Outcomes of major trauma among patients with chronic kidney disease and receiving dialysis in Nova Scotia: a retrospective analysis.

BACKGROUND: The risk of death and complications after major trauma in patients with chronic kidney disease (CKD) is higher than in the general population, but whether this association holds true among Canadian trauma patients is unknown.
OBJECTIVES: To characterize patients with CKD/receiving dialysis within a regional major trauma cohort and compare their outcomes with patients without CKD.
METHODS: All major traumas requiring hospitalization between 2006 and 2017 were identified from a provincial trauma registry in Nova Scotia, Canada. Trauma patients with stage ≥3 CKD (estimated glomerular filtration rate <60 mL/min/1.73 m2) or receiving dialysis were identified by cross-referencing two regional databases for nephrology clinics and dialysis treatments. The primary outcome was in-hospital mortality; secondary outcomes included hospital/intensive care unit (ICU) length of stay (LOS) and ventilator-days. Cox regression was used to adjust for the effects of patient characteristics on in-hospital mortality.
RESULTS: In total, 6237 trauma patients were identified, of whom 4997 lived within the regional nephrology catchment area. CKD/dialysis trauma patients (n=101; 28 on dialysis) were older than patients without CKD (n=4896), with higher rates of hypertension, diabetes, and cardiovascular disease, and had increased risk of in-hospital mortality (31% vs 11%, p<0.001). No differences were observed in injury severity, ICU LOS, or ventilator-days. After adjustment for age, sex, and injury severity, the HR for in-hospital mortality was 1.90 (95% CI 1.33 to 2.70) for CKD/dialysis compared with patients without CKD.
CONCLUSION: Independent of injury severity, patients without CKD/dialysis have significantly increased risk of in-hospital mortality after major trauma. © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Background

Trauma patients with underlying chronic kidney disease (CKD) are at higher risk of complications and are more likely to die from these complications compared with patients with other serious medical comorbidities.1–3 These risks are even greater in patients with end-stage renal disease (ESRD) despite treatment with renal replacement therapies (RRTs) such as hemodialysis and peritoneal dialysis.1 2 Certain clinical and demographic aspects of patients with CKD have been associated with higher risk of experiencing trauma or suffering complications after traumatic injury. These include hemodynamic and laboratory variables,4–8 preceding specialized nephrology care,8 renal-specific medication use,6 frailty,9 10 RRT modality (peritoneal dialysis vs hemodialysis),5 11 and timing of dialysis treatments.4 8

The best overall index of kidney function is the glomerular filtration rate (GFR), and the National Kidney Foundation recommends using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation for estimated glomerular filtration rate (eGFR).12 Previous studies investigating characteristics of patients with CKD/receiving dialysis who experienced major trauma have largely used older methods to classify patients with renal disease;1–6 8–11 only one used the CKD-EPI equation and this study was limited to fall-related traumas.7 Identifying factors associated with adverse outcomes in all trauma patients with CKD and ESRD may lead to optimization of their care.

To date, major trauma outcomes have not been evaluated in a Canadian cohort of patients with CKD. We therefore sought to describe the characteristics of CKD and dialysis patients who experienced major trauma at a Canadian level 1 trauma center. We aimed to compare immediate post-trauma outcomes for patients with CKD/receiving dialysis versus those without.

Methods

Study design and data sources

We analyzed a cohort of all patients with stage 3-5D CKD,13 who were followed by the Nova Scotia Central Zone Renal Program and who experienced major trauma requiring admission to the Queen Elizabeth II Health Sciences Centre (QEII HSC) in Halifax, Nova Scotia, Canada between January 1, 2006 and December 31st, 2017. The Central Zone Renal Program manages kidney care for approximately 75% of the population of Nova Scotia (2016 census population 923 598).14 Nova Scotia has a provincial trauma service where all major trauma patients are referred for tertiary care to the QEII HSC, the only adult level 1 trauma center in the province. Trauma team leaders include both operation-based and emergency medicine-based specialists.

A waiver of consent was provided by the Nova Scotia Health Research Ethics Board, given this was a retrospective analysis of existing data sources,. The data used have previously been collected as part of the routine care of dialysis/trauma patients. No additional information or biological samples were required to be collected as a result of this study and all subsequent analysis and presentations were in aggregate. This study was performed in accordance with the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines for reporting observational studies.15 It was not appropriate or possible to involve patients or the public in the design, or conduct, or reporting, or dissemination plans of our research.

