Federico Corvi1,2,3, Giulia Corradetti1,2, Liran Tiosano1,4, John Adam McLaughlin5, Thomas K Lee5, Srinivas R Sadda6,7. 1. Doheny Eye Institute, University of California at Los Angeles, Los Angeles, CA, USA. 2. Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. 3. Eye Clinic, Department of Biomedical and Clinical Science "Luigi Sacco", Sacco Hospital, University of Milan, Milan, Italy. 4. Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. 5. Department of Ophthalmology, Retina Centre of Ottawa, University of Ottawa, Ottawa, ON, Canada. 6. Doheny Eye Institute, University of California at Los Angeles, Los Angeles, CA, USA. ssadda@doheny.org. 7. Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. ssadda@doheny.org.
Abstract
PURPOSE: To evaluate the relationship between choriocapillaris (CC), flow deficits (FD), and structural optical coherence tomography (OCT) biomarkers, and the progression of intermediate age-related macular degeneration (iAMD) to complete retinal pigment epithelial and outer retinal atrophy (cRORA) or macular neovascularization (MNV). METHODS: Consecutive patients with iAMD were sequentially reviewed to define three equal sized groups: progressed to MNV, progressed to cRORA, or remained stable over 12 months of follow-up. Odds ratios for progression to cRORA and MNV were estimated by logistic regression for intraretinal hyperreflective foci (IHRF), hyporeflective drusen cores (hDC), subretinal drusenoid deposits (SDDs), high central drusen volume, fellow eye with late AMD, and peripheral and central CC FD. RESULTS: Thirty iAMD eyes from 30 patients were enrolled into each group. The CC FD was greater in the peripheral sectors of the macula of eyes which progressed to cRORA compared to the other two groups (P < 0.0001). The central CC FD was also significantly impaired in eyes that progressed to cRORA or MNV compared to eyes that did not progress (P = 0.001 and P = 0.02, respectively). CC FD in the peripheral macula was significantly and independently associated with the development of cRORA, while CC FD in the center was significantly and independently associated with the development of MNV. CONCLUSIONS: While the CC is diffusely impaired throughout the macula in iAMD eyes that progress to cRORA, it is relatively spared in the more peripheral macula among eyes which progress to MNV. These differential findings may have implications for the pathophysiology of the different late-stage manifestations of AMD.
PURPOSE: To evaluate the relationship between choriocapillaris (CC), flow deficits (FD), and structural optical coherence tomography (OCT) biomarkers, and the progression of intermediate age-related macular degeneration (iAMD) to complete retinal pigment epithelial and outer retinal atrophy (cRORA) or macular neovascularization (MNV). METHODS: Consecutive patients with iAMD were sequentially reviewed to define three equal sized groups: progressed to MNV, progressed to cRORA, or remained stable over 12 months of follow-up. Odds ratios for progression to cRORA and MNV were estimated by logistic regression for intraretinal hyperreflective foci (IHRF), hyporeflective drusen cores (hDC), subretinal drusenoid deposits (SDDs), high central drusen volume, fellow eye with late AMD, and peripheral and central CC FD. RESULTS: Thirty iAMD eyes from 30 patients were enrolled into each group. The CC FD was greater in the peripheral sectors of the macula of eyes which progressed to cRORA compared to the other two groups (P < 0.0001). The central CC FD was also significantly impaired in eyes that progressed to cRORA or MNV compared to eyes that did not progress (P = 0.001 and P = 0.02, respectively). CC FD in the peripheral macula was significantly and independently associated with the development of cRORA, while CC FD in the center was significantly and independently associated with the development of MNV. CONCLUSIONS: While the CC is diffusely impaired throughout the macula in iAMD eyes that progress to cRORA, it is relatively spared in the more peripheral macula among eyes which progress to MNV. These differential findings may have implications for the pathophysiology of the different late-stage manifestations of AMD.
Authors: Giovanni Gregori; Fenghua Wang; Philip J Rosenfeld; Zohar Yehoshua; Ninel Z Gregori; Brandon J Lujan; Carmen A Puliafito; William J Feuer Journal: Ophthalmology Date: 2011-03-09 Impact factor: 12.079
Authors: Khashayar Nattagh; Hao Zhou; Nicholas Rinella; Qinqin Zhang; Yining Dai; Katharina G Foote; Cathrine Keiner; Michael Deiner; Jacque L Duncan; Travis C Porco; Ruikang K Wang; Daniel M Schwartz Journal: Transl Vis Sci Technol Date: 2020-06-03 Impact factor: 3.283