Douglas Magno Guimaraes1,2,3, Tamara Melo Nunes Ota4, Diego Assunção Calixto Da Silva4, Fabio De Lucas Da Silva Almeida4, Tatiana Dias Schalch5, Alessandro Melo Deana5, Jose Miguel Alves Junior6, Kristianne Porta Santos Fernandes5. 1. Pediatric Oncologic Hospital "Octavio Lobo", 1394 Quatorze de Abril side street, Belém, Pará, 66063-005, Brazil. Douglas_Guima@Hotmail.Com. 2. Dental School, University Center of Pará, 927 Nove de Janeiro street, Belém, Pará, 66060-575, Brazil. Douglas_Guima@Hotmail.Com. 3. Postgraduate Program in Biophotonics Applied to Health Sciences, Nove de Julho University- UNINOVE, 249 Vergueiro street, São Paulo, São Paulo, 01504-001, Brazil. Douglas_Guima@Hotmail.Com. 4. Dental School, University Center of Pará, 927 Nove de Janeiro street, Belém, Pará, 66060-575, Brazil. 5. Postgraduate Program in Biophotonics Applied to Health Sciences, Nove de Julho University- UNINOVE, 249 Vergueiro street, São Paulo, São Paulo, 01504-001, Brazil. 6. Pediatric Oncologic Hospital "Octavio Lobo", 1394 Quatorze de Abril side street, Belém, Pará, 66063-005, Brazil.
Abstract
PURPOSE: The objective of the present study was to compare the efficacy of photobiomodulation with low-level laser therapy (LLLT) or light-emitting diode therapy (LEDT) devices for the prevention and treatment of oral mucositis in pediatric patients diagnosed with acute lymphoblastic leukemia undergoing chemotherapy with high doses ofmethotrexate (MTX). METHODS:Eighty patients were randomly divided into two groups: LLLT and LEDT. Both protocols were applied with the same energy and radiant exposure. The protocols started in the beginning of high doses MTX and finished when the patients were discharged from the hospital or there was oral mucositis resolution. The oral mucositis was assessed during each session in accordance to the World Health Organization (WHO) score. The patients' self-assessed pain was scored on a visual analog scale (VAS). RESULTS: The incidence of oral mucositis was similar to LLLT and LEDT, 10% and 12.5%, respectively. Both groups required the same number of days to reach score of zero for mucositis and pain (p > 0. 05), and there was no significant difference in mean VAS between the groups. CONCLUSIONS: These findings suggest that LEDT has similar effects to LLLT to avoid and treat oral mucositis. Brazilian Clinical Trial Registry with #U1111-1221-5943.
RCT Entities:
PURPOSE: The objective of the present study was to compare the efficacy of photobiomodulation with low-level laser therapy (LLLT) or light-emitting diode therapy (LEDT) devices for the prevention and treatment of oral mucositis in pediatric patients diagnosed with acute lymphoblastic leukemia undergoing chemotherapy with high doses of methotrexate (MTX). METHODS: Eighty patients were randomly divided into two groups: LLLT and LEDT. Both protocols were applied with the same energy and radiant exposure. The protocols started in the beginning of high doses MTX and finished when the patients were discharged from the hospital or there was oral mucositis resolution. The oral mucositis was assessed during each session in accordance to the World Health Organization (WHO) score. The patients' self-assessed pain was scored on a visual analog scale (VAS). RESULTS: The incidence of oral mucositis was similar to LLLT and LEDT, 10% and 12.5%, respectively. Both groups required the same number of days to reach score of zero for mucositis and pain (p > 0. 05), and there was no significant difference in mean VAS between the groups. CONCLUSIONS: These findings suggest that LEDT has similar effects to LLLT to avoid and treat oral mucositis. Brazilian Clinical Trial Registry with #U1111-1221-5943.
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