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Literature DB >> 33893558

A formalism for modelling traction forces and cell shape evolution during cell migration in various biomedical processes.

Abstract

The phenomenological model for cell shape deformation and cell migration Chen (BMM 17:1429-1450, 2018), Vermolen and Gefen (BMM 12:301-323, 2012), is extended with the incorporation of cell traction forces and the evolution of cell equilibrium shapes as a result of cell differentiation. Plastic deformations of the extracellular matrix are modelled using morphoelasticity theory. The resulting partial differential differential equations are solved by the use of the finite element method. The paper treats various biological scenarios that entail cell migration and cell shape evolution. The experimental observations in Mak et al. (LC 13:340-348, 2013), where transmigration of cancer cells through narrow apertures is studied, are reproduced using a Monte Carlo framework.

Entities: Chemical

Keywords: Agent-based modelling; Cell geometry; Cell migration; Cellular traction forces; Finite-element method

Mesh：

Year: 2021 PMID： 33893558 PMCID： PMC8298374 DOI： 10.1007/s10237-021-01456-2

Source DB: PubMed Journal: Biomech Model Mechanobiol ISSN： 1617-7940

39 in total

Review 1. Re-epithelialization of adult skin wounds: Cellular mechanisms and therapeutic strategies.

Authors: Patricia Rousselle; Fabienne Braye; Guila Dayan
Journal: Adv Drug Deliv Rev Date: 2018-07-05 Impact factor: 15.470

2. Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines.

Authors: Vinay Swaminathan; Karthikeyan Mythreye; E Tim O'Brien; Andrew Berchuck; Gerard C Blobe; Richard Superfine
Journal: Cancer Res Date: 2011-06-03 Impact factor: 12.701

Review 3. Chemotaxis in cancer.

Authors: Evanthia T Roussos; John S Condeelis; Antonia Patsialou
Journal: Nat Rev Cancer Date: 2011-07-22 Impact factor: 60.716

Review 4. The shape of motile cells.

Authors: Alex Mogilner; Kinneret Keren
Journal: Curr Biol Date: 2009-09-15 Impact factor: 10.834

5. Elucidating mechanical transition effects of invading cancer cells with a subnucleus-scaled microfluidic serial dimensional modulation device.

Authors: Michael Mak; Cynthia A Reinhart-King; David Erickson
Journal: Lab Chip Date: 2013-02-07 Impact factor: 6.799

A formalism for modelling traction forces and cell shape evolution during cell migration in various biomedical processes.

Review 1. Re-epithelialization of adult skin wounds: Cellular mechanisms and therapeutic strategies.

2. Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines.

Review 3. Chemotaxis in cancer.

Review 4. The shape of motile cells.

5. Elucidating mechanical transition effects of invading cancer cells with a subnucleus-scaled microfluidic serial dimensional modulation device.

6. Nanomechanical analysis of cells from cancer patients.

7. An adhesion-dependent switch between mechanisms that determine motile cell shape.

Review 8. "Mesenchymal stem cells": fact or fiction, and implications in their therapeutic use.

9. A phenomenological model for cell and nucleus deformation during cancer metastasis.

10. Morpho-elasticity of inflammatory fibrosis: the case of capsular contracture.

1. Non-destructive monitoring of 3D cell cultures: new technologies and applications.