Jiaqi Gao1, Huiping Liang2, Yun Qian1, Junhai Pan1, Wei Liu1, Weilin Qi1, Wei Zhou3, Xiaolong Ge4, Xianfa Wang1. 1. Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China. 2. Department of Medicine, Guangxi Medical College, Nanning, China. 3. Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China. zhouweisrrs@zju.edu.cn. 4. Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China. gxlmed@zju.edu.cn.
Abstract
BACKGROUND: Gastric cancer patients usually suffer from skeletal muscle depletion. The serum creatinine/ cystatin C ratio (CCR) is a new, simple tool that could serve as a biomarker of skeletal muscle mass. This study explored the ability of the preoperative CCR to predict postoperative complications in patients with gastric cancer. METHODS: A total of 309 patients with gastric cancer who were undergoing surgery were enrolled in this study. Univariate analyses were conducted to determine the potential risk factors for postoperative complications, and multivariate analyses were used to determine the independent influencing factors of postoperative complications. A receiver operating characteristic curve was conducted to identify the optimal cutoff value of the CCR. Patients were divided into two groups according to the critical value to investigate the relationship between the CCR and postoperative complications. RESULTS: Postoperative complications occurred in 87 patients. Multivariate analysis suggested that age, red blood cell level, lymphocyte count, cystatin C, CCR, and N factor were independent risk or protective factors for postoperative complications (P<0.001). The optimal cutoff value of the preoperative CCR was 7.117. Compared with the high preoperative CCR group, patients with a low preoperative CCR were more likely to have both mild complications (P<0.001) and major complications (P<0.001). CONCLUSIONS: The preoperative CCR can effectively predict postoperative complications in gastric cancer patients after surgery.
BACKGROUND:Gastric cancerpatients usually suffer from skeletal muscle depletion. The serum creatinine/ cystatin C ratio (CCR) is a new, simple tool that could serve as a biomarker of skeletal muscle mass. This study explored the ability of the preoperative CCR to predict postoperative complications in patients with gastric cancer. METHODS: A total of 309 patients with gastric cancer who were undergoing surgery were enrolled in this study. Univariate analyses were conducted to determine the potential risk factors for postoperative complications, and multivariate analyses were used to determine the independent influencing factors of postoperative complications. A receiver operating characteristic curve was conducted to identify the optimal cutoff value of the CCR. Patients were divided into two groups according to the critical value to investigate the relationship between the CCR and postoperative complications. RESULTS: Postoperative complications occurred in 87 patients. Multivariate analysis suggested that age, red blood cell level, lymphocyte count, cystatin C, CCR, and N factor were independent risk or protective factors for postoperative complications (P<0.001). The optimal cutoff value of the preoperative CCR was 7.117. Compared with the high preoperative CCR group, patients with a low preoperative CCR were more likely to have both mild complications (P<0.001) and major complications (P<0.001). CONCLUSIONS: The preoperative CCR can effectively predict postoperative complications in gastric cancerpatients after surgery.
Authors: Jeong Ah Hwang; Younghoon Song; Jaeun Shin; Eunjung Cho; Shin Young Ahn; Gang Jee Ko; Young Joo Kwon; Ji Eun Kim Journal: Front Med (Lausanne) Date: 2022-03-02