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Literature DB >> 33891902

Structural Insights into Transporter-Mediated Drug Resistance in Infectious Diseases.

Jonathan Kim¹, Rosemary J Cater¹, Brendon C Choy¹, Filippo Mancia².

Abstract

Infectious diseases present a major threat to public health globally. Pathogens can acquire resistance to anti-infectious agents via several means including transporter-mediated efflux. Typically, multidrug transporters feature spacious, dynamic, and chemically malleable binding sites to aid in the recognition and transport of chemically diverse substrates across cell membranes. Here, we discuss recent structural investigations of multidrug transporters involved in resistance to infectious diseases that belong to the ATP-binding cassette (ABC) superfamily, the major facilitator superfamily (MFS), the drug/metabolite transporter (DMT) superfamily, the multidrug and toxic compound extrusion (MATE) family, the small multidrug resistance (SMR) family, and the resistance-nodulation-division (RND) superfamily. These structural insights provide invaluable information for understanding and combatting multidrug resistance.

Entities: Chemical

Keywords: infectious disease; membrane transporters; multidrug resistance; structural biology

Mesh：

Substances：

Year: 2021 PMID： 33891902 PMCID： PMC8292200 DOI： 10.1016/j.jmb.2021.167005

Source DB: PubMed Journal: J Mol Biol ISSN： 0022-2836 Impact factor: 6.151

192 in total

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Authors: K Lewis
Journal: Curr Biol Date: 2000-09-21 Impact factor: 10.834

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Authors: Nir Fluman; Eitan Bibi
Journal: Biochim Biophys Acta Date: 2008-12-07

3. The multidrug resistance efflux complex, EmrAB from Escherichia coli forms a dimer in vitro.

Authors: Mikio Tanabe; Gerda Szakonyi; Katherine A Brown; Peter J F Henderson; Jon Nield; Bernadette Byrne
Journal: Biochem Biophys Res Commun Date: 2009-01-24 Impact factor: 3.575

4. Molecular Structure of the Human CFTR Ion Channel.

Authors: Fangyu Liu; Zhe Zhang; László Csanády; David C Gadsby; Jue Chen
Journal: Cell Date: 2017-03-23 Impact factor: 41.582

5. Structure of a cation-bound multidrug and toxic compound extrusion transporter.

Authors: Xiao He; Paul Szewczyk; Andrey Karyakin; Mariah Evin; Wen-Xu Hong; Qinghai Zhang; Geoffrey Chang
Journal: Nature Date: 2010-09-22 Impact factor: 49.962

6. The α-barrel tip region of Escherichia coli TolC homologs of Vibrio vulnificus interacts with the MacA protein to form the functional macrolide-specific efflux pump MacAB-TolC.

Authors: Minho Lee; Hyun-Lee Kim; Saemee Song; Minju Joo; Seunghwa Lee; Daeyoung Kim; Yoonsoo Hahn; Nam-Chul Ha; Kangseok Lee
Journal: J Microbiol Date: 2013-04-27 Impact factor: 3.422

7. Association of a Novel Mutation in the Plasmodium falciparum Chloroquine Resistance Transporter With Decreased Piperaquine Sensitivity.

Authors: Sonia Agrawal; Kara A Moser; Lindsay Morton; Michael P Cummings; Ankita Parihar; Ankit Dwivedi; Amol C Shetty; Elliott F Drabek; Christopher G Jacob; Philipp P Henrich; Christian M Parobek; Krisada Jongsakul; Rekol Huy; Michele D Spring; Charlotte A Lanteri; Suwanna Chaorattanakawee; Chanthap Lon; Mark M Fukuda; David L Saunders; David A Fidock; Jessica T Lin; Jonathan J Juliano; Christopher V Plowe; Joana C Silva; Shannon Takala-Harrison
Journal: J Infect Dis Date: 2017-08-15 Impact factor: 5.226

Structural Insights into Transporter-Mediated Drug Resistance in Infectious Diseases.

1. Translocases: a bacterial tunnel for drugs and proteins.

Review 2. Bacterial multidrug transport through the lens of the major facilitator superfamily.

3. The multidrug resistance efflux complex, EmrAB from Escherichia coli forms a dimer in vitro.

4. Molecular Structure of the Human CFTR Ion Channel.

5. Structure of a cation-bound multidrug and toxic compound extrusion transporter.

6. The α-barrel tip region of Escherichia coli TolC homologs of Vibrio vulnificus interacts with the MacA protein to form the functional macrolide-specific efflux pump MacAB-TolC.

7. Association of a Novel Mutation in the Plasmodium falciparum Chloroquine Resistance Transporter With Decreased Piperaquine Sensitivity.

8. MATE transport of the E. coli-derived genotoxin colibactin.

9. In vivo trp scanning of the small multidrug resistance protein EmrE confirms 3D structure models'.

10. Highly coupled transport can be achieved in free-exchange transport models.

1. Utilization of AlphaFold2 to Predict MFS Protein Conformations after Selective Mutation.

Review 2. Membrane Efflux Pumps of Pathogenic Vibrio Species: Role in Antimicrobial Resistance and Virulence.

3. Proton-driven alternating access in a spinster lipid transporter.