Kaitlyn Roche1, Catherine Racowsky2, Joyce Harper3. 1. University College London EGA Institute for Women's Health, London, UK. 2. Hospital Foch, Suresnes, France and Brigham and Women's Hospital, MA, Boston, USA. 3. University College London EGA Institute for Women's Health, London, UK. joyce.harper@ucl.ac.uk.
Abstract
PURPOSE: To evaluate the use of preimplantation genetic testing (PGT) and live birth rates (LBR) in the USA from 2014 to 2017 and to understand how PGT is being used at a clinic and state level. METHODS: This study accessed SART data for 2014 to 2017 to determine LBR and the CDC for years 2016 and 2017 to identify PGT usage. Primary cycles included only the first embryo transfer within 1 year of an oocyte retrieval; subsequent cycles included transfers occurring after the first transfer or beyond 1 year of oocyte retrieval. RESULTS: In the SART data, the number of primary PGT cycles showed a significant monotonic annual increase from 18,805 in 2014 to 54,442 in 2017 (P = 0.042) and subsequent PGT cycles in these years increased from 2946 to 14,361 (P = 0.01). There was a significant difference in primary PGT cycle use by age, where younger women had a greater percentage of PGT treatment cycles than older women. In both PGT and non-PGT cycles, the LBR per oocyte retrieval decreased significantly from 2014 to 2017 (P<0001) and younger women had a significantly higher LBR per oocyte retrieval compared to older women (P < 0.001). The CDC data revealed that in 2016, just 53 (11.4%) clinics used PGT for more than 50% of their cycles, which increased to 99 (21.4%) clinics in 2017 (P< 0.001). CONCLUSIONS: A growing number of US clinics are offering PGT to their patients. These findings support re-evaluation of the application for PGT.
PURPOSE: To evaluate the use of preimplantation genetic testing (PGT) and live birth rates (LBR) in the USA from 2014 to 2017 and to understand how PGT is being used at a clinic and state level. METHODS: This study accessed SART data for 2014 to 2017 to determine LBR and the CDC for years 2016 and 2017 to identify PGT usage. Primary cycles included only the first embryo transfer within 1 year of an oocyte retrieval; subsequent cycles included transfers occurring after the first transfer or beyond 1 year of oocyte retrieval. RESULTS: In the SART data, the number of primary PGT cycles showed a significant monotonic annual increase from 18,805 in 2014 to 54,442 in 2017 (P = 0.042) and subsequent PGT cycles in these years increased from 2946 to 14,361 (P = 0.01). There was a significant difference in primary PGT cycle use by age, where younger women had a greater percentage of PGT treatment cycles than older women. In both PGT and non-PGT cycles, the LBR per oocyte retrieval decreased significantly from 2014 to 2017 (P<0001) and younger women had a significantly higher LBR per oocyte retrieval compared to older women (P < 0.001). The CDC data revealed that in 2016, just 53 (11.4%) clinics used PGT for more than 50% of their cycles, which increased to 99 (21.4%) clinics in 2017 (P< 0.001). CONCLUSIONS: A growing number of US clinics are offering PGT to their patients. These findings support re-evaluation of the application for PGT.
Authors: Santiago Munné; Brian Kaplan; John L Frattarelli; Tim Child; Gary Nakhuda; F Nicholas Shamma; Kaylen Silverberg; Tasha Kalista; Alan H Handyside; Mandy Katz-Jaffe; Dagan Wells; Tony Gordon; Sharyn Stock-Myer; Susan Willman Journal: Fertil Steril Date: 2019-09-21 Impact factor: 7.329
Authors: F Zegers-Hochschild; G D Adamson; J de Mouzon; O Ishihara; R Mansour; K Nygren; E Sullivan; S Vanderpoel Journal: Fertil Steril Date: 2009-10-14 Impact factor: 7.329
Authors: S Pereira; S Carmi; G Altarescu; J Austin; D Barlevy; A Hershlag; E Juengst; K Kostick-Quenet; E Kovanci; R B Lathi; M Mukherjee; I Van den Veyver; O Zuk; G Lázaro-Muñoz; T Lencz Journal: Hum Reprod Date: 2022-06-30 Impact factor: 6.353
Authors: Benjamin J Peipert; Melissa N Montoya; Bronwyn S Bedrick; David B Seifer; Tarun Jain Journal: Reprod Biol Endocrinol Date: 2022-08-04 Impact factor: 4.982