Significance and innovation: cornerstones of a successful grant application.

The Significance and Innovation sections of a grant application are the cornerstones to a successful application. These sections emphasize the importance of the problem being studied, highlight what is novel about the proposal, and are an opportunity to get the reviewers excited about the application. To the novice grant writer, it may be difficult to know what "Significance" and "Innovation" are meant to describe. In this article we define the role of the Significance and Innovation sections and provide suggestions on what to include in each section and potential pitfalls to avoid.