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Literature DB >> 3391227

Indomethacin and cerebral blood flow in premature infants treated for patent ductus arteriosus.

Abstract

Central blood flow (CBF) was estimated by an intravenous 133-xenon technique in six preterm infants before and after administration of indomethacin for closure of patent ductus arteriosus. CBF fell in all infants (range 12%-40%), the mean fall was 24% (P less than 0.005). Though none of the infants showed signs of impaired cerebral function during or following the injections, the results do not indicate whether or not the use of indomethacin is a potential hazard.

Entities: Chemical Disease Species

Mesh：

Substances：
Indomethacin

Year: 1988 PMID： 3391227 DOI： 10.1007/bf00442705

Source DB: PubMed Journal: Eur J Pediatr ISSN： 0340-6199 Impact factor: 3.183

7 in total

1. Regional cerebral blood flow estimated by 133-xenon inhalation.

Authors: W D Obrist; H K Thompson; H S Wang; W E Wilkinson
Journal: Stroke Date: 1975 May-Jun Impact factor: 7.914

2. Cerebral blood flow in preterm infants during the first week of life.

Authors: G Greisen
Journal: Acta Paediatr Scand Date: 1986-01

3. Indomethacin, patent ductus arteriosus, and cerebral blood flow.

Authors: F Cowan
Journal: J Pediatr Date: 1986-08 Impact factor: 4.406

4. The effect of indomethacin on the blood flow-metabolism couple in the brain under normal, hypercapnic and hypoxic conditions.

Authors: T Sakabe; B K Siesjö
Journal: Acta Physiol Scand Date: 1979-11

Review 5. Participation of prostaglandins in the regulation of peripheral vascular resistance.

Authors: A Wennmalm
Journal: Adv Prostaglandin Thromboxane Leukot Res Date: 1982

6. Local cerebral circulatory and metabolic effects of indomethacin.

Authors: J McCulloch; P A Kelly; J J Grome; J D Pickard
Journal: Am J Physiol Date: 1982-09

7. The effect of patent ductus arteriosus on flow velocity in the anterior cerebral arteries: ductal steal in the premature newborn infant.

Authors: J M Perlman; A Hill; J J Volpe
Journal: J Pediatr Date: 1981-11 Impact factor: 4.406

7 in total

13 in total

Review 1. Patent ductus arteriousus in the premature neonate: current concepts in pharmacological management.

Authors: C Hammerman; M Kaplan
Journal: Paediatr Drugs Date: 1999 Apr-Jun Impact factor: 3.022

2. Development of audit measures and guidelines for good practice in the management of neonatal respiratory distress syndrome. Report of a Joint Working Group of the British Association of Perinatal Medicine and the Research Unit of the Royal College of Physicians.

Authors:
Journal: Arch Dis Child Date: 1992-10 Impact factor: 3.791

10. Effects of repeated indomethacin administration on cerebral oxygenation and haemodynamics in preterm infants: combined near infrared spectrophotometry and Doppler ultrasound study.

Authors: K D Liem; J C Hopman; L A Kollée; B Oeseburg
Journal: Eur J Pediatr Date: 1994-07 Impact factor: 3.183

Indomethacin and cerebral blood flow in premature infants treated for patent ductus arteriosus.

1. Regional cerebral blood flow estimated by 133-xenon inhalation.

2. Cerebral blood flow in preterm infants during the first week of life.

3. Indomethacin, patent ductus arteriosus, and cerebral blood flow.

4. The effect of indomethacin on the blood flow-metabolism couple in the brain under normal, hypercapnic and hypoxic conditions.

Review 5. Participation of prostaglandins in the regulation of peripheral vascular resistance.

6. Local cerebral circulatory and metabolic effects of indomethacin.

7. The effect of patent ductus arteriosus on flow velocity in the anterior cerebral arteries: ductal steal in the premature newborn infant.

Review 1. Patent ductus arteriousus in the premature neonate: current concepts in pharmacological management.

2. Development of audit measures and guidelines for good practice in the management of neonatal respiratory distress syndrome. Report of a Joint Working Group of the British Association of Perinatal Medicine and the Research Unit of the Royal College of Physicians.

3. Cerebral blood flow and indomethacin drug levels in subjects with and without central nervous side effects.

Review 4. Cerebral blood flow in the newborn infant.

Review 5. Evidence-based use of indomethacin and ibuprofen in the neonatal intensive care unit.

Review 6. Patent ductus arteriosus: are current neonatal treatment options better or worse than no treatment at all?

7. Cerebral autoregulation in neonates with a hemodynamically significant patent ductus arteriosus.

8. Effect of infusion rate of indomethacin on cerebrovascular responses in preterm neonates.

9. The effect of phenobarbital on cerebral blood flow in newborn infants with foetal distress.

10. Effects of repeated indomethacin administration on cerebral oxygenation and haemodynamics in preterm infants: combined near infrared spectrophotometry and Doppler ultrasound study.