John K Peel1, Alana M Flexman2,3, Kyle R Kirkham1,4, Gianni R Lorello5,6,7,8. 1. Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada. 2. Department of Anesthesiology, Pharmacology &Therapeutics, The University of British Columbia, Vancouver, BC, Canada. 3. Department of Anesthesia, St. Paul's Hospital, Vancouver, BC, Canada. 4. Department of Anesthesia and Pain Management, Toronto Western Hospital - University Health Network, Toronto, ON, Canada. 5. Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada. gianni.lorello@uhn.ca. 6. Department of Anesthesia and Pain Management, Toronto Western Hospital - University Health Network, Toronto, ON, Canada. gianni.lorello@uhn.ca. 7. The Wilson Centre, University Health Network, Toronto, ON, Canada. gianni.lorello@uhn.ca. 8. Women's College Research Institute, Women's College Hospital, Toronto, ON, Canada. gianni.lorello@uhn.ca.