Torsten Dahlén1,2, Mark Clements3, Jingcheng Zhao2, Martin L Olsson4, Gustaf Edgren2,5. 1. Hematology Department, Karolinska University Hospital, Stockholm, Sweden. 2. Department of Medicine Solna, Clinical Epidemiology Division, Karolinska Institutet, Stockholm, Sweden. 3. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. 4. Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University & Department of Clinical Immunology and Transfusion Medicine, Office of Medical Services, Region Skåne, Lund, Sweden. 5. Cardiology Department, Södersjukhuset, Stockholm, Sweden.
Abstract
Background: There are multiple known associations between the ABO and RhD blood groups and disease. No systematic population-based studies elucidating associations between a large number of disease categories and blood group have been conducted. Methods: Using SCANDAT3-S, a comprehensive nationwide blood donation-transfusion database, we modeled outcomes for 1217 disease categories including 70 million person-years of follow-up, accruing from 5.1 million individuals. Results: We discovered 49 and 1 associations between a disease and ABO and RhD blood groups, respectively, after adjustment for multiple testing. We identified new associations such as a decreased risk of kidney stones and blood group B as compared to blood group O. We also expanded previous knowledge on other associations such as pregnancy-induced hypertension and blood groups A and AB as compared to blood group O and RhD positive as compared to negative. Conclusions: Our findings generate strong further support for previously known associations, but also indicate new interesting relations. Funding: Swedish Research Council.
Background: There are multiple known associations between the ABO and RhD blood groups and disease. No systematic population-based studies elucidating associations between a large number of disease categories and blood group have been conducted. Methods: Using SCANDAT3-S, a comprehensive nationwide blood donation-transfusion database, we modeled outcomes for 1217 disease categories including 70 million person-years of follow-up, accruing from 5.1 million individuals. Results: We discovered 49 and 1 associations between a disease and ABO and RhD blood groups, respectively, after adjustment for multiple testing. We identified new associations such as a decreased risk of kidney stones and blood group B as compared to blood group O. We also expanded previous knowledge on other associations such as pregnancy-induced hypertension and blood groups A and AB as compared to blood group O and RhD positive as compared to negative. Conclusions: Our findings generate strong further support for previously known associations, but also indicate new interesting relations. Funding: Swedish Research Council.
Authors: Roxana Merino Martinez; Heimo Müller; Stefan Negru; Alex Ormenisan; Laila Sara Arroyo Mühr; Xinyue Zhang; Frederik Trier Møller; Mark S Clements; Zisis Kozlakidis; Ville N Pimenoff; Bartlomiej Wilkowski; Martin Boeckhout; Hanna Öhman; Steven Chong; Andreas Holzinger; Matti Lehtinen; Evert-Ben van Veen; Piotr Bała; Martin Widschwendter; Jim Dowling; Juha Törnroos; Michael P Snyder; Joakim Dillner Journal: Environ Epidemiol Date: 2021-12-03
Authors: Thomas Kander; Martin F Bjurström; Attila Frigyesi; Magnus Jöud; Caroline U Nilsson Journal: BMC Anesthesiol Date: 2022-04-02 Impact factor: 2.217