Jing-Lin Yuan1, Rui-Xue Zhao2, Ya-Jun Ma2, Xiao-Dong Li2, Xiao-Mei Zhou1, Xiao-Feng Wang3, Xiao-Yan Jiang4, Shu-Juan Li2. 1. Department of Neurology, Beijing Daxing District People's Hospital, Beijing, China. 2. Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China. 3. Ministry of Education Key Laboratory of Contemporary Anthropology, Human Phenome Institute, Fudan University, Shanghai, China. 4. Department of Pathology and Pathophysiology, Tongji University School of Medicine, Shanghai, China.
Abstract
BACKGROUND: Motoric cognitive risk syndrome (MCR) is characterized by slow walking speed and subjective memory complaints (SMCs). This study investigated the prevalence and potential risk factors of MCR and its association with falls in Chinese community-dwelling older adults. METHODS: The analysis was based on data from the Rugao Longevity and Aging Study (RuLAS). MCR was defined as presence of both SMC and slow walking speed in participants free of major neurocognitive disorders. SMCs were determined according to a positive answer to the question "Do you feel you have more problems with memory than most?" in the 15-item Geriatric Depression Scale. Slow walking speed was defined as ≤1 standard deviation below the mean values for patients' age and sex. Data on falls were derived from a standardized questionnaire. RESULTS: The prevalence of SMC, slow walking speed, and MCR in the RuLAS cohort (N=1592) was 51.9%, 15.6%, and 8.3%, respectively. After adjusting for other covariates, an occupation of farming (OR=2.358; 95% CI: 1.007-5.521, P=0.048), history of cerebrovascular disease (OR=2.215; 95% CI: 1.032-4.752, P=0.041), and hospitalization (OR=2.008; 95% CI: 1.120-3.602, P=0.019) were risk factors for MCR. Binary logistic regression analysis indicated that the risk of falls was increased by MCR (OR=1.547; 95% CI: 1.009-2.371), SMC (OR=1.308; 95% CI: 1.003-1.707), and slow walking speed (OR=1.442; 95% CI: 1.030-2.017). CONCLUSIONS: Early identification of potential risk factors of MCR can prevent the occurrence of adverse health events such as falls in the elderly. This article is protected by copyright. All rights reserved.
BACKGROUND:Motoric cognitive risk syndrome (MCR) is characterized by slow walking speed and subjective memory complaints (SMCs). This study investigated the prevalence and potential risk factors of MCR and its association with falls in Chinese community-dwelling older adults. METHODS: The analysis was based on data from the Rugao Longevity and Aging Study (RuLAS). MCR was defined as presence of both SMC and slow walking speed in participants free of major neurocognitive disorders. SMCs were determined according to a positive answer to the question "Do you feel you have more problems with memory than most?" in the 15-item Geriatric Depression Scale. Slow walking speed was defined as ≤1 standard deviation below the mean values for patients' age and sex. Data on falls were derived from a standardized questionnaire. RESULTS: The prevalence of SMC, slow walking speed, and MCR in the RuLAS cohort (N=1592) was 51.9%, 15.6%, and 8.3%, respectively. After adjusting for other covariates, an occupation of farming (OR=2.358; 95% CI: 1.007-5.521, P=0.048), history of cerebrovascular disease (OR=2.215; 95% CI: 1.032-4.752, P=0.041), and hospitalization (OR=2.008; 95% CI: 1.120-3.602, P=0.019) were risk factors for MCR. Binary logistic regression analysis indicated that the risk of falls was increased by MCR (OR=1.547; 95% CI: 1.009-2.371), SMC (OR=1.308; 95% CI: 1.003-1.707), and slow walking speed (OR=1.442; 95% CI: 1.030-2.017). CONCLUSIONS: Early identification of potential risk factors of MCR can prevent the occurrence of adverse health events such as falls in the elderly. This article is protected by copyright. All rights reserved.