Jan Bardon1, Sandra Kurcova1, Monika Chudackova1, Pavel Otruba1, David Krahulik2, Martin Nevrly1, Petr Kanovsky1, Jana Zapletalova3, Jan Valosek1,4, Petr Hlustik1, Miroslav Vastik1, Marketa Vecerkova1, Lenka Hvizdosova1, Katerina Mensikova1, Egon Kurca5, Stefan Sivak5. 1. Department of Neurology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic. 2. Department of Neurosurgery, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic. 3. Department of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic. 4. Department of Biomedical Engineering, University Hospital Olomouc, Czech Republic. 5. Department of Neurology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava and University Hospital Martin, Martin, Slovak Republic.
Abstract
BACKGROUND: In this study we evaluated the impact of location of deep brain stimulation electrode active contact in different parts of the subthalamic nucleus on improvement of non-motor symptoms in patients with Parkinson's disease. METHODS: The subthalamic nucleus was divided into two (dorsolateral/ventromedial) and three (dorsolateral, medial, ventromedial) parts. 37 deep brain stimulation electrodes were divided according to their active contact location. Correlation between change in non-motor symptoms before and one and four months after deep brain stimulation electrode implantation and the location of active contact was made. RESULTS: In dividing the subthalamic nucleus into three parts, no electrode active contact was placed ventromedially, 28 active contacts were located in the medial part and 9 contacts were placed dorsolaterally. After one and four months, no significant difference was found between medial and dorsolateral positions. In the division of the subthalamic nucleus into two parts, 13 contacts were located in the ventromedial part and 24 contacts were placed in the dorsolateral part. After one month, significantly greater improvement in the Non-motor Symptoms Scale for Parkinson's disease (P=0.045) was found on dorsolateral left-sided stimulation, but no significant differences between the ventromedial and dorsolateral positions were found on the right side. CONCLUSION: This study demonstrated the relationship between improvement of non-motor symptoms and the side (hemisphere, left/right) of the deep brain stimulation electrode active contact, rather than its precise location within specific parts of the subthalamic nucleus in patients treated for advanced Parkinson's disease.
BACKGROUND: In this study we evaluated the impact of location of deep brain stimulation electrode active contact in different parts of the subthalamic nucleus on improvement of non-motor symptoms in patients with Parkinson's disease. METHODS: The subthalamic nucleus was divided into two (dorsolateral/ventromedial) and three (dorsolateral, medial, ventromedial) parts. 37 deep brain stimulation electrodes were divided according to their active contact location. Correlation between change in non-motor symptoms before and one and four months after deep brain stimulation electrode implantation and the location of active contact was made. RESULTS: In dividing the subthalamic nucleus into three parts, no electrode active contact was placed ventromedially, 28 active contacts were located in the medial part and 9 contacts were placed dorsolaterally. After one and four months, no significant difference was found between medial and dorsolateral positions. In the division of the subthalamic nucleus into two parts, 13 contacts were located in the ventromedial part and 24 contacts were placed in the dorsolateral part. After one month, significantly greater improvement in the Non-motor Symptoms Scale for Parkinson's disease (P=0.045) was found on dorsolateral left-sided stimulation, but no significant differences between the ventromedial and dorsolateral positions were found on the right side. CONCLUSION: This study demonstrated the relationship between improvement of non-motor symptoms and the side (hemisphere, left/right) of the deep brain stimulation electrode active contact, rather than its precise location within specific parts of the subthalamic nucleus in patients treated for advanced Parkinson's disease.
Entities:
Keywords:
Parkinson's disease; deep brain stimulation; non-motor symptoms
Authors: Haidar Salimi Dafsari; Jan Niklas Petry-Schmelzer; K Ray-Chaudhuri; Keyoumars Ashkan; Luca Weis; Till A Dembek; Michael Samuel; Alexandra Rizos; Monty Silverdale; Michael T Barbe; Gereon R Fink; Julian Evans; Pablo Martinez-Martin; Angelo Antonini; Veerle Visser-Vandewalle; Lars Timmermann Journal: Brain Stimul Date: 2018-03-16 Impact factor: 8.955
Authors: Jan Niklas Petry-Schmelzer; Max Krause; Till A Dembek; Andreas Horn; Julian Evans; Keyoumars Ashkan; Alexandra Rizos; Monty Silverdale; Wibke Schumacher; Carolin Sack; Philipp A Loehrer; Gereon R Fink; Erich T Fonoff; Pablo Martinez-Martin; Angelo Antonini; Michael T Barbe; Veerle Visser-Vandewalle; K Ray-Chaudhuri; Lars Timmermann; Haidar S Dafsari Journal: Brain Date: 2019-11-01 Impact factor: 13.501
Authors: Christopher R Honey; Clement Hamani; Suneil K Kalia; Tejas Sankar; Marina Picillo; Renato P Munhoz; Alfonso Fasano; Michel Panisset Journal: Can J Neurol Sci Date: 2016-03-15 Impact factor: 2.104
Authors: Christopher G Goetz; Barbara C Tilley; Stephanie R Shaftman; Glenn T Stebbins; Stanley Fahn; Pablo Martinez-Martin; Werner Poewe; Cristina Sampaio; Matthew B Stern; Richard Dodel; Bruno Dubois; Robert Holloway; Joseph Jankovic; Jaime Kulisevsky; Anthony E Lang; Andrew Lees; Sue Leurgans; Peter A LeWitt; David Nyenhuis; C Warren Olanow; Olivier Rascol; Anette Schrag; Jeanne A Teresi; Jacobus J van Hilten; Nancy LaPelle Journal: Mov Disord Date: 2008-11-15 Impact factor: 10.338
Authors: Sandra Kurcova; Jan Bardon; Miroslav Vastik; Marketa Vecerkova; Monika Frolova; Lenka Hvizdosova; Martin Nevrly; Katerina Mensikova; Pavel Otruba; David Krahulik; Egon Kurca; Stefan Sivak; Jana Zapletalova; Petr Kanovsky Journal: Medicine (Baltimore) Date: 2018-02 Impact factor: 1.889