P B Bonnefoy1,2,3, L Janvier4, C Arede4, C Drouet4,5, D Harami4, S Marque6, R Ahond-Vionnet4. 1. Service de Médecine Nucléaire, Hôpital Pierre Bérégovoy, Nevers, France. p.benoit.bonnefoy@chu-st-etienne.fr. 2. Service de Médecine Nucléaire, CHU Saint-Etienne - Hôpital Nord, Saint Etienne, France. p.benoit.bonnefoy@chu-st-etienne.fr. 3. Service de Médecine Nucléaire, CHU de Saint-Etienne, 42055, Saint-Étienne, France. p.benoit.bonnefoy@chu-st-etienne.fr. 4. Service de Médecine Nucléaire, Hôpital Pierre Bérégovoy, Nevers, France. 5. Service de Médecine Nucléaire, Centre Georges-François Leclerc, Dijon, France. 6. Société CAPIONIS, Bordeaux, France.
Abstract
BACKGROUND: Cadmium-zinc-telluride (CZT) SPECT/CT cameras with large field of view offer a higher sensitivity than conventional Anger cameras. This prospective study aimed to determine the equivalence between a conventional protocol and a reduced acquisition time protocol for 201-Thallium myocardial perfusion imaging (MPI) using a whole-body CZT SPECT camera. METHODS AND RESULTS: Stress MPI was obtained for 103 consecutive patients on a DISCOVERY-CZT camera. Images were anonymized and post-processed to simulate a 25% (D75 dataset) and 50% (D50 dataset) decrease in total recorded counts. Concerning the number of segments displaying a tracer uptake < 70% of maximum intensity per patient, equivalence was demonstrated for both count-reduced datasets with a good inter-observer agreement (between 0.90 and 0.88). When comparing the full-vs-D75 datasets and full-vs-D50 datasets, mean difference was 0.06 segment (CI95: [- 0.15;0.27], P < 0.001) and 0.518 segment (CI95: [0.28;0.76], P < 0.001) respectively. Inter-observer agreement was also moderate to good concerning the number of pathological segments (between 0.6 and 0.7) and excellent for functional parameters. CONCLUSION: Whole-body CZT SPECT/CT cameras allow to reduce 201-Thallium MPI injected activity or acquisition time by 50% with an equivalence in the number of segments displaying a tracer uptake < 70% of maximum intensity and with a good inter-observer agreement.
BACKGROUND: Cadmium-zinc-telluride (CZT) SPECT/CT cameras with large field of view offer a higher sensitivity than conventional Anger cameras. This prospective study aimed to determine the equivalence between a conventional protocol and a reduced acquisition time protocol for 201-Thallium myocardial perfusion imaging (MPI) using a whole-body CZT SPECT camera. METHODS AND RESULTS: Stress MPI was obtained for 103 consecutive patients on a DISCOVERY-CZT camera. Images were anonymized and post-processed to simulate a 25% (D75 dataset) and 50% (D50 dataset) decrease in total recorded counts. Concerning the number of segments displaying a tracer uptake < 70% of maximum intensity per patient, equivalence was demonstrated for both count-reduced datasets with a good inter-observer agreement (between 0.90 and 0.88). When comparing the full-vs-D75 datasets and full-vs-D50 datasets, mean difference was 0.06 segment (CI95: [- 0.15;0.27], P < 0.001) and 0.518 segment (CI95: [0.28;0.76], P < 0.001) respectively. Inter-observer agreement was also moderate to good concerning the number of pathological segments (between 0.6 and 0.7) and excellent for functional parameters. CONCLUSION: Whole-body CZT SPECT/CT cameras allow to reduce 201-Thallium MPI injected activity or acquisition time by 50% with an equivalence in the number of segments displaying a tracer uptake < 70% of maximum intensity and with a good inter-observer agreement.
Authors: Andrew J Einstein; Ron Blankstein; Howard Andrews; Mathews Fish; Richard Padgett; Sean W Hayes; John D Friedman; Mehreen Qureshi; Harivony Rakotoarivelo; Piotr Slomka; Ryo Nakazato; Sabahat Bokhari; Marcello Di Carli; Daniel S Berman Journal: J Nucl Med Date: 2014-06-30 Impact factor: 10.057
Authors: Fabio P Esteves; Paolo Raggi; Russell D Folks; Zohar Keidar; J Wells Askew; Shmuel Rispler; Michael K O'Connor; Liudmilla Verdes; Ernest V Garcia Journal: J Nucl Cardiol Date: 2009-08-18 Impact factor: 5.952