Tomás Rodrigues Magalhães1, Ana Luísa Lourenço2,3, Hugo Gregório4, Felisbina Luísa Queiroga5,6,7. 1. Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal. 2. Department of Animal Science, University of Trás-os-Montes e Alto Douro, Vila Real, Portugal. 3. Animal and Veterinary Research Centre (CECAV), University of Trás-os-Montes e Alto Douro, Vila Real, Portugal. 4. AniCura Centro Hospitalar Veterinário, Porto, Portugal. 5. Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal; fqueirog@utad.pt. 6. Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro, Vila Real, Portugal. 7. Center for the Study of Animal Sciences, CECA-ICETA, University of Porto, Porto, Portugal.
Abstract
BACKGROUND/AIM: The aim of this study is to identify and describe randomized controlled studies evaluating the therapeutic effect of EPA and DHA supplementation in companion animal diseases. MATERIALS AND METHODS: A systematic search was conducted in PubMed database and the information collected was summarized and evaluated according to the risk of bias, using the revised Cochrane tool (RoB2). RESULTS: Twenty-three studies were eligible for inclusion: twenty performed in dogs and three in cats. A therapeutic benefit was found in canine allergic dermatitis, haircoat disorder, keratoconjunctivitis sicca, valvular disease, and canine and feline osteoarthritis. Dogs diagnosed with chronic heart failure and lymphoma and cats with allergic dermatitis also seem to benefit from supplementation with omega-3 fatty acids, but studies with improved methodological quality are needed to strengthen this evidence. CONCLUSION: EPA and DHA supplementation has proven benefits in the adjuvant treatment of various neoplastic and non-neoplastic diseases in dogs and cats. Copyright
BACKGROUND/AIM: The aim of this study is to identify and describe randomized controlled studies evaluating the therapeutic effect of EPA and DHA supplementation in companion animal diseases. MATERIALS AND METHODS: A systematic search was conducted in PubMed database and the information collected was summarized and evaluated according to the risk of bias, using the revised Cochrane tool (RoB2). RESULTS: Twenty-three studies were eligible for inclusion: twenty performed in dogs and three in cats. A therapeutic benefit was found in canine allergic dermatitis, haircoat disorder, keratoconjunctivitis sicca, valvular disease, and canine and feline osteoarthritis. Dogs diagnosed with chronic heart failure and lymphoma and cats with allergic dermatitis also seem to benefit from supplementation with omega-3 fatty acids, but studies with improved methodological quality are needed to strengthen this evidence. CONCLUSION: EPA and DHA supplementation has proven benefits in the adjuvant treatment of various neoplastic and non-neoplastic diseases in dogs and cats. Copyright
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