Nabihah Haron1, Senthilmani Rajendran1, Thomas George Kallarakkal2,3, Rosnah Binti Zain2,3,4, Anand Ramanathan2,3, Mannil Thomas Abraham5,6, Shin Hin Lau7, Lai Choo Cheng6, Sherrie Mei Yee Chong5,6, Farah Aliya Mohamed Azahar6,8, Zuraiza Mohamad Zaini2, Siew Wui Chan2, Yet Ching Goh2, Daniel Lim2, Juliana Khairi5,6, Marzuki Zainal Abidin6,8, Zainal Ariff Abdul Rahman2, Chee Sun Liew9,10,11, Siew Chinn Fong1, Yi-Hsin Yang12, Siti Mazlipah Ismail2, Sok Ching Cheong1,2. 1. Cancer Research Malaysia, Selangor, Malaysia. 2. Department of Oral and Maxillofacial Clinical Sciences, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia. 3. Oral Cancer Research & Coordinating Centre (OCRCC), Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia. 4. Faculty of Dentistry, Saujana Putra Campus, MAHSA University, Selangor, Malaysia. 5. Department of Oral and Maxillofacial Surgery, Hospital Tengku Ampuan Rahimah, Ministry of Health, Selangor, Malaysia. 6. Oral Health Program, Ministry of Health Malaysia, Putrajaya, Malaysia. 7. Institute for Medical Research, Kuala Lumpur, Malaysia. 8. Oral Surgery Clinic, Hospital Serdang, Ministry of Health, Serdang, Malaysia. 9. Department of Computer System & Technology, Faculty of Computer Science & Information Technology, University of Malaya, Kuala Lumpur, Malaysia. 10. Data Intensive Computing Centre, Research Management & Innovation Complex, University of Malaya, Kuala Lumpur, Malaysia. 11. Centre for Data Science, University of Malaya, Kuala Lumpur, Malaysia. 12. National Institute of Cancer Research, National Health Research Institutes, Tainan, Malaysia.
Abstract
OBJECTIVE: To evaluate the accuracy of MeMoSA®, a mobile phone application to review images of oral lesions in identifying oral cancers and oral potentially malignant disorders requiring referral. SUBJECTS AND METHODS: A prospective study of 355 participants, including 280 with oral lesions/variants was conducted. Adults aged ≥18 treated at tertiary referral centres were included. Images of the oral cavity were taken using MeMoSA®. The identification of the presence of lesion/variant and referral decision made using MeMoSA® were compared to clinical oral examination, using kappa statistics for intra-rater agreement. Sensitivity, specificity, concordance and F1 score were computed. Images were reviewed by an off-site specialist and inter-rater agreement was evaluated. Images from sequential clinical visits were compared to evaluate observable changes in the lesions. RESULTS: Kappa values comparing MeMoSA® with clinical oral examination in detecting a lesion and referral decision was 0.604 and 0.892, respectively. Sensitivity and specificity for referral decision were 94.0% and 95.5%. Concordance and F1 score were 94.9% and 93.3%, respectively. Inter-rater agreement for a referral decision was 0.825. Progression or regression of lesions were systematically documented using MeMoSA®. CONCLUSION: Referral decisions made through MeMoSA® is highly comparable to clinical examination demonstrating it is a reliable telemedicine tool to facilitate the identification of high-risk lesions for early management.
OBJECTIVE: To evaluate the accuracy of MeMoSA®, a mobile phone application to review images of oral lesions in identifying oral cancers and oral potentially malignant disorders requiring referral. SUBJECTS AND METHODS: A prospective study of 355 participants, including 280 with oral lesions/variants was conducted. Adults aged ≥18 treated at tertiary referral centres were included. Images of the oral cavity were taken using MeMoSA®. The identification of the presence of lesion/variant and referral decision made using MeMoSA® were compared to clinical oral examination, using kappa statistics for intra-rater agreement. Sensitivity, specificity, concordance and F1 score were computed. Images were reviewed by an off-site specialist and inter-rater agreement was evaluated. Images from sequential clinical visits were compared to evaluate observable changes in the lesions. RESULTS: Kappa values comparing MeMoSA® with clinical oral examination in detecting a lesion and referral decision was 0.604 and 0.892, respectively. Sensitivity and specificity for referral decision were 94.0% and 95.5%. Concordance and F1 score were 94.9% and 93.3%, respectively. Inter-rater agreement for a referral decision was 0.825. Progression or regression of lesions were systematically documented using MeMoSA®. CONCLUSION: Referral decisions made through MeMoSA® is highly comparable to clinical examination demonstrating it is a reliable telemedicine tool to facilitate the identification of high-risk lesions for early management.
Authors: Tanya Walsh; Saman Warnakulasuriya; Mark W Lingen; Alexander R Kerr; Graham R Ogden; Anne-Marie Glenny; Richard Macey Journal: Cochrane Database Syst Rev Date: 2021-12-10
Authors: Mary E Northridge; Kera F Weiserbs; Shabnam Seyedzadeh Sabounchi; Andrea Torroni; Nathalie S Mohadjeri-Franck; Steven Gargano; Eliot George; Tina C Littlejohn; Andrea B Troxel; Yinxiang Wu; Paul A Testa; Jennifer Wismer; Kiah Zaremba; Peter Tylawsky; Babak Bina Journal: J Public Health Res Date: 2022-08-30