| Literature DB >> 3389054 |
M C Slootweg1, S C van Buul-Offers, M P Herrmann-Erlee, S A Duursma.
Abstract
GH action on cartilage is thought to be mainly mediated through the somatomedins produced by the liver. However, recent studies using cultured chondrocytes also point to a direct mitogenic action of GH. Besides, a direct action of GH on fetal rat tibiae has been demonstrated. This study is the first to show stimulation of thymidine uptake as well as DNA synthesis under the influence of physiological concentrations of human and chicken GH in fetal chicken osteoblasts in culture.Entities:
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Year: 1988 PMID： 3389054 DOI： 10.1530/acta.0.1180294
Source DB: PubMed Journal: Acta Endocrinol (Copenh) ISSN： 0001-5598