| Literature DB >> 33895780 |
Li Jiao1, Yun Yang1, Wenhai Yu1, Yuan Zhao1, Haiting Long1, Jiahong Gao1, Kaiyun Ding1, Chunxia Ma1, Jingmei Li1, Siwen Zhao1, Haixuan Wang1, Haiyan Li1, Mengli Yang1, Jingwen Xu1, Junbin Wang1, Jing Yang1, Dexuan Kuang1, Fangyu Luo1, Xingli Qian1, Longjiang Xu1, Bin Yin2, Wei Liu3, Hongqi Liu4, Shuaiyao Lu5,6, Xiaozhong Peng7,8.
Abstract
Neurological manifestations are frequently reported in the COVID-19 patients. Neuromechanism of SARS-CoV-2 remains to be elucidated. In this study, we explored the mechanisms of SARS-CoV-2 neurotropism via our established non-human primate model of COVID-19. In rhesus monkey, SARS-CoV-2 invades the CNS primarily via the olfactory bulb. Thereafter, viruses rapidly spread to functional areas of the central nervous system, such as hippocampus, thalamus, and medulla oblongata. The infection of SARS-CoV-2 induces the inflammation possibly by targeting neurons, microglia, and astrocytes in the CNS. Consistently, SARS-CoV-2 infects neuro-derived SK-N-SH, glial-derived U251, and brain microvascular endothelial cells in vitro. To our knowledge, this is the first experimental evidence of SARS-CoV-2 neuroinvasion in the NHP model, which provides important insights into the CNS-related pathogenesis of SARS-CoV-2.Entities:
Year: 2021 PMID： 33895780 DOI： 10.1038/s41392-021-00591-7
Source DB: PubMed Journal: Signal Transduct Target Ther ISSN： 2059-3635