was not well tolerated by 51% of patients.
BACKGROUND: The therapeutic effects of exercise from structured activity programmes have recently been questioned; as a result, this study examines the impact of an Individualised Activity Program (IAP) on the relationship with cardiovascular, mitochondrial and fatigue parameters. METHODS:Chronic fatigue syndrome (CFS) patients were assessed using Chalder Fatigue Questionnaire (CFQ), Fatigue Severity Score (FSS) and the Fatigue Impact Scale (FIS). VO2peak, VO2submax and heart rate (HR) were assessed using cardiopulmonary exercise testing. Mfn1 and Mfn2 levels in plasma were assessed. A Task Force Monitor was used to assess ANS functioning in supine rest and in response to the Head-Up Tilt Test (HUTT). RESULTS: Thirty-four patients completed 16 weeks of the IAP. The CFQ, FSS and FIS scores decreased significantly along with a significant increase in Mfn1 and Mfn2 levels (p = 0.002 and p = 0.00005, respectively). The relationships between VO2 peak and Mfn1 increase in response to IAP (p = 0.03) and between VO2 at anaerobic threshold and ANS response to the HUTT (p = 0.03) were noted. CONCLUSIONS: It is concluded that IAP reduces fatigue and improves functional performance along with changes in autonomic and mitochondrial function. However, caution must be applied as exercise was not well tolerated by 51% of patients.
Authors: Alba González-Cebrián; Eloy Almenar-Pérez; Jiabao Xu; Tong Yu; Wei E Huang; Karen Giménez-Orenga; Sarah Hutchinson; Tiffany Lodge; Lubov Nathanson; Karl J Morten; Alberto Ferrer; Elisa Oltra Journal: Front Med (Lausanne) Date: 2022-04-01
Authors: Xiaoyu Che; Christopher R Brydges; Yuanzhi Yu; Adam Price; Shreyas Joshi; Ayan Roy; Bohyun Lee; Dinesh K Barupal; Aaron Cheng; Dana March Palmer; Susan Levine; Daniel L Peterson; Suzanne D Vernon; Lucinda Bateman; Mady Hornig; Jose G Montoya; Anthony L Komaroff; Oliver Fiehn; W Ian Lipkin Journal: Int J Mol Sci Date: 2022-07-18 Impact factor: 6.208