Three data sources were used to identify patients that were included in the study cohort. Each of these datasets was linked using unique patient identifiers (ie, health card number and date of birth).

Trauma patients were identified using the Nova Scotia Trauma Registry (NSTR). The NSTR is a provincial population-based registry under the Nova Scotia Department of Health and Wellness with data on all patients having an Injury Severity Score (ISS) ≥12 and an appropriate International Classification of Disease External Cause of Injury Code (ICD-10-CA).16 The registry also includes penetrating traumas with an ISS ≥9, all trauma team activations regardless of ISS (online supplemental digital content table 1), and traumas resulting in death pre-hospital or in the emergency department (ED). For the purposes of this study, we excluded any trauma patients who resided outside of the Nova Scotia Central Zone catchment area to avoid misclassification bias in coding for CKD/dialysis (ie, patients outside of this area would not have been captured in either of the two databases noted below).

All patients who were followed by the Nova Scotia Central Zone Renal Program and had dialysis initiated between January 1, 2003 and December 31, 2017 were identified using the MyNephrology database. We chose the earliest available date in MyNephrology which was an earlier date range than the NSTR. This ensured that prevalent dialysis patients who experienced trauma would have been included in this study. MyNephrology is a clinical database that contains information on incident in-center hemodialysis patients from dialysis units affiliated with the Nova Scotia Central Zone Renal Program and has been previously used in analyses of patients receiving dialysis from this zone.17 18 Data collected at the time of dialysis initiation includes information on patient demographics (age, sex), comorbidities and select laboratory values.

Patients assessed in the Nova Scotia Central Zone Renal Program outpatient nephrology clinic between January 1, 2003 and December 31, 2017 were identified from the hospital registration system and linked with records from the NSTR to ensure that all patients with CKD who sustained a major trauma during this time period were included. Chart review was performed on those patients identified from the hospital registration system and NSTR as having CKD to verify that only patients with stage 3 or higher CKD (eGFR <60 mL/min/1.73 m2 using the CKD-EPI equation)12 at least once in the 6 months prior to the date of hospital admission for trauma were included in the CKD cohort. Patients without dialysis without a measured serum creatinine within 6 months of the admission date for trauma were excluded.

Data collection

From the NSTR, we collected data on patient demographics (age, sex), cause of injury, injury type (blunt, penetrating, drowning, asphyxia, burns), injury severity (ISS, Glasgow Coma Scale score at the scene and on ED arrival, max Abbreviated Injury Scale-Head score), number of ventilator days, requirement for and number of blood product transfusions, length of stay (LOS) in the intensive care unit (ICU), in-hospital LOS, National Trauma Registry (NTR) complications,19 and in-hospital mortality. Data on in-hospital LOS or mortality occurring outside of a Nova Scotia Health Central Zone facility were not available; these patients are recorded as having transferred to another acute care facility. Data collected from MyNephrology and chart review included laboratory variables (sodium, potassium, calcium, phosphorus, albumin, and urea reduction ratio for dialysis patients at the closest measurement preceding the date of trauma), Charlson Comorbidity Index, and patient comorbidities. Patient name, health card number, and date of birth were used to link records from the NSTR with patients in MyNephrology and with their medical charts. Relevant clinical and demographic data for patients with CKD that were not available from the NSTR or MyNephrology databases were obtained from chart review. Assessment in the ED 30 days prior to the injury date was determined from chart review for patients with CKD and dialysis.

Outcomes

The primary outcome of this study was in-hospital mortality, defined as death occurring on arrival to the hospital or in any inpatient ward location prior to discharge. Secondary outcomes included in-hospital LOS, ICU LOS, ventilator-days, need for blood transfusion, and number of transfusions (inclusive of blood or other products). In addition, NTR-defined complications arising after trauma were categorized and collected.

Statistical analysis

Univariable statistics (proportions for categorical variables, mean±SD for continuous normally distributed variables and medians/Quartile 1 to Quartile 3 for non-normally distributed variables) were used to describe baseline characteristics of patients with CKD who experienced trauma. Statistical comparisons in available baseline characteristics between those with CKD/dialysis and without CKD were made using the Wilcoxon rank sum test (for non-normally distributed continuous variables) and χ² test for categorical variables. A similar approach was used for crude comparisons of outcomes between these two groups.

