Takayuki Sugiyama1, Hiroshi Terada2, Hideaki Miyake2. 1. Department of Urology, Hamamatsu University School of Medicine, Hamamatsu, Japan taka0311@hama-med.ac.jp. 2. Department of Urology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Abstract
BACKGROUND/AIM: The objective of this study was to investigate the significance of the blood levels of free amino acids (AAs) in infertile men. PATIENTS AND METHODS: Ninety-three men who underwent examinations for infertility were included. The concentrations of 20 AAs were measured and compared in four groups (normospermia, obstructive azoospermia, oligozoospermia, non-obstructive azoospermia) based on semen analysis and clinical parameters. RESULTS: When the 93 men were divided into normospermia, obstructive azoospermia, oligozoospermia, and non-obstructive azoospermia groups, no significant differences were found in the concentrations of the 20 AAs between them. We then compared 49 men diagnosed with normozoospermia or oligozoospermia according to the median sperm motility and morphology abnormalities rates (30% and 20%, respectively). Men with low motility rates had significantly lower levels of tryptophan and alanine, and men with high abnormal morphology rates had significantly lower levels of aspartate and glutamate. CONCLUSION: AAs are probably involved in the pathogenesis of male infertility, particularly oligozoospermia. Copyright
BACKGROUND/AIM: The objective of this study was to investigate the significance of the blood levels of free amino acids (AAs) in infertilemen. PATIENTS AND METHODS: Ninety-three men who underwent examinations for infertility were included. The concentrations of 20 AAs were measured and compared in four groups (normospermia, obstructive azoospermia, oligozoospermia, non-obstructive azoospermia) based on semen analysis and clinical parameters. RESULTS: When the 93 men were divided into normospermia, obstructive azoospermia, oligozoospermia, and non-obstructive azoospermia groups, no significant differences were found in the concentrations of the 20 AAs between them. We then compared 49 men diagnosed with normozoospermia or oligozoospermia according to the median sperm motility and morphology abnormalities rates (30% and 20%, respectively). Men with low motility rates had significantly lower levels of tryptophan and alanine, and men with high abnormal morphology rates had significantly lower levels of aspartate and glutamate. CONCLUSION:AAs are probably involved in the pathogenesis of male infertility, particularly oligozoospermia. Copyright
Authors: Federica Murgia; Valentina Corda; Marianna Serrenti; Valeria Usai; Maria Laura Santoru; K Joseph Hurt; Mauro Passaretti; Maria Carla Monni; Luigi Atzori; Giovanni Monni Journal: Metabolites Date: 2020-02-11