Ahmed Abdel Khalek Abdel Razek1, Mona Mohamed Hafez2, Walaa Mahmoud3, Ahmed Ramadan Ismail4, Khadiga M Ali5, Tarek Elsayed Barakat4. 1. Department of Diagnostic Radiology, Mansoura Faculty of Medicine, Mansoura University, Mansoura, 13551, Egypt. arazek@mans.edu.eg. 2. Cardiology Unit, Department of Pediatrics, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt. 3. Department of Diagnostic Radiology, Mansoura Faculty of Medicine, Mansoura University, Mansoura, 13551, Egypt. 4. Gastroenterology and Hepatology Unit, Department of Pediatrics, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt. 5. Department of Pathology, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Abstract
PURPOSE: To assess diffusion tensor imaging (DTI) of spleen in prediction and grading of esophageal varices (OV) in cirrhotic children. METHODS: This prospective study was conducted upon 30 children with cirrhotic children with OV and 10 age-gender matched controls that underwent DTI of abdomen. Mean diffusivity (MD) and fractional anisotropy (FA) of spleen were calculated and matched with the grading of OV at endoscopy and laboratory biomarkers of portal hypertension. RESULTS: Mean ADC of spleen in patient was significantly different (p = 0.001) from that of controls by both reviewers respectively. The cutoff ADC measurement of the spleen used for prediction of OV was ≥ 0.75 and ≥ 0.76 × 10-3mm2/s with AUC was 0.993 and 0.997 for both reviewers respectively. The FA of the spleen in patient was different (p = 0.01) from of controls of both reviewers respectively. Cutoff FA of spleen used for prediction of OV was ≤ 0.35 and ≤ 0.36 for both observers respectively. ADC and FA of spleen was correlated with platelets count (r = - 0.713, 0.392; p = 0.001, 0.012) and prothrombin time (r = 0.518, - 0.380; p = 0.001, 0.016). CONCLUSION: DTI metrics of spleen can predict and grade OV and correlated with laboratory biomarkers of portal hypertension.
PURPOSE: To assess diffusion tensor imaging (DTI) of spleen in prediction and grading of esophageal varices (OV) in cirrhotic children. METHODS: This prospective study was conducted upon 30 children with cirrhotic children with OV and 10 age-gender matched controls that underwent DTI of abdomen. Mean diffusivity (MD) and fractional anisotropy (FA) of spleen were calculated and matched with the grading of OV at endoscopy and laboratory biomarkers of portal hypertension. RESULTS: Mean ADC of spleen in patient was significantly different (p = 0.001) from that of controls by both reviewers respectively. The cutoff ADC measurement of the spleen used for prediction of OV was ≥ 0.75 and ≥ 0.76 × 10-3mm2/s with AUC was 0.993 and 0.997 for both reviewers respectively. The FA of the spleen in patient was different (p = 0.01) from of controls of both reviewers respectively. Cutoff FA of spleen used for prediction of OV was ≤ 0.35 and ≤ 0.36 for both observers respectively. ADC and FA of spleen was correlated with platelets count (r = - 0.713, 0.392; p = 0.001, 0.012) and prothrombin time (r = 0.518, - 0.380; p = 0.001, 0.016). CONCLUSION: DTI metrics of spleen can predict and grade OV and correlated with laboratory biomarkers of portal hypertension.
Authors: Noelle H Ebel; Kristen Carlin; Michele L Shaffer; Giri Shivaram; Matthew Hawkins; Erin R Lane; Kara Cooper; Will S Lindquester; Gaurav Gadodia; Karen F Murray Journal: J Pediatr Gastroenterol Nutr Date: 2019-06 Impact factor: 2.839
Authors: Júlio R Pimenta; Alexandre R Ferreira; Eleonora D T Fagundes; Thaís C N Queiroz; Regiane A N Baptista; Eduardo G de Araújo Moreira; Camilo B de Resende; Paulo F S Bittencourt; Simone D Carvalho; José A F Neto; Francisco J Penna Journal: J Pediatr Gastroenterol Nutr Date: 2017-02 Impact factor: 2.839