Unadjusted comparisons of in-hospital outcomes (including mortality, transfusion, ventilator and ICU days/1000 admission days after trauma) were reported using incidence rate ratios with 95% CIs. The adjusted association of CKD/dialysis status with in-hospital mortality was analyzed using a Cox proportional hazards regression model and reported using a HR with 95% CI. Proportionality was assessed using Schoenfeld’s global test. Only age, sex and injury severity (using ISS) were included in the primary model, as it was determined a priori that comorbidities were likely under-reported in the NSTR cohort. However, we did adjust for select comorbidities using available ICD-10-CA codes in a subsequent model. Anticipating a small number of patients with CKD/receiving dialysis with major trauma, we elected to treat the exposure of interest as a combined group. However, in a sensitivity analysis, we examined the unadjusted association with mortality compared with patients without non-CKD for CKD stage 3 to 5 and dialysis, separately. In keeping with the privacy policy of the Nova Scotia Department of Health and Wellness, any counts less than 5 are suppressed and are reported as n<5. All statistical analyses were performed using Stata (V.16, College Station, TX).

Patient and public involvement

No patient involved.

Results

Patient characteristics

A total of 6237 patients were assessed for major trauma at the QEII HSC between January 1, 2006 and December 31, 2017 (figure 1). Of these, 4997 patients had postal codes within the Nova Scotia Central Zone. Of these, 73 had stage 3 to 5D CKD, 28 were receiving dialysis, and 4896 were patients without non-CKD/dialysis.

Figure 1

Patient identification and classification into separate cohorts using the inclusion/exclusion criteria described in the text. Trauma records were identified from January 1, 2006 to December 31, 2017. CKD, chronic kidney disease, QEII HSC, Queen Elizabeth II Health Sciences Centre.

Patient characteristics are shown in table 1. The CKD/dialysis cohort was significantly older than the non-CKD cohort and had a greater proportion of female patients. Injury severity was similar in the CKD/dialysis and non-CKD groups. There was a significantly higher rate of blunt injury mechanisms in the CKD/dialysis cohort, with 67% of injuries in the CKD/dialysis group occurring as a result of a fall. We also observed a higher rate of serious head injuries in the CKD/dialysis group.

Table 1

Baseline characteristics of all patients with/without advanced CKD or dialysis

Variable	No CKD(n=4896)	CKD/dialysis(n=101)	P value
Age, mean±SD	51±22	71±13	<0.001
Female sex, n (%)	1342 (27)	41 (41)	0.005
ISS, median (Q1–Q3)	17 (13–25)	17 (16–25)	0.21
Blunt injury type, n (%)	4332 (88)	99 (98)	0.048
GCS on scene <8 (n=3937), n (%)	429 (11)	7 (10)	0.85
Max AIS Head score >2 (n=2684), n (%)	2025 (78)	66 (93)	0.001
Comorbidities,* n (%)
Diabetes	159 (3)	17 (17)	<0.001
Hypertension	267 (5)	20 (20)	<0.001
Congestive heart failure	39 (1)	7 (7)	<0.001
Coronary artery disease	109 (2)	10 (10)	<0.001
Peripheral vascular disease	27 (1)	n<5	0.003
Cerebrovascular disease	79 (2)	n<5	0.08
Chronic lung disease	70 (1)	n<5	0.18
Dementia	70 (1)	n<5	0.66

*Comorbidities were collected from the NSTR using available ICD-10-CA diagnostic codes.

AIS, Abbreviated Injury Score; CKD, chronic kidney disease; GCS, Glasgow Coma Scale; ISS, Injury Severity Score; NSTR, Nova Scotia Trauma Registry; Q1–Q3, Quartile 1–Quartile 3.

Additional baseline characteristics of the CKD/dialysis cohort including comorbidities and pretrauma laboratory values are shown in table 2. Of the 28 individuals receiving dialysis, the majority (86%) were receiving in-center hemodialysis. The CKD subcohort had a median preinjury eGFR of 33 mL/min/1.73 m2.

