Literature DB >> 33905609

Streptozotocin-Induced Diabetic Models in Mice and Rats.

Brian L Furman1.   

Abstract

Streptozotocin (STZ) is an antibiotic that causes pancreatic islet β-cell destruction and is widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM). Detailed in this article are protocols for producing STZ-induced insulin deficiency and hyperglycemia in mice and rats. Also described are protocols for creating animal models for type 2 diabetes using STZ. These animals are employed for assessing the pathological consequences of diabetes and for screening potential therapies for the treatment of this condition.
© 2021 The Authors. © 2021 The Authors. Current Protocols published by Wiley Periodicals LLC.

Entities:  

Keywords:  high-fat; hyperglycemia; insulin deficiency; insulin resistance; insulitis; mouse or rat; nicotinamide; streptozotocin; type 1 diabetes mellitus; type 2 diabetes mellitus

Mesh：

Substances：

Year:  2021        PMID： 33905609     DOI： 10.1002/cpz1.78

Source DB:  PubMed          Journal:  Curr Protoc        ISSN： 2594-1321


  27 in total

Review 1.  Mouse models of type 1 diabetes and their use in skeletal research.

Authors:  Evangelia Kalaitzoglou; John L Fowlkes; Kathryn M Thrailkill
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Authors:  Andrew D Biancolin; Hyerin Jeong; Kimberly W Y Mak; Zixuan Yuan; Patricia L Brubaker
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Authors:  Kimberly J Jasmer; Kevin Muñoz Forti; Lucas T Woods; Seunghee Cha; Gary A Weisman
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Review 4.  Animal Models to Study Cardiac Arrhythmias.

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Review 5.  Guidelines on models of diabetic heart disease.

Authors:  Lisa C Heather; Anne D Hafstad; Ganesh V Halade; Romain Harmancey; Kimberley M Mellor; Paras K Mishra; Erin E Mulvihill; Miranda Nabben; Michinari Nakamura; Oliver J Rider; Matthieu Ruiz; Adam R Wende; John R Ussher
Journal:  Am J Physiol Heart Circ Physiol       Date:  2022-06-03       Impact factor: 5.125

6.  Brain activities of streptozotocin-induced diabetic Wistar rats treated with gliclazide: Behavioural, biochemical and histomorphology studies.

Authors:  Moses B Ekong; Francis N Odinukaeze; Amaobi C Nwonu; Christopher C Mbadugha; Agnes A Nwakanma
Journal:  IBRO Neurosci Rep       Date:  2022-04-14

7.  Glabridin, a bioactive component of licorice, ameliorates diabetic nephropathy by regulating ferroptosis and the VEGF/Akt/ERK pathways.

Authors:  Hongtao Tan; Junxian Chen; Yicong Li; Yingshan Li; Yunchang Zhong; Guangzhao Li; Lingling Liu; Yiqun Li
Journal:  Mol Med       Date:  2022-05-20       Impact factor: 6.376

Review 8.  The Role of the NLRP3 Inflammasome in Mediating Glomerular and Tubular Injury in Diabetic Nephropathy.

Authors:  B M Williams; C L Cliff; K Lee; P E Squires; C E Hills
Journal:  Front Physiol       Date:  2022-06-09       Impact factor: 4.755

9.  Analysis of CD4 and CD8 expression in multidrug-resistant tuberculosis infection with diabetes mellitus: An experimental study in mice.

Authors:  Heidy Agustin; Muhammad Nasrum Massi; Irawati Djaharuddin; Agus Dwi Susanto; Andi Asadul Islam; Mochammad Hatta; Agussalim Bukhari; Nur Ahmad Tabri; Arif Santoso; Ilhamjaya Patellongi
Journal:  Ann Med Surg (Lond)       Date:  2021-07-27

Review 10.  Emerging Roles of Myeloid-Derived Suppressor Cells in Diabetes.

Authors:  Shiqi Wang; Qian Tan; Yayi Hou; Huan Dou
Journal:  Front Pharmacol       Date:  2021-12-16       Impact factor: 5.810
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