Katri Lahti1,2, Riitta Parkkola3, Päivi Jääsaari4, Leena Haataja5, Virva Saunavaara6,7. 1. Department of Pediatric Neurology, University of Turku and Turku University Hospital, P.O. Box 52, 20521, Turku, Finland. kaalah@utu.fi. 2. Department of Adolescent Psychiatry, Turku University Hospital, Turku, Finland. kaalah@utu.fi. 3. Department of Radiology, University of Turku and Turku University Hospital, Turku, Finland. 4. Department of Oral and Maxillofacial Diseases, Turku University Hospital, Turku, Finland. 5. Children's Hospital, and Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. 6. Department of Medical Physics, Turku University Hospital, Turku, Finland. 7. Turku PET Centre, Turku University Hospital, Turku, Finland.
Abstract
BACKGROUND: Diffusion tensor imaging is a widely used imaging method of brain white matter, but it is prone to imaging artifacts. The data corrections can affect the measured values. OBJECTIVE: To explore the impact of susceptibility correction on diffusion metrics. MATERIALS AND METHODS: A cohort of 27 healthy adolescents (18 boys, 9 girls, mean age 12.7 years) underwent 3-T MRI, and we collected two diffusion data sets (anterior-posterior). The data were processed both with and without susceptibility artifact correction. We derived fractional anisotropy, mean diffusivity and histogram data of fiber length distribution from both the corrected and uncorrected data, which were collected from the corpus callosum, corticospinal tract and cingulum bilaterally. RESULTS: Fractional anisotropy and mean diffusivity values significantly differed when comparing the pathways in all measured tracts. The fractional anisotropy values were lower and the mean diffusivity values higher in the susceptibility-corrected data than in the uncorrected data. We found a significant difference in total tract length in the corpus callosum and the corticospinal tract. CONCLUSION: This study indicates that susceptibility correction has a significant effect on measured fractional anisotropy, and on mean diffusivity values and tract lengths. To receive reliable and comparable results, the correction should be used systematically.
BACKGROUND: Diffusion tensor imaging is a widely used imaging method of brain white matter, but it is prone to imaging artifacts. The data corrections can affect the measured values. OBJECTIVE: To explore the impact of susceptibility correction on diffusion metrics. MATERIALS AND METHODS: A cohort of 27 healthy adolescents (18 boys, 9 girls, mean age 12.7 years) underwent 3-T MRI, and we collected two diffusion data sets (anterior-posterior). The data were processed both with and without susceptibility artifact correction. We derived fractional anisotropy, mean diffusivity and histogram data of fiber length distribution from both the corrected and uncorrected data, which were collected from the corpus callosum, corticospinal tract and cingulum bilaterally. RESULTS: Fractional anisotropy and mean diffusivity values significantly differed when comparing the pathways in all measured tracts. The fractional anisotropy values were lower and the mean diffusivity values higher in the susceptibility-corrected data than in the uncorrected data. We found a significant difference in total tract length in the corpus callosum and the corticospinal tract. CONCLUSION: This study indicates that susceptibility correction has a significant effect on measured fractional anisotropy, and on mean diffusivity values and tract lengths. To receive reliable and comparable results, the correction should be used systematically.
Authors: Matthew D Albaugh; Simon Ducharme; Sherif Karama; Richard Watts; John D Lewis; Catherine Orr; Tuong-Vi Nguyen; Robert C Mckinstry; Kelly N Botteron; Alan C Evans; James J Hudziak Journal: Dev Psychopathol Date: 2016-06-14
Authors: Donald J Hagler; SeanN Hatton; M Daniela Cornejo; Carolina Makowski; Damien A Fair; Anthony Steven Dick; Matthew T Sutherland; B J Casey; Deanna M Barch; Michael P Harms; Richard Watts; James M Bjork; Hugh P Garavan; Laura Hilmer; Christopher J Pung; Chelsea S Sicat; Joshua Kuperman; Hauke Bartsch; Feng Xue; Mary M Heitzeg; Angela R Laird; Thanh T Trinh; Raul Gonzalez; Susan F Tapert; Michael C Riedel; Lindsay M Squeglia; Luke W Hyde; Monica D Rosenberg; Eric A Earl; Katia D Howlett; Fiona C Baker; Mary Soules; Jazmin Diaz; Octavio Ruiz de Leon; Wesley K Thompson; Michael C Neale; Megan Herting; Elizabeth R Sowell; Ruben P Alvarez; Samuel W Hawes; Mariana Sanchez; Jerzy Bodurka; Florence J Breslin; Amanda Sheffield Morris; Martin P Paulus; W Kyle Simmons; Jonathan R Polimeni; Andre van der Kouwe; Andrew S Nencka; Kevin M Gray; Carlo Pierpaoli; John A Matochik; Antonio Noronha; Will M Aklin; Kevin Conway; Meyer Glantz; Elizabeth Hoffman; Roger Little; Marsha Lopez; Vani Pariyadath; Susan Rb Weiss; Dana L Wolff-Hughes; Rebecca DelCarmen-Wiggins; Sarah W Feldstein Ewing; Oscar Miranda-Dominguez; Bonnie J Nagel; Anders J Perrone; Darrick T Sturgeon; Aimee Goldstone; Adolf Pfefferbaum; Kilian M Pohl; Devin Prouty; Kristina Uban; Susan Y Bookheimer; Mirella Dapretto; Adriana Galvan; Kara Bagot; Jay Giedd; M Alejandra Infante; Joanna Jacobus; Kevin Patrick; Paul D Shilling; Rahul Desikan; Yi Li; Leo Sugrue; Marie T Banich; Naomi Friedman; John K Hewitt; Christian Hopfer; Joseph Sakai; Jody Tanabe; Linda B Cottler; Sara Jo Nixon; Linda Chang; Christine Cloak; Thomas Ernst; Gloria Reeves; David N Kennedy; Steve Heeringa; Scott Peltier; John Schulenberg; Chandra Sripada; Robert A Zucker; William G Iacono; Monica Luciana; Finnegan J Calabro; Duncan B Clark; David A Lewis; Beatriz Luna; Claudiu Schirda; Tufikameni Brima; John J Foxe; Edward G Freedman; Daniel W Mruzek; Michael J Mason; Rebekah Huber; Erin McGlade; Andrew Prescot; Perry F Renshaw; Deborah A Yurgelun-Todd; Nicholas A Allgaier; Julie A Dumas; Masha Ivanova; Alexandra Potter; Paul Florsheim; Christine Larson; Krista Lisdahl; Michael E Charness; Bernard Fuemmeler; John M Hettema; Hermine H Maes; Joel Steinberg; Andrey P Anokhin; Paul Glaser; Andrew C Heath; Pamela A Madden; Arielle Baskin-Sommers; R Todd Constable; Steven J Grant; Gayathri J Dowling; Sandra A Brown; Terry L Jernigan; Anders M Dale Journal: Neuroimage Date: 2019-08-12 Impact factor: 7.400