Table 2

Characteristics of patients with CKD/receiving dialysis who experienced major trauma

Variable	Major trauma patients(n=101)
Demographics
Age, mean±SD	71±13
Female sex, n (%)	41 (41)
Receiving dialysis, n (%)	28 (28)
Dialysis type, n (%)
None	73 (73)
In-center hemodialysis	24 (24)
Home hemodialysis	n<5
Peritoneal dialysis	n<5
Dialysis access (n=28), n (%)
Arteriovenous fistula	12 (43)
Hemodialysis catheter	14 (50)
Peritoneal dialysis catheter	n<5
Comorbidities, n (%)
Diabetes	38 (38)
Congestive heart failure	29 (29)
Coronary artery disease	35 (35)
Peripheral vascular disease	24 (24)
Cerebrovascular disease	24 (24)
Chronic lung disease	20 (20)
Malignancy	10 (10)
Connective tissue disease	6 (6)
Peptic ulcer disease	8 (8)
Dementia	11 (11)
Prior kidney transplant	n<5
Charlson Comorbidity Index score, median score (Q1–Q3)	6 (4–7)
Emergency department visit in 30 days preceding trauma, n (%)	16 (16)
Injury characteristics
Max AIS Head score >2 (n=71), n (%)	66 (93)
Max AIS Head score (n=71), median (Q1–Q3)	4 (4–5)
GCS score (n=73), median (Q1–Q3)	15 (13–15)
GCS score <8 (n=73), n (%)	7 (10)
ISS, median (Q1–-Q3)	17 (16–25)
Blunt injury type, n (%)	99 (98)
Injury mechanism, n (%)
Fall	67 (67)
Motor vehicle collision	18 (18)
All-terrain or recreational vehicle	n<5
Other*	12 (12)
Laboratory values, median (Q1–Q3)
eGFR (n=73)	33 (21–44)
Albumin (n=73)	35 (31–39)
Sodium (n=98)	139 (137–141)
Potassium (n=100)	4.7 [4.3–5.0)
Calcium (n=80)	2.25 (2.19–2.37)
Hemoglobin (n=98)	112 (100–128)
Urea reduction ratio (n=24)	69 (63–76)

*Assault, animal fall, or not otherwise specified.

AIS, Abbreviated Injury Scale; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; GCS, Glasgow Coma Scale; ISS, Injury Severity Score; Q1–Q3, Quartile 1–Quartile 3.

Primary outcome

In-hospital mortality was significantly higher in the CKD/dialysis group (31% vs 11%), corresponding to a crude mortality incident rate of 19 deaths per 1000 inpatient-days in the CKD/dialysis group compared with 7 deaths per 1000 inpatient-days in the non-CKD group (incidence rate ratio 2.60) (table 3). After adjusting for age, sex, and injury severity, patients with CKD/receiving dialysis had nearly double the risk of mortality compared with the non-CKD group (table 4). The association with mortality persisted after adjustment for ICD-10-CA comorbidities documented in the trauma database. Treating CKD and dialysis as separate exposures, there was a graded effect on mortality that persisted after multivariable adjustment (table 5).

Table 3

Crude in-hospital outcomes

Variable	No CKD(n=4896)	CKD/dialysis(n=101)	Incidence rate*	Unadjusted incidence rate ratio(95% CI) comparing CKD/dialysis to No CKD	P value
Any in-hospital complication	537 (11)	16 (16)	9/7	1.23 (0.70 to 2.02)	0.40
Need for red cell transfusions	406 (8)	n<5	1/6	0.20 (0.02 to 0.74)	0.004
Any transfusion	516 (11)	11 (10)	6/7	0.88 (0.44 to 1.59)	0.71
Days in hospital	5 (2–15)	7 (3–23)	–	–	0.052
Days in ICU	0 (0–3)	0 (0–5)	168/148	1.14 (0.98 to 1.31)	0.08
Ventilator days	0 (0–0)	0 (0–1)	75/75	1.00 (0.84 to 1.19)	0.96
In-hospital mortality	525 (11)	33 (33)	19/7	2.60 (1.77 to 3.70)	<0.001
Disposition on discharge					<0.001
Home	3184 (65)	48 (48)	–	–
Other acute care facility	461 (9)	12 (12)	–	–
Nursing home	93 (2)	n<5	–	–
Rehabilitation facility	475 (10)	n<5	–	–
Other/unknown	158 (3)	n<5	–	–

*CKD/dialysis vs no CKD/1000 inpatient-days.

