BACKGROUND/AIMS: To explore risk factors of acute kidney injury (AKI) and its severity after liver transplantation. MATERIALS AND METHODS: This was a retrospective cohort of consecutive adults undergoing orthotopic liver transplantation (OLT) at a referral hospital. Risk factors for AKI from 1week post-liver transplantation and 4-week outcomes were analysed. Further analyses of factors that influenced the severity of AKI were also performed. RESULTS: A total of 204 patients were included. AKI was found in 55.4% of patients in the first week after OLT. Risk factors for AKI were recipient's sex, BMI, preoperative creatinine, preoperative hepatic encephalopathy, cold ischaemia time, duration of surgery, duration of inferior vena clamping, postoperative peak lactate and postoperative peak AST, which were higher in the AKI group. Four weeks after liver transplantation, 20.4% of AKI patients still had abnormal renal function and a mortality rate of 3.6%, and these values were significantly higher than those of patients without AKI (P<0.05). CONCLUSION: Preoperative, intraoperative and postoperative factors can all lead to AKI after OLT.
BACKGROUND/AIMS: To explore risk factors of acute kidney injury (AKI) and its severity after liver transplantation. MATERIALS AND METHODS: This was a retrospective cohort of consecutive adults undergoing orthotopic liver transplantation (OLT) at a referral hospital. Risk factors for AKI from 1week post-liver transplantation and 4-week outcomes were analysed. Further analyses of factors that influenced the severity of AKI were also performed. RESULTS: A total of 204 patients were included. AKI was found in 55.4% of patients in the first week after OLT. Risk factors for AKI were recipient's sex, BMI, preoperative creatinine, preoperative hepatic encephalopathy, cold ischaemia time, duration of surgery, duration of inferior vena clamping, postoperative peak lactate and postoperative peak AST, which were higher in the AKI group. Four weeks after liver transplantation, 20.4% of AKI patients still had abnormal renal function and a mortality rate of 3.6%, and these values were significantly higher than those of patients without AKI (P<0.05). CONCLUSION: Preoperative, intraoperative and postoperative factors can all lead to AKI after OLT.
Authors: A Karapanagiotou; C Kydona; C Dimitriadis; K Sgourou; T Giasnetsova; I Fouzas; G Imvrios; N Gritsi-Gerogianni Journal: Transplant Proc Date: 2012-11 Impact factor: 1.066
Authors: Paul M Palevsky; Kathleen D Liu; Patrick D Brophy; Lakhmir S Chawla; Chirag R Parikh; Charuhas V Thakar; Ashita J Tolwani; Sushrut S Waikar; Steven D Weisbord Journal: Am J Kidney Dis Date: 2013-03-15 Impact factor: 8.860
Authors: Kai Sun; Fu Hong; Yun Wang; Vatche G Agopian; Min Yan; Ronald W Busuttil; Randolph H Steadman; Victor W Xia Journal: Anesth Analg Date: 2017-11 Impact factor: 5.108
Authors: Adller G C Barreto; Elizabeth F Daher; Geraldo B Silva Junior; José Huygens P Garcia; Clarissa B A Magalhães; José Milton C Lima; Cyntia F G Viana; Eanes D B Pereira Journal: Ann Hepatol Date: 2015 Sep-Oct Impact factor: 2.400