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Literature DB >> 3390157

Biochemical measurements in Alzheimer's disease reveal a necessity for improved neuroimaging techniques to study metabolism.

Abstract

A series of Alzheimer's disease and control brains were dissected to determine the extent of atrophy (based on total protein content) and loss of choline acetyltransferase activity in the cerebral cortex from the entire surface of the diseased brains. The distribution of intensity of pathology so determined is strikingly similar to the degree of hypometabolism as shown by positron emission tomography. It is argued that the hypometabolism can be explained (at least in part) by focal areas of atrophy.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1988 PMID： 3390157 PMCID： PMC1148998 DOI： 10.1042/bj2510305

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

16 in total

1. FABRY'S DISEASE: CLASSIFICATION AS A SPHINGOLIPIDOSIS AND PARTIAL CHARACTERIZATION OF A NOVEL GLYCOLIPID.

Authors: C C SWEELEY; B KLIONSKY
Journal: J Biol Chem Date: 1963-09 Impact factor: 5.157

2. Selective vulnerability of neurones in organic dementia.

Authors: J A Spillane; P White; W J Goodhardt; R H Flack; D M Bowen; A N Davison
Journal: Nature Date: 1977-04-07 Impact factor: 49.962

3. Accelerated ageing or selective neuronal loss as an important cause of dementia?

Authors: D M Bowen; P White; J A Spillane; M J Goodhardt; G Curzon; P Iwangoff; W Meier-Ruge; A N Davison
Journal: Lancet Date: 1979-01-06 Impact factor: 79.321

4. Regional cerebral oxygen supply and utilization in dementia. A clinical and physiological study with oxygen-15 and positron tomography.

Authors: R S Frackowiak; C Pozzilli; N J Legg; G H Du Boulay; J Marshall; G L Lenzi; T Jones
Journal: Brain Date: 1981-12 Impact factor: 13.501

5. [14C]acetylcholine synthesis and [14C]carbon dioxide production from [U-14C]glucose by tissue prisms from human neocortex.

Authors: N R Sims; D M Bowen; A N Davison
Journal: Biochem J Date: 1981-06-15 Impact factor: 3.857

6. Globoid cell leucodystrophy (Krabbe's disease): deficiency of galactocerebroside beta-galactosidase.

Authors: K Suzuki; Y Suzuki
Journal: Proc Natl Acad Sci U S A Date: 1970-06 Impact factor: 11.205

7. Comparison of PET, MRI, and CT with pathology in a proven case of Alzheimer's disease.

Authors: P L McGeer; H Kamo; R Harrop; E G McGeer; W R Martin; B D Pate; D K Li
Journal: Neurology Date: 1986-12 Impact factor: 9.910

8. Intercorrelations of regional cerebral glucose metabolic rates in Alzheimer's disease.

Authors: B Horwitz; C L Grady; N L Schlageter; R Duara; S I Rapoport
Journal: Brain Res Date: 1987-03-31 Impact factor: 3.252

9. A quantitative study of cerebral atrophy in old age and senile dementia.

Authors: B M Hubbard; J M Anderson
Journal: J Neurol Sci Date: 1981-04 Impact factor: 3.181

10. Alzheimer's disease: low cerebral somatostatin levels correlate with impaired cognitive function and cortical metabolism.

Authors: C A Tamminga; N L Foster; P Fedio; E D Bird; T N Chase
Journal: Neurology Date: 1987-01 Impact factor: 9.910

6 in total

1. Association of atrophy of the medial temporal lobe with reduced blood flow in the posterior parietotemporal cortex in patients with a clinical and pathological diagnosis of Alzheimer's disease.

Authors: K A Jobst; A D Smith; C S Barker; A Wear; E M King; A Smith; P A Anslow; A J Molyneux; B J Shepstone; N Soper
Journal: J Neurol Neurosurg Psychiatry Date: 1992-03 Impact factor: 10.154