CKD, chronic kidney disease; ICU, intensive care unit.

Table 4

Adjusted association between exposure (CKD/dialysis status) and in-hospital mortality after trauma

Model	HR	95% CI	P value
Model 1
CKD/dialysis (vs no CKD)	2.73	1.92 to 3.89	<0.001
Model 2
CKD/dialysis (vs no CKD)	1.90	1.33 to 2.70	<0.001
ISS (each 1-point increase)	1.06	1.05 to 1.07	<0.001
Age (every year increase)	1.03	1.03 to 1.04	<0.001
Men	1.04	0.87 to 1.25	0.67
Model 3
CKD/dialysis (vs no CKD)	1.93	1.35 to 2.75	<0.001
ISS (each 1-point increase)	1.06	1.05 to 1.07	<0.001
Age (every year increase)	1.03	1.02 to 1.03	<0.001
Men	1.02	0.85 to 1.23	0.79
Diabetes	0.74	0.50 to 1.09	0.13
Coronary artery disease	1.50	1.06 to 2.12	0.021
Cerebrovascular disease	1.32	0.86 to 2.02	0.20
Congestive heart failure	1.61	0.99 to 2.60	0.06
Peripheral vascular disease	1.30	0.67 to 2.53	0.44

CKD, chronic kidney disease; ISS, Injury Severity Score.

Table 5

Adjusted association between CKD or dialysis status (treated as separate categories) and in-hospital mortality after trauma

Model	HR	95% CI	P value
Unadjusted
No CKD (REFERENCE)	–	–	–
CKD	2.45	1.60 to 3.75	<0.001
Dialysis	3.57	1.96 to 6.48	<0.001
Adjusted*
No CKD (REFERENCE)	–	–	–
CKD	1.59	1.03 to 2.44	0.04
Dialysis	3.07	1.69 to 5.59	<0.001

*Adjusted for ISS, age and sex.

CKD, chronic kidney disease; ISS, Injury Severity Score.

Secondary outcomes

In unadjusted analysis, there was no significant difference between patients with CKD/dialysis and without non-CKD in terms of ICU LOS, ventilator-days, or need for any blood product transfusion (table 3). Compared with patients without non-CKD, there were fewer patients with CKD/receiving dialysis who required any red blood cell transfusion and fewer patients with CKD/receiving dialysis that returned home after admission for trauma. Occurrence of any in-hospital NTR complication was not significantly different between the CKD/dialysis and non-CKD groups and only a small proportion (1/101; 1% and 65/4891; 1%, respectively) experienced three or more complications. Pneumonia was the most common complication for patients with CKD/receiving dialysis, whereas urinary tract infections were observed most frequently in the non-CKD group.

Discussion

In this study, we found that patients with CKD and dialysis have significantly increased risk of mortality after trauma compared with patients without CKD, even after adjustment for age, sex, and injury severity. In keeping with previous findings, the majority of trauma patients were men, although interestingly there was a significantly higher proportion (though still a minority) of women in the CKD/dialysis group than in the non-CKD group. In some previous studies, women with CKD were more likely to suffer fall-related injuries than men,7 but men were more likely to fall than women when patients with ESRD were considered.4 6 Patients with CKD/receiving dialysis also experienced longer hospital LOS and were less likely to be discharged home after suffering a traumatic injury compared with patients without CKD. Unexpectedly, we did not find a higher rate of complications, greater requirement for ICU level of care, or higher blood product transfusion requirements in the CKD/dialysis group. The significantly lower requirement for any blood products among patients with CKD/receiving dialysis may be a reflection of the higher mortality in this group (ie, those patients who died did not require blood transfusions). Alternatively, it could be related to more fall-related or blunt injuries in the CKD/dialysis group, with lower blood product requirements expected. Whereas patients with CKD/receiving dialysis were more likely to be involved in injuries with a blunt mechanism, injury severity did not significantly differ between patients with CKD/receiving dialysis and patients without non-CKD. These findings suggest that the presence of CKD or ESRD is an important and independent risk factor for poor outcomes after trauma.

