Literature DB >> 33893962

Reduced Expression of Extracellular Matrix Proteins in the Heart and Kidneys of Rats with Endotoxemia under the Effect of Actinonin.

D A Chepurnova1, E V Samoilova2, А G Fesenko1, А А Korotaeva1.   

Abstract

We studied modulation of the expression of extracellular matrix proteins under conditions of meprin inhibition in rats with LPS-induced endotoxemia. Endotoxemia increased the expression of type I, III, IV collagens and fibronectin in the renal tissue and type III and IV collagens in the heart. Meprin inhibitor actinonin reduced expression of both meprins and genes of extracellular matrix proteins, but the intensity of this effect in the heart and kidney was different. Inhibition of meprins in endotoxemia can prevent pathological remodeling of the extracellular matrix in the heart and kidney.

Entities:  

Keywords:  actinonin; collagens; extracellular matrix; gene expression; meprins

Year:  2021        PMID： 33893962     DOI： 10.1007/s10517-021-05146-y

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  13 in total

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6.  Targeted disruption of the meprin metalloproteinase beta gene protects against renal ischemia-reperfusion injury in mice.

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Review 7.  The pathogenesis of cardiac fibrosis.

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8.  The extracellular matrix in the kidney: a source of novel non-invasive biomarkers of kidney fibrosis?

Authors:  Federica Genovese; Alba A Manresa; Diana Julie Leeming; Morten Asser Karsdal; Peter Boor
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9.  Meprin Metalloprotease Deficiency Associated with Higher Mortality Rates and More Severe Diabetic Kidney Injury in Mice with STZ-Induced Type 1 Diabetes.

Authors:  John E Bylander; Faihaa Ahmed; Sabena M Conley; Jean-Marie Mwiza; Elimelda Moige Ongeri
Journal:  J Diabetes Res       Date:  2017-07-19       Impact factor: 4.011

10.  Accumulation of fibronectin in the heart after myocardial infarction: a putative stimulator of adhesion and proliferation of adipose-derived stem cells.

Authors:  A van Dijk; H W M Niessen; W Ursem; J W R Twisk; F C Visser; F J van Milligen
Journal:  Cell Tissue Res       Date:  2008-02-28       Impact factor: 5.249
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  1 in total

1.  Extracellular Matrix Components of Rat Lungs after Direct and Indirect Lung Injury.

Authors:  Е V Samoilova; D A Chepurnova; A G Fesenko; А А Korotaeva
Journal:  Bull Exp Biol Med       Date:  2022-02-17       Impact factor: 0.804
  1 in total

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