Ilaria Bortone1, Chiara Griseta1, Petronilla Battista2, Fabio Castellana, Luisa Lampignano1, Roberta Zupo1, Giancarlo Sborgia3, Madia Lozupone4, Biagio Moretti4, Gianluigi Giannelli5, Rodolfo Sardone1, Francesco Panza1. 1. Unit of Research Methodology and Data Sciences for Population Health, "Salus in Apulia Study", National Institute of Gastroenterology "Saverio de Bellis", Research Hospital, Castellana Grotte, Bari, Italy. 2. Global Brain Health Institute, University of California, San Francisco, USA. 3. Eye Clinic, Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari, Bari, Italy. 4. Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari "Aldo Moro", Bari, Italy. 5. National Institute of Gastroenterology "Saverio de Bellis", Research Hospital, Castellana Grotte, Bari, Italy.
Abstract
BACKGROUND: In older age, physical and cognitive declines have been shown to occur simultaneously or consequent to one another and several operational definitions have been proposed to consider the co-presence of both. Among these constructs, the "Motoric Cognitive Risk" Syndrome (MCR) has been proposed as the co-existence of slow gait plus subjective cognitive complaints. Considering the increasing interest in MCR and its potential role as both biomarker and therapeutic target, we estimated its prevalence in a large cohort of non-demented older subjects, and we examined the associations between physical status, global cognitive dysfunction, and impairment in various cognitive domains in MCR. METHODS: A population-based sample of 1,041 older subjects of Southern Italy (mean age:75.15 years) has been enrolled. We defined MCR using slowness and a single question for subjective cognitive complaints. We also administered a comprehensive neuropsychological test battery together with tests assessing physical function. RESULTS: The prevalence of MCR was 9.9%, 95% confidence interval: 8.2%-11.9%. MCR was associated with decreased processing speed and executive function after adjusting for all relevant confounders. However, we found no significant association of MCR with decreased global cognition and immediate/delayed free recall of verbal memory. MCR was also associated with increased exhaustion, low muscle strength, and low physical activity, and increased levels of C-reactive protein and interleukin-6. CONCLUSIONS: The present findings on MCR prevalence and associated cognitive and physical domains and inflammatory biomarkers may help to uncover altered pathways and therapeutic targets for intervention during the long preclinical phase of neurodegenerative dementia. This article is protected by copyright. All rights reserved.
BACKGROUND: In older age, physical and cognitive declines have been shown to occur simultaneously or consequent to one another and several operational definitions have been proposed to consider the co-presence of both. Among these constructs, the "Motoric Cognitive Risk" Syndrome (MCR) has been proposed as the co-existence of slow gait plus subjective cognitive complaints. Considering the increasing interest in MCR and its potential role as both biomarker and therapeutic target, we estimated its prevalence in a large cohort of non-demented older subjects, and we examined the associations between physical status, global cognitive dysfunction, and impairment in various cognitive domains in MCR. METHODS: A population-based sample of 1,041 older subjects of Southern Italy (mean age:75.15 years) has been enrolled. We defined MCR using slowness and a single question for subjective cognitive complaints. We also administered a comprehensive neuropsychological test battery together with tests assessing physical function. RESULTS: The prevalence of MCR was 9.9%, 95% confidence interval: 8.2%-11.9%. MCR was associated with decreased processing speed and executive function after adjusting for all relevant confounders. However, we found no significant association of MCR with decreased global cognition and immediate/delayed free recall of verbal memory. MCR was also associated with increased exhaustion, low muscle strength, and low physical activity, and increased levels of C-reactive protein and interleukin-6. CONCLUSIONS: The present findings on MCR prevalence and associated cognitive and physical domains and inflammatory biomarkers may help to uncover altered pathways and therapeutic targets for intervention during the long preclinical phase of neurodegenerative dementia. This article is protected by copyright. All rights reserved.
Entities:
Keywords:
biomarkers; cognitive impairment; frailty; gait; older people
Authors: Vittorio Dibello; Frank Lobbezoo; Madia Lozupone; Rodolfo Sardone; Andrea Ballini; Giuseppe Berardino; Anita Mollica; Hélio José Coelho-Júnior; Giovanni De Pergola; Roberta Stallone; Antonio Dibello; Antonio Daniele; Massimo Petruzzi; Filippo Santarcangelo; Vincenzo Solfrizzi; Daniele Manfredini; Francesco Panza Journal: Geroscience Date: 2022-10-15 Impact factor: 7.581
Authors: Rossella Tatoli; Luisa Lampignano; Rossella Donghia; Fabio Castellana; Roberta Zupo; Ilaria Bortone; Sara De Nucci; Giuseppe Campanile; Domenico Lofù; Luigi Vimercati; Madia Lozupone; Giovanni De Pergola; Francesco Panza; Gianluigi Giannelli; Tommaso Di Noia; Heiner Boeing; Rodolfo Sardone Journal: Front Nutr Date: 2022-03-07