Similar to previous studies, we have shown that patients with renal disease have worse outcomes after trauma. Lorelli et al reported 2.45-fold increased risk of mortality in patients with ESRD compared with the general population after trauma despite similar severities of injury.1 Interestingly, Hollis et al observed 22.4-fold increased odds of death in patients with CKD despite lower overall injury severities (ie, ISS <16).20 In a large American cohort study, Bell et al reported 2.34-fold increased HR of failure to rescue (FTR or death subsequent to an adverse event) in patients receiving dialysis after trauma.2 More recently, an analysis of geriatric patients with fall-related trauma found that CKD increased 2.5-fold the likelihood of in-hospital mortality.21 Whereas we found very similar degrees of overall injury severity between patients with CKD/receiving dialysis and patients without CKD trauma, our finding of higher rates of head injury among the former group lends support to the idea that patients with CKD/receiving dialysis experience different types of trauma compared with patients without CKD. Indeed, nearly two-thirds of traumas in the CKD/dialysis group were due to falls, and this group was also significantly older with a higher comorbidity burden than the non-CKD group. Future research may be needed to analyze if patients with CKD/receiving dialysis patients who sustain certain types of major trauma (eg, traumatic brain injury) require specialized management strategies.

Our study further adds to the literature on trauma outcomes in patients with pre-existing renal disease by using the CKD-EPI equation to identify patients with CKD and describing the components of medical care provided post-trauma including ICU interventions, blood product transfusions, and hospital LOS. We describe dialysis treatments in trauma patients with ESRD in greater detail by examining dialysis vascular access and small-solute dialysis adequacy. These descriptive data thus add to the relatively limited literature on medical care provided to patients receiving dialysis prior to trauma. Other dialysis-related variables, such as time between hemodialysis sessions, which has been associated with a greater risk of cardiovascular events and mortality,22 23 and predialysis blood pressure,6 may be important to consider in future studies. The mechanism by which underlying renal disease impacts on trauma patient survival also remains poorly understood. It is possible that the presence of CKD leads to more difficult management of complications (eg, infections, electrolyte/acid-base disturbances, drug toxicity),24 with attendant higher mortality. In our experience with patients with CKD who experience major trauma and are seen at the QEII HSC, nephrology services are rapidly requested in the vast majority of cases, thus minimizing any delays to nephrology consultation for these patients.

The strengths of this study include the use of a rigorous patient linkage technique to ensure as many trauma patients with CKD as possible were included in our analysis and to avoid misclassification and subsequent bias. In addition, the inclusion of manual chart review allowed for a more accurate ability to capture patients with CKD using eGFR, as opposed to simple documentation in the chart or use of an arbitrary creatinine cut-off. In our study, the use of a lower eGFR threshold to define CKD reduced the probability of misclassification due to lack of capture of individuals with earlier stage CKD (in whom nephrology follow-up and regular bloodwork may not have occurred).

Our study also has some important limitations. Unfortunately, data on FTR were not captured in the NSTR, and so it is difficult to distinguish between death due to the original trauma and death due to subsequent complications. Our study was also limited by a lack of complete comorbidity data in the trauma registry as demonstrated by the differences in the proportion of individuals with select comorbid conditions using ICD-10 CA codes from the trauma database versus manual chart review/database review (not shown). Trauma patients with pre-existing CKD who were not previously seen by a nephrologist may not have been included as they would not have a record in MyNephrology; however, we minimized the likelihood of this by using a timeframe for inclusion in MyNephrology of 3 years prior to the first cohort entry in the NSTR. Relatively few patients with other modalities of RRT (eg, peritoneal dialysis and kidney transplant) were identified, which may reflect a lower incidence of trauma in patients treated with these modalities, as others have suggested.5 11 Finally, although we examined a large and recent trauma cohort, the generalizability of our findings is limited by the small number of patients with CKD/receiving dialysis who experienced trauma and the fact that this cohort was drawn from a single region in a Canadian province.

In conclusion, patients with CKD/receiving dialysis are at significantly increased risk of in-hospital mortality after major trauma, independent of injury severity. This risk is higher in patients on dialysis compared with patients with CKD not yet requiring dialysis. We did not find evidence for increased requirements for ICU-level interventions or an increased risk of complications after trauma in patients with CKD/receiving dialysis compared with patients without CKD. Modified trauma management strategies may be necessary to address the greater mortality risk observed in trauma patients with pre-existing renal disease.