Mickael Aubignat1, Melissa Tir2,3, Pierre Krystkowiak2, Daniela Andriuta2,3. 1. Department of Neurology and Center of Expertise in Parkinson's disease, University Hospital of Amiens, CHU Amiens-Picardie, 80 054 Cedex 1, Amiens, France. aubignat.mickael@chu-amiens.fr. 2. Department of Neurology and Center of Expertise in Parkinson's disease, University Hospital of Amiens, CHU Amiens-Picardie, 80 054 Cedex 1, Amiens, France. 3. Laboratory of Functional Neurosciences (EA 4559), University Hospital of Amiens, Amiens, France.
Abstract
BACKGROUND: Episodic headache with spontaneous hypothermia constitute an uncommon association and is not well recognized in the International Classification of Headache Disorders (ICHD-3). Spontaneous periodic hypothermia, also called Shapiro's syndrome, is a rare disease characterized by hypothermia attacks associated or not with hyperhidrosis without any triggering factor. CASE PRESENTATION: We report a rare case of Shapiro's syndrome variantrevealed by episodes of headache with spontaneous hypothermia witheffectiveness of clonidine therapy in a 76-year-old Parkinson's disease woman. CONCLUSIONS: In the literature, apart from Shapiro's syndrome, headache withhypothermia seem to occur very rarely. In our case,these symptoms may be considered as a very rare non-motor fluctuation ofParkinson's disease.
BACKGROUND:Episodic headache with spontaneous hypothermia constitute an uncommon association and is not well recognized in the International Classification of Headache Disorders (ICHD-3). Spontaneous periodic hypothermia, also called Shapiro's syndrome, is a rare disease characterized by hypothermia attacks associated or not with hyperhidrosis without any triggering factor. CASE PRESENTATION: We report a rare case of Shapiro's syndrome variantrevealed by episodes of headache with spontaneous hypothermia witheffectiveness of clonidine therapy in a 76-year-old Parkinson's diseasewoman. CONCLUSIONS: In the literature, apart from Shapiro's syndrome, headache withhypothermia seem to occur very rarely. In our case,these symptoms may be considered as a very rare non-motor fluctuation ofParkinson's disease.