Yueh-Ying Han1, Erick Forno1, Selma F Witchel2, Michelle L Manni1, Edna Acosta-Pérez3, Glorisa Canino3, Juan C Celedón4. 1. Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania. 2. Division of Pediatric Endocrinology, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania. 3. Behavioral Sciences Research Institute, University of Puerto Rico, San Juan, Puerto Rico. 4. Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address: juan.celedon@chp.edu.
Abstract
BACKGROUND: Age- and sex-related differences in asthma may be due to changes in sex hormone levels. OBJECTIVE: To evaluate whether a change in free testosterone or free testosterone-to-estradiol ratio is associated with changes in lung function and eosinophils in the Puerto Rican youth. METHODS: We tested for the association between the change in sex hormone levels and change in lung function or change in eosinophils in a prospective study of 317 children (with and without asthma) followed up from ages 6 to 14 years to ages 10 to 20 years (146 females, 171 males) in San Juan, Puerto Rico. Serum levels of testosterone, estradiol, sex hormone-binding globulin, and progesterone were measured at 2 study visits, approximately 4.9 years apart. Using testosterone and sex hormone-binding globulin levels, we derived free testosterone and the free testosterone-to-estradiol ratio. Multivariable linear regression was used for the analysis of change in lung function and eosinophils, conducted separately by sex. RESULTS: In girls, each quartile increment in the free testosterone-to-estradiol ratio was associated with a 2.03% increment in percent predicted forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) between study visits. In males, each quartile increment in the free testosterone-to-estradiol ratio was associated with a 3.27% increment in percent predicted FEV1 and a 1.81% increment in percent predicted FEV1/FVC between study visits. In girls with asthma, an increased free testosterone-to-estradiol ratio was significantly associated with decreased eosinophils between visits (P=0.03). CONCLUSION: In Puerto Rican youth, increased free testosterone-to-estradiol ratio over time was associated with an increased FEV1/FVC in both sexes, and with an increased FEV1 in males.
BACKGROUND: Age- and sex-related differences in asthma may be due to changes in sex hormone levels. OBJECTIVE: To evaluate whether a change in free testosterone or free testosterone-to-estradiol ratio is associated with changes in lung function and eosinophils in the Puerto Rican youth. METHODS: We tested for the association between the change in sex hormone levels and change in lung function or change in eosinophils in a prospective study of 317 children (with and without asthma) followed up from ages 6 to 14 years to ages 10 to 20 years (146 females, 171 males) in San Juan, Puerto Rico. Serum levels of testosterone, estradiol, sex hormone-binding globulin, and progesterone were measured at 2 study visits, approximately 4.9 years apart. Using testosterone and sex hormone-binding globulin levels, we derived free testosterone and the free testosterone-to-estradiol ratio. Multivariable linear regression was used for the analysis of change in lung function and eosinophils, conducted separately by sex. RESULTS: In girls, each quartile increment in the free testosterone-to-estradiol ratio was associated with a 2.03% increment in percent predicted forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) between study visits. In males, each quartile increment in the free testosterone-to-estradiol ratio was associated with a 3.27% increment in percent predicted FEV1 and a 1.81% increment in percent predicted FEV1/FVC between study visits. In girls with asthma, an increased free testosterone-to-estradiol ratio was significantly associated with decreased eosinophils between visits (P=0.03). CONCLUSION: In Puerto Rican youth, increased free testosterone-to-estradiol ratio over time was associated with an increased FEV1/FVC in both sexes, and with an increased FEV1 in males.
Authors: K K Tsilidis; S Rohrmann; K A McGlynn; S J Nyante; D S Lopez; G Bradwin; M Feinleib; C E Joshu; N Kanarek; W G Nelson; E Selvin; E A Platz Journal: Andrology Date: 2013-09-30 Impact factor: 3.842
Authors: Abril Carbajal-García; Jorge Reyes-García; María F Casas-Hernández; Edgar Flores-Soto; Verónica Díaz-Hernández; Héctor Solís-Chagoyán; Bettina Sommer; Luis M Montaño Journal: Mol Cell Endocrinol Date: 2020-04-08 Impact factor: 4.102
Authors: Nienke M Vink; Dirkje S Postma; Jan P Schouten; Judith G M Rosmalen; H Marike Boezen Journal: J Allergy Clin Immunol Date: 2010-09 Impact factor: 10.793
Authors: Kristina Gaietto; Yueh-Ying Han; Erick Forno; Leonard B Bacharier; Wanda Phipatanakul; Theresa W Guilbert; Michael D Cabana; Kristie Ross; Joshua Blatter; Edna Acosta-Pérez; Gregory E Miller; Rafael E de la Hoz; Franziska J Rosser; Sandy Durrani; Glorisa Canino; Stephen R Wisniewski; Juan C Celedón Journal: Eur Respir J Date: 2022-05-12 Impact factor: 33.795
Authors: Ju Hee Kim; Jin Ah Kim; Eun Kyo Ha; Hye Mi Jee; Seung Won Lee; Mo Kyung Jung; Sanghoo Lee; Yoon Ho Shin; Eun-Gyong Yoo; Man Yong Han Journal: BMC Pediatr Date: 2022-03-17 Impact factor: 2.125