Shilan Li1, Anna Mou2, Xin Li1, Yan Guo3, Qingwei Song1, Ailian Liu1, Zhiyong Li1. 1. Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian City, Liaoning Province, PR China. 2. Department of Radiology, Affiliated Hospital of Medical School, University of Electronic Science and Technology of China, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, PR China. 3. GE Healthcare, Shenyang City, Liaoning Province, PR China.
Abstract
BACKGROUND: Intravoxel incoherent motion imaging (IVIM) can non-invasively evaluate diffusion and microvascular perfusion. PURPOSE: To explore the myocardium microcirculation of a healthy Chinese population by using cardiac magnetic resonance (CMR) IVIM. MATERIAL AND METHODS: A total of 80 healthy volunteers (44 men, 36 women) who underwent 3.0-T CMR examination were enrolled. All participants had cardiac cine imaging and short-axis CMR-IVIM of the left ventricle (LV) using multiple b-values. The consistency of the IVIM parameters was assessed by intraclass correlation coefficient (ICC) and the Bland-Altman test. Spearman correlation analysis was performed between IVIM parameters and age, and body mass index (BMI). The differences of IVIM parameters were analyzed between gender and different ages. RESULTS: LV end-diastolic volume (EDV), end-systolic volume (ESV), LVmass, cardiac output (CO), and BMI in the male group were higher than those in the female group (P<0.05). IVIM parameters had good intra-observer and inter-observer consistency (≥0.75). Bland-Altman analysis also showed good intra-observer and inter-observer consistency. ADCfast decreased with increasing female age (rs = -0.37; P = 0.01), while IVIM parameters had no correlation with BMI regardless of sex. ADCfast in the female group had a statistical difference between different age groups. The ADCslow and f in the male group were lower than those in the female group (P<0.05); however, there was no statistical difference in ADCfast between genders. CONCLUSION: IVIM parameters in healthy Chinese volunteers provided good consistency. There was a negative correlation between ADCfast and age in the female group.
BACKGROUND: Intravoxel incoherent motion imaging (IVIM) can non-invasively evaluate diffusion and microvascular perfusion. PURPOSE: To explore the myocardium microcirculation of a healthy Chinese population by using cardiac magnetic resonance (CMR) IVIM. MATERIAL AND METHODS: A total of 80 healthy volunteers (44 men, 36 women) who underwent 3.0-T CMR examination were enrolled. All participants had cardiac cine imaging and short-axis CMR-IVIM of the left ventricle (LV) using multiple b-values. The consistency of the IVIM parameters was assessed by intraclass correlation coefficient (ICC) and the Bland-Altman test. Spearman correlation analysis was performed between IVIM parameters and age, and body mass index (BMI). The differences of IVIM parameters were analyzed between gender and different ages. RESULTS: LV end-diastolic volume (EDV), end-systolic volume (ESV), LVmass, cardiac output (CO), and BMI in the male group were higher than those in the female group (P<0.05). IVIM parameters had good intra-observer and inter-observer consistency (≥0.75). Bland-Altman analysis also showed good intra-observer and inter-observer consistency. ADCfast decreased with increasing female age (rs = -0.37; P = 0.01), while IVIM parameters had no correlation with BMI regardless of sex. ADCfast in the female group had a statistical difference between different age groups. The ADCslow and f in the male group were lower than those in the female group (P<0.05); however, there was no statistical difference in ADCfast between genders. CONCLUSION: IVIM parameters in healthy Chinese volunteers provided good consistency. There was a negative correlation between ADCfast and age in the female group.