Literature DB >> 33911989

It is not just artemisinin: Artemisia sp. for treating diseases including malaria and schistosomiasis.

B M Gruessner1, L Cornet-Vernet2, M R Desrosiers1, P Lutgen3, M J Towler1, P J Weathers1.   

Abstract

Artemisia sp., especially A. annua and A. afra, have been used for centuries to treat many ailments. While artemisinin is the main therapeutically active component, emerging evidence demonstrates that the other phytochemicals in this genus are also therapeutically active. Those compounds include flavonoids, other terpenes, coumarins, and phenolic acids. Artemisia sp. phytochemicals also improve bioavailability of artemisinin and synergistically improve artemisinin therapeutic efficacy, especially when delivered as dried leaf Artemisia as a tea infusion or as powdered dry leaves in a capsule or compressed into a tablet. Here results from in vitro, and in vivo animal and human studies are summarized and critically discussed for mainly malaria, but also other diseases susceptible to artemisinin and Artemisia sp. including schistosomiasis, leishmaniasis, and trypanosomiasis.

Entities:  

Keywords:  Artemisia annua and Artemisia afra; Artemisinin resistance; Bioavailability; Leishmaniasis; Malaria; Schistosomiasis; Trypanosomiasis

Year:  2019        PMID: 33911989      PMCID: PMC8078015          DOI: 10.1007/s11101-019-09645-9

Source DB:  PubMed          Journal:  Phytochem Rev        ISSN: 1568-7767            Impact factor:   5.374


  99 in total

Review 1.  Leishmaniasis impact and treatment access.

Authors:  M den Boer; D Argaw; J Jannin; J Alvar
Journal:  Clin Microbiol Infect       Date:  2011-10       Impact factor: 8.067

2.  Use of saliva and capillary blood samples as substitutes for venous blood sampling in pharmacokinetic investigations of artemisinin.

Authors:  T Gordi; T N Hai; N M Hoai; M Thyberg; M Ashton
Journal:  Eur J Clin Pharmacol       Date:  2000-11       Impact factor: 2.953

3.  Flavonoids casticin and chrysosplenol D from Artemisia annua L. inhibit inflammation in vitro and in vivo.

Authors:  Yu-Jie Li; Yan Guo; Qing Yang; Xiao-Gang Weng; Lan Yang; Ya-Jie Wang; Ying Chen; Dong Zhang; Qi Li; Xu-Cen Liu; Xiao-Xi Kan; Xi Chen; Xiao-Xin Zhu; Eva Kmoníèková; Zdenìk Zídek
Journal:  Toxicol Appl Pharmacol       Date:  2015-04-17       Impact factor: 4.219

4.  In vitro susceptibility of Plasmodium falciparum Welch field isolates to infusions prepared from Artemisia annua L. cultivated in the Brazilian Amazon.

Authors:  Luiz Francisco Rocha e Silva; Pedro Melillo de Magalhães; Mônica Regina Farias Costa; Maria das Graças Costa Alecrim; Francisco Célio Maia Chaves; Ari de Freitas Hidalgo; Adrian Martin Pohlit; Pedro Paulo Ribeiro Vieira
Journal:  Mem Inst Oswaldo Cruz       Date:  2012-11       Impact factor: 2.743

5.  A major genome region underlying artemisinin resistance in malaria.

Authors:  Ian H Cheeseman; Becky A Miller; Shalini Nair; Standwell Nkhoma; Asako Tan; John C Tan; Salma Al Saai; Aung Pyae Phyo; Carit Ler Moo; Khin Maung Lwin; Rose McGready; Elizabeth Ashley; Mallika Imwong; Kasia Stepniewska; Poravuth Yi; Arjen M Dondorp; Mayfong Mayxay; Paul N Newton; Nicholas J White; François Nosten; Michael T Ferdig; Timothy J C Anderson
Journal:  Science       Date:  2012-04-06       Impact factor: 47.728

6.  Inhibiting the Plasmodium eIF2α Kinase PK4 Prevents Artemisinin-Induced Latency.

Authors:  Min Zhang; Julio Gallego-Delgado; Cristina Fernandez-Arias; Norman C Waters; Ana Rodriguez; Moriya Tsuji; Ronald C Wek; Victor Nussenzweig; William J Sullivan
Journal:  Cell Host Microbe       Date:  2017-12-13       Impact factor: 21.023

7.  Changes in key constituents of clonally propagated Artemisia annua L. during preparation of compressed leaf tablets for possible therapeutic use.

Authors:  Pamela J Weathers; Melissa J Towler
Journal:  Ind Crops Prod       Date:  2014-12-01       Impact factor: 5.645

Review 8.  Human malarial disease: a consequence of inflammatory cytokine release.

Authors:  Ian A Clark; Alison C Budd; Lisa M Alleva; William B Cowden
Journal:  Malar J       Date:  2006-10-10       Impact factor: 2.979

9.  Population pharmacokinetic properties of artemisinin in healthy male Vietnamese volunteers.

Authors:  Sofia Birgersson; Pham Van Toi; Nguyen Thanh Truong; Nguyen Thi Dung; Michael Ashton; Tran Tinh Hien; Angela Abelö; Joel Tarning
Journal:  Malar J       Date:  2016-02-16       Impact factor: 2.979

10.  Commercial drugs containing flavonoids are active in mice with malaria and in vitro against chloroquine-resistant Plasmodium falciparum.

Authors:  Julia Penna-Coutinho; Anna Cc Aguiar; Antoniana Ursine Krettli/
Journal:  Mem Inst Oswaldo Cruz       Date:  2018-12-06       Impact factor: 2.743

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  2 in total

1.  Variability in the Chemical Composition of a New Aromatic Plant Artemisia balchanorum in Southern Russia.

Authors:  Gennadii V Khodakov; Lavr A Kryukov; Einat Shemesh-Mayer; Rina Kamenetsky-Goldstein
Journal:  Plants (Basel)       Date:  2021-12-21

Review 2.  Enhancing artemisinin content in and delivery from Artemisia annua: a review of alternative, classical, and transgenic approaches.

Authors:  Kaiser Iqbal Wani; Sadaf Choudhary; Andleeb Zehra; M Naeem; Pamela Weathers; Tariq Aftab
Journal:  Planta       Date:  2021-07-15       Impact factor: 4.116

  2 in total

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