Literature DB >> 33915154

Get SET Early to Identify and Treatment Refer Autism Spectrum Disorder at 1 Year and Discover Factors That Influence Early Diagnosis.

Karen Pierce1, Vahid Gazestani2, Elizabeth Bacon3, Eric Courchesne3, Amanda Cheng3, Cynthia Carter Barnes3, Srinivasa Nalabolu3, Debra Cha3, Steven Arias3, Linda Lopez3, Christie Pham3, Kim Gaines4, Gohar Gyurjyan4, Terri Cook-Clark4, Kathy Karins4.   

Abstract

OBJECTIVES: To examine the impact of a new approach, Get SET Early, on the rates of early autism spectrum disorder (ASD) detection and factors that influence the screen-evaluate-treat chain. STUDY
DESIGN: Following Get SET Early training, 203 pediatricians administered 57,603 total screens using the Communication and Symbolic Behavior Scales Infant-Toddler Checklist at 12, 18, and 24-month well-baby examinations, and parents designated presence or absence of concern. For screen-positive toddlers, pediatricians specified if the child was being referred for evaluation, and if not, why not.
RESULTS: Collapsed across ages, toddlers were evaluated and referred for treatment at a median age of 19 months, and those screened at 12 months (59.4% of sample) by 15 months. Pediatricians referred one-third of screen-positive toddlers for evaluation, citing lack of confidence in the accuracy of screen-positive results as the primary reason for non-referral. If a parent expressed concerns, referral probability doubled, and the rate of an ASD diagnosis increased 37%. Of 897 toddlers evaluated, almost half were diagnosed as ASD, translating into an ASD prevalence of 1%.
CONCLUSIONS: The Get SET Early model was effective at detecting ASD and initiating very early treatment. Results also underscored the need for change in early identification approaches to formally operationalize and incorporate pediatrician judgement and level of parent concern into the process.
Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Screening; autism; diagnosis; early detection

Year:  2021        PMID: 33915154     DOI: 10.1016/j.jpeds.2021.04.041

Source DB:  PubMed          Journal:  J Pediatr        ISSN: 0022-3476            Impact factor:   4.406


  8 in total

1.  Future Prospects for Epigenetics in Autism Spectrum Disorder.

Authors:  Logan A Williams; Janine M LaSalle
Journal:  Mol Diagn Ther       Date:  2022-08-13       Impact factor: 4.476

2.  Neural responses to affective speech, including motherese, map onto clinical and social eye tracking profiles in toddlers with ASD.

Authors:  Yaqiong Xiao; Teresa H Wen; Lauren Kupis; Lisa T Eyler; Disha Goel; Keith Vaux; Michael V Lombardo; Nathan E Lewis; Karen Pierce; Eric Courchesne
Journal:  Nat Hum Behav       Date:  2022-01-03

3.  A predictive ensemble classifier for the gene expression diagnosis of ASD at ages 1 to 4 years.

Authors:  Bokan Bao; Javad Zahiri; Vahid H Gazestani; Linda Lopez; Yaqiong Xiao; Raphael Kim; Teresa H Wen; Austin W T Chiang; Srinivasa Nalabolu; Karen Pierce; Kimberly Robasky; Tianyun Wang; Kendra Hoekzema; Evan E Eichler; Nathan E Lewis; Eric Courchesne
Journal:  Mol Psychiatry       Date:  2022-10-20       Impact factor: 13.437

4.  Early Identification of Autism Spectrum Disorder Among Children Aged 4 Years - Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2018.

Authors:  Kelly A Shaw; Matthew J Maenner; Amanda V Bakian; Deborah A Bilder; Maureen S Durkin; Sarah M Furnier; Michelle M Hughes; Mary Patrick; Karen Pierce; Angelica Salinas; Josephine Shenouda; Alison Vehorn; Zachary Warren; Walter Zahorodny; John N Constantino; Monica DiRienzo; Amy Esler; Robert T Fitzgerald; Andrea Grzybowski; Allison Hudson; Margaret H Spivey; Akilah Ali; Jennifer G Andrews; Thaer Baroud; Johanna Gutierrez; Libby Hallas; Jennifer Hall-Lande; Amy Hewitt; Li-Ching Lee; Maya Lopez; Kristen Clancy Mancilla; Dedria McArthur; Sydney Pettygrove; Jenny N Poynter; Yvette D Schwenk; Anita Washington; Susan Williams; Mary E Cogswell
Journal:  MMWR Surveill Summ       Date:  2021-12-03

5.  Atypical genomic cortical patterning in autism with poor early language outcome.

Authors:  Michael V Lombardo; Lisa Eyler; Tiziano Pramparo; Vahid H Gazestani; Donald J Hagler; Chi-Hua Chen; Anders M Dale; Jakob Seidlitz; Richard A I Bethlehem; Natasha Bertelsen; Cynthia Carter Barnes; Linda Lopez; Kathleen Campbell; Nathan E Lewis; Karen Pierce; Eric Courchesne
Journal:  Sci Adv       Date:  2021-09-03       Impact factor: 14.136

6.  Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 8 Years - Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2018.

Authors:  Matthew J Maenner; Kelly A Shaw; Amanda V Bakian; Deborah A Bilder; Maureen S Durkin; Amy Esler; Sarah M Furnier; Libby Hallas; Jennifer Hall-Lande; Allison Hudson; Michelle M Hughes; Mary Patrick; Karen Pierce; Jenny N Poynter; Angelica Salinas; Josephine Shenouda; Alison Vehorn; Zachary Warren; John N Constantino; Monica DiRienzo; Robert T Fitzgerald; Andrea Grzybowski; Margaret H Spivey; Sydney Pettygrove; Walter Zahorodny; Akilah Ali; Jennifer G Andrews; Thaer Baroud; Johanna Gutierrez; Amy Hewitt; Li-Ching Lee; Maya Lopez; Kristen Clancy Mancilla; Dedria McArthur; Yvette D Schwenk; Anita Washington; Susan Williams; Mary E Cogswell
Journal:  MMWR Surveill Summ       Date:  2021-12-03

7.  Predictive validity of the Infant Toddler Checklist in primary care at the 18-month visit and developmental diagnosis at 3-5 years: a prospective cohort study.

Authors:  Cornelia M Borkhoff; Marina Atalla; Imaan Bayoumi; Catherine S Birken; Jonathon L Maguire; Patricia C Parkin
Journal:  BMJ Paediatr Open       Date:  2022-06

8.  Large scale validation of an early-age eye-tracking biomarker of an autism spectrum disorder subtype.

Authors:  Teresa H Wen; Amanda Cheng; Charlene Andreason; Javad Zahiri; Yaqiong Xiao; Ronghui Xu; Bokan Bao; Eric Courchesne; Cynthia Carter Barnes; Steven J Arias; Karen Pierce
Journal:  Sci Rep       Date:  2022-03-11       Impact factor: 4.379

  8 in total

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