Preeti Kar1, Jess E Reynolds2, Melody N Grohs3, Rhonda C Bell4, Megan Jarman5, Deborah Dewey6, Catherine Lebel7. 1. Alberta Children's Hospital Research Institute, Canada; Hotchkiss Brain Institute, University of Calgary, Canada. Electronic address: preeti.kar@ucalgary.ca. 2. Alberta Children's Hospital Research Institute, Canada; Hotchkiss Brain Institute, University of Calgary, Canada; Departments of Radiology, University of Calgary, Canada. Electronic address: jessica.reynolds@ucalgary.ca. 3. Alberta Children's Hospital Research Institute, Canada; Hotchkiss Brain Institute, University of Calgary, Canada. Electronic address: melody.grohs@ucalgary.ca. 4. Department of Agricultural, Food & Nutritional Science, University of Alberta, Canada. Electronic address: bellr@ualberta.ca. 5. Department of Agricultural, Food & Nutritional Science, University of Alberta, Canada. Electronic address: m.jarman@aston.ac.uk. 6. Alberta Children's Hospital Research Institute, Canada; Hotchkiss Brain Institute, University of Calgary, Canada; Department of Pediatrics, University of Calgary, Canada; Department of Community Health Sciences, University of Calgary, Canada. Electronic address: dmdewey@ucalgary.ca. 7. Alberta Children's Hospital Research Institute, Canada; Hotchkiss Brain Institute, University of Calgary, Canada; Departments of Radiology, University of Calgary, Canada. Electronic address: clebel@ucalgary.ca.
Abstract
INTRODUCTION: Associations between breastfeeding and brain development, in the context of child, perinatal, and sociodemographic variables, remain unclear. This study investigated whether exclusive breastfeeding for the first 6 months and total duration of breastfeeding were associated with brain white matter microstructure in young children. METHODS: This study included 85 typically developing children (42 males) born to 83 mothers that were predominantly white, highly educated, and in high income households. Children underwent their first diffusion tensor imaging scan between ages 2.34 and 6.97 years; some children returned multiple times, providing a total of 331 datasets. Feeding information was collected from mothers at 3, 6, and 12 months postpartum and at their child's scan to calculate breastfeeding status at 6 months (exclusive or not) as well as total duration of any breastfeeding. Linear regression was used to investigate associations between breastfeeding exclusivity/duration and fractional anisotropy (FA) for the whole brain and 10 individual white matter tracts. RESULTS: Breastfeeding exclusivity and duration were associated with global and regional white matter microstructure, even after controlling for perinatal and sociodemographic factors. Greater exclusivity was associated with higher FA in females and lower FA in males. CONCLUSIONS: These findings suggest white matter differences associated with breastfeeding that differ by sex. These may stem from different trajectories in white matter development between males and females in early childhood and suggest possible long-term white matter differences associated with breastfeeding.
INTRODUCTION: Associations between breastfeeding and brain development, in the context of child, perinatal, and sociodemographic variables, remain unclear. This study investigated whether exclusive breastfeeding for the first 6 months and total duration of breastfeeding were associated with brain white matter microstructure in young children. METHODS: This study included