Literature DB >> 33898999

GD2-specific CAR T cells encapsulated in an injectable hydrogel control retinoblastoma and preserve vision.

Kai Wang1, Yuhui Chen2, Sarah Ahn2,3, Min Zheng1, Elisa Landoni2, Gianpietro Dotti2,3, Barbara Savoldo4,5, Zongchao Han6,7,8.   

Abstract

Retinoblastoma (RB) is a pediatric retinal tumor that overexpresses the ganglioside GD2. Although it is treatable in patients with early diagnosis, patients may lose one or two eyes. We generated GD2-specific chimeric antigen receptor T lymphocytes (GD2.CAR-Ts) and locally delivered them to mice with an in-situ grafting RB. When used in combination with the local release of interleukin (IL)-15 and an injectable hydrogel, we showed that GD2.CAR-Ts successfully eliminate RB tumor cells without impairment of the mouse vision.

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Year:  2020        PMID： 33898999      PMCID： PMC8061756          DOI： 10.1038/s43018-020-00119-y

Source DB:  PubMed          Journal:  Nat Cancer        ISSN： 2662-1347


  18 in total

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2.  Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma.

Authors:  Alice L Yu; Andrew L Gilman; M Fevzi Ozkaynak; Wendy B London; Susan G Kreissman; Helen X Chen; Malcolm Smith; Barry Anderson; Judith G Villablanca; Katherine K Matthay; Hiro Shimada; Stephan A Grupp; Robert Seeger; C Patrick Reynolds; Allen Buxton; Ralph A Reisfeld; Steven D Gillies; Susan L Cohn; John M Maris; Paul M Sondel
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3.  Chimeric antigen receptor T cells for sustained remissions in leukemia.

Authors:  Shannon L Maude; Noelle Frey; Pamela A Shaw; Richard Aplenc; David M Barrett; Nancy J Bunin; Anne Chew; Vanessa E Gonzalez; Zhaohui Zheng; Simon F Lacey; Yolanda D Mahnke; Jan J Melenhorst; Susan R Rheingold; Angela Shen; David T Teachey; Bruce L Levine; Carl H June; David L Porter; Stephan A Grupp
Journal:  N Engl J Med       Date:  2014-10-16       Impact factor: 91.245

4.  [Preliminary findings on the importance of the composition of the diet for a regular and balanced weight increase in young albino rats during growth].

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Journal:  Boll Soc Ital Biol Sper       Date:  1967-12-15

Review 5.  Treatment of Retinoblastoma in 2015: Agreement and Disagreement.

Authors:  David H Abramson; Carol L Shields; Francis L Munier; Guillermo L Chantada
Journal:  JAMA Ophthalmol       Date:  2015-11       Impact factor: 7.389

Review 6.  Retinoblastoma.

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Journal:  Lancet       Date:  2012-03-12       Impact factor: 79.321

7.  Optimization of molecular detection of GD2 synthase mRNA in retinoblastoma.

Authors:  Viviana E Laurent; Laura L Otero; Valeria Vazquez; Sandra Camarero; Mariano R Gabri; María Labraga; María T G De Dávila; Guillermo L Chantada; Daniel F Alonso
Journal:  Mol Med Rep       Date:  2010 Mar-Apr       Impact factor: 2.952

8.  Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma.

Authors:  Martin A Pule; Barbara Savoldo; G Doug Myers; Claudia Rossig; Heidi V Russell; Gianpietro Dotti; M Helen Huls; Enli Liu; Adrian P Gee; Zhuyong Mei; Eric Yvon; Heidi L Weiss; Hao Liu; Cliona M Rooney; Helen E Heslop; Malcolm K Brenner
Journal:  Nat Med       Date:  2008-11-02       Impact factor: 53.440

9.  A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma.

Authors:  S H Friend; R Bernards; S Rogelj; R A Weinberg; J M Rapaport; D M Albert; T P Dryja
Journal:  Nature       Date:  1986 Oct 16-22       Impact factor: 49.962
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  8 in total

Review 1.  Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity.

Authors:  Huan Cao; Lixia Duan; Yan Zhang; Jun Cao; Kun Zhang
Journal:  Signal Transduct Target Ther       Date:  2021-12-16

Review 2.  Short Review on Advances in Hydrogel-Based Drug Delivery Strategies for Cancer Immunotherapy.

Authors:  Hee Seung Seo; Chi-Pin James Wang; Wooram Park; Chun Gwon Park
Journal:  Tissue Eng Regen Med       Date:  2021-10-01       Impact factor: 4.451

3.  3D printed hydrogel scaffolds combining glutathione depletion-induced ferroptosis and photothermia-augmented chemodynamic therapy for efficiently inhibiting postoperative tumor recurrence.

Authors:  Wentao Dang; Wei-Chih Chen; Enguo Ju; Yanteng Xu; Kai Li; Haixia Wang; Kun Wang; Shixian Lv; Dan Shao; Yu Tao; Mingqiang Li
Journal:  J Nanobiotechnology       Date:  2022-06-07       Impact factor: 9.429

4.  Comprehensive Analysis of the Immune Cell Infiltration Landscape and Immune-Related Methylation in Retinoblastoma.

Authors:  Peiyao Mao; Yinchen Shen; Xun Xu; Jiawei Zhong
Journal:  Front Genet       Date:  2022-05-18       Impact factor: 4.772

5.  Fibrin gel enhances the antitumor effects of chimeric antigen receptor T cells in glioblastoma.

Authors:  Edikan A Ogunnaike; Alain Valdivia; Mostafa Yazdimamaghani; Ernesto Leon; Seema Nandi; Hannah Hudson; Hongwei Du; Simon Khagi; Zhen Gu; Barbara Savoldo; Frances S Ligler; Shawn Hingtgen; Gianpietro Dotti
Journal:  Sci Adv       Date:  2021-10-06       Impact factor: 14.136

6.  Delivery of CAR-T cells in a transient injectable stimulatory hydrogel niche improves treatment of solid tumors.

Authors:  Abigail K Grosskopf; Louai Labanieh; Dorota D Klysz; Gillie A Roth; Peng Xu; Omokolade Adebowale; Emily C Gale; Carolyn K Jons; John H Klich; Jerry Yan; Caitlin L Maikawa; Santiago Correa; Ben S Ou; Andrea I d'Aquino; Jennifer R Cochran; Ovijit Chaudhuri; Crystal L Mackall; Eric A Appel
Journal:  Sci Adv       Date:  2022-04-08       Impact factor: 14.136

7.  Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy.

Authors:  Hongjun Li; Zejun Wang; Edikan A Ogunnaike; Qing Wu; Guojun Chen; Quanyin Hu; Tianyuan Ci; Zhaowei Chen; Jinqiang Wang; Di Wen; Hongwei Du; Jie Jiang; Jie Sun; Xingcai Zhang; Gianpietro Dotti; Zhen Gu
Journal:  Natl Sci Rev       Date:  2021-09-21       Impact factor: 17.275

Review 8.  Treatment of Retinoblastoma: What Is the Latest and What Is the Future.

Authors:  Paula Schaiquevich; Jasmine H Francis; María Belén Cancela; Angel Montero Carcaboso; Guillermo L Chantada; David H Abramson
Journal:  Front Oncol       Date:  2022-04-01       Impact factor: 5.738
  8 in total

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