| Literature DB >> 33915111 |
Matthew R Zanotelli1, Jian Zhang2, Cynthia A Reinhart-King3.
Abstract
Altered tissue mechanics and metabolism are defining characteristics of cancer that impact not only proliferation but also migration. While migrating through a mechanically and spatially heterogeneous microenvironment, changes in metabolism allow cells to dynamically tune energy generation and bioenergetics in response to fluctuating energy needs. Physical cues from the extracellular matrix influence mechanosignaling pathways, cell mechanics, and cytoskeletal architecture to alter presentation and function of metabolic enzymes. In cancer, altered mechanosensing and metabolic reprogramming supports metabolic plasticity and high energy production while cells migrate and metastasize. Here, we discuss the role of mechanoresponsive metabolism in regulating cell migration and supporting metastasis as well as the potential of therapeutically targeting cancer metabolism to block motility and potentially metastasis.Entities:
Keywords: bioenergetics; cancer invasion; energy metabolism; mechanotransduction; tumor microenvironment
Mesh：
Year: 2021 PMID： 33915111 PMCID： PMC9015673 DOI： 10.1016/j.cmet.2021.04.002
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 31.373