| Literature DB >> 33888597 |
Meredith Yeager1,2, Mitchell J Machiela3, Prachi Kothiyal3,4, Michael Dean3,2, Clara Bodelon3, Shalabh Suman3,2, Mingyi Wang3,2, Lisa Mirabello3, Chase W Nelson5,6, Weiyin Zhou3,2, Cameron Palmer3,2, Bari Ballew3,2, Leandro M Colli3,7, Neal D Freedman3, Casey Dagnall3,2, Amy Hutchinson3,2, Vibha Vij3, Yosi Maruvka8,9, Maureen Hatch3, Iryna Illienko10, Yuri Belayev10, Nori Nakamura11, Vadim Chumak10, Elena Bakhanova10, David Belyi10, Victor Kryuchkov12, Ivan Golovanov12, Natalia Gudzenko10, Elizabeth K Cahoon3, Paul Albert3, Vladimir Drozdovitch3, Mark P Little3, Kiyohiko Mabuchi3, Chip Stewart8, Gad Getz8,9,13,14, Dimitry Bazyka10, Amy Berrington de Gonzalez3, Stephen J Chanock1.
Abstract
Effects of radiation exposure from the Chernobyl nuclear accident remain a topic of interest. We investigated germline de novo mutations (DNMs) in children born to parents employed as cleanup workers or exposed to occupational and environmental ionizing radiation after the accident. Whole-genome sequencing of 130 children (born 1987-2002) and their parents did not reveal an increase in the rates, distributions, or types of DNMs relative to the results of previous studies. We find no elevation in total DNMs, regardless of cumulative preconception gonadal paternal [mean = 365 milligrays (mGy), range = 0 to 4080 mGy] or maternal (mean = 19 mGy, range = 0 to 550 mGy) exposure to ionizing radiation. Thus, we conclude that, over this exposure range, evidence is lacking for a substantial effect on germline DNMs in humans, suggesting minimal impact from transgenerational genetic effects.Entities:
Year: 2021 PMID： 33888597 PMCID： PMC9398532 DOI： 10.1126/science.abg2365
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 63.714