Xiao-Cheng Wang1,2, Ya Liu3, Fei-Wu Long4, Liang-Ren Liu2, Chuan-Wen Fan4,5. 1. Department of Day Surgery Center, West China Hospital, Sichuan University, Chengdu, 610041, China. 2. Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China. 3. Department of Internal Medicine, Chengdu City Jinniu District No. 2 People's Hospital, Chengdu, 610036, China. 4. Department of Gastrointestinal Surgery & Breast & Thyroid Surgery, Minimally Invasive Surgery, West China School of Public Health & West China Fourth Hospital, Sichuan University, Chengdu, 610041, China. 5. Department of Oncology & Department of Biomedical & Clinical Sciences, Linköping University, Linköping, 58183, Sweden.
Abstract
Background: The relationship between long noncoding RNAs (lncRNAs) and the mRNA stemness index (mRNAsi) in colorectal cancer (CRC) is still unclear. Materials & methods: The mRNAsi, mRNAsi-related lncRNAs and their clinical significance were analyzed by bioinformatic approaches in The Cancer Genome Atlas (TCGA)-COREAD dataset. Results: mRNAsi was negatively related to pathological features but positively related to overall survival and recurrence-free survival in CRC. A five mRNAsi-related lncRNAs prognostic signature was further developed and showed independent prognostic factors related to overall survival in CRC patients, due to the five mRNAsi-related lncRNAs involved in several pathways of the cancer stem cells and malignant cancer cell phenotypes. Conclusion: The present study highlights the potential roles of mRNAsi-related lncRNAs as alternative prognostic markers.
Background: The relationship between long noncoding RNAs (lncRNAs) and the mRNA stemness index (mRNAsi) in colorectal cancer (CRC) is still unclear. Materials & methods: The mRNAsi, mRNAsi-related lncRNAs and their clinical significance were analyzed by bioinformatic approaches in The Cancer Genome Atlas (TCGA)-COREAD dataset. Results: mRNAsi was negatively related to pathological features but positively related to overall survival and recurrence-free survival in CRC. A five mRNAsi-related lncRNAs prognostic signature was further developed and showed independent prognostic factors related to overall survival in CRC patients, due to the five mRNAsi-related lncRNAs involved in several pathways of the cancer stem cells and malignant cancer cell phenotypes. Conclusion: The present study highlights the potential roles of mRNAsi-related lncRNAs as alternative prognostic markers.
Entities:
Keywords:
cancer stem cells; colorectal cancer; lncRNAs; mRNAsi; prognosis