Angeline S Andrew1, Erik P Pioro2, Meifang Li3, Xun Shi3, Jiang Gui4, Elijah W Stommel1, Tanya H Butt1, Daniel Peipert1, Patricia Henegan1, Maeve Tischbein1, Pamela Cazzolli5, John Novak6, Adam Quick7, K Doug Pugar8, Komal Sawlani9, Bashar Katirji9, Todd A Hayes10, D Kevin Horton11, Paul Mehta11, Walter G Bradley12. 1. Department of Neurology, Geisel School of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA. 2. Section of ALS and Related Disorders, Cleveland Clinic, Cleveland, Ohio, USA. 3. Department of Geography, Dartmouth College, Hanover, New Hampshire, USA. 4. Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA. 5. ALS Care Project, Canton, Ohio, USA. 6. Ohio Health Physician Group, Westerville, Ohio, USA. 7. Department of Neurology, Ohio State University Wexner Medical Center, Columbus, Ohio, USA. 8. Dayton Center for Neurological Disorders, Dayton, Ohio, USA. 9. Department of Neurology, University Hospital Cleveland Medical Center, Cleveland, Ohio, USA. 10. Riverhills Neuroscience, Cincinnati, Ohio, USA. 11. Centers for Disease Control and Prevention (CDC), Agency for Toxic Substances and Disease Registry (ATSDR), Atlanta, Georgia, USA. 12. Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Abstract
INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a fatal, neuromuscular disease with no cure. ALS incidence rates have not been assessed specifically in Ohio, yet the state contains both metropolitan and rural areas with a variety of environmental factors that could contribute to disease etiology. We report the incidence of ALS in Ohio residents diagnosed from October 2016 through September 2018. METHODS: We engaged practitioners from 9 Ohio sites to identify newly diagnosed ALS patients and to complete case report forms with demographic and clinical information. ALS was diagnosed according to the Awaji criteria and classified as either definite, probable, or possible. We developed a method to estimate missing cases using a Poisson regression model to impute cases in counties with evidence of undercounting. RESULTS: We identified 333 newly diagnosed ALS patients residing in Ohio during the 2-year index period and found incidence rates varied in the 88 state counties. After incorporating the estimated 27% of missing cases, the corrected crude annual incidence was 1.96/100,000 person-years, and the age- and gender-standardized incidence was 1.71/100,000 person-years (standardized to the 2010 US census). DISCUSSION/ CONCLUSION: The estimated Ohio incidence of ALS is overall similar to that reported in other states in the USA. This study reveals a geospatial variation in incidence within the state, and areas with higher rates warrant future investigation. The Author(s). Published by S. Karger AG, Basel.
INTRODUCTION:Amyotrophic lateral sclerosis (ALS) is a fatal, neuromuscular disease with no cure. ALS incidence rates have not been assessed specifically in Ohio, yet the state contains both metropolitan and rural areas with a variety of environmental factors that could contribute to disease etiology. We report the incidence of ALS in Ohio residents diagnosed from October 2016 through September 2018. METHODS: We engaged practitioners from 9 Ohio sites to identify newly diagnosed ALSpatients and to complete case report forms with demographic and clinical information. ALS was diagnosed according to the Awaji criteria and classified as either definite, probable, or possible. We developed a method to estimate missing cases using a Poisson regression model to impute cases in counties with evidence of undercounting. RESULTS: We identified 333 newly diagnosed ALSpatients residing in Ohio during the 2-year index period and found incidence rates varied in the 88 state counties. After incorporating the estimated 27% of missing cases, the corrected crude annual incidence was 1.96/100,000 person-years, and the age- and gender-standardized incidence was 1.71/100,000 person-years (standardized to the 2010 US census). DISCUSSION/ CONCLUSION: The estimated Ohio incidence of ALS is overall similar to that reported in other states in the USA. This study reveals a geospatial variation in incidence within the state, and areas with higher rates warrant future investigation. The Author(s). Published by S. Karger AG, Basel.
Entities:
Keywords:
Amyotrophic lateral sclerosis; Epidemiology; Hot spots; Incidence; Ohio
Authors: Tracie A Caller; Nicholas C Field; Jonathan W Chipman; Xun Shi; Brent T Harris; Elijah W Stommel Journal: Amyotroph Lateral Scler Date: 2012-01