| Literature DB >> 3390025 |
P J Whitehouse1, A M Martino, K A Marcus, R M Zweig, H S Singer, D L Price, K J Kellar.
Abstract
Alzheimer's disease, Parkinson's disease, and progressive supranuclear palsy are all characterized by loss of neurons in the basal forebrain cholinergic system and by associated reductions in cortical presynaptic cholinergic markers, such as choline acetyltransferase. In this report, we identify that a major cortical receptor alteration in these disorders is a reduction in nicotinic receptors measured using both tritiated acetylcholine and levorotatory tritiated nicotine binding.Entities:
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Year: 1988 PMID： 3390025 DOI： 10.1001/archneur.1988.00520310028012
Source DB: PubMed Journal: Arch Neurol ISSN： 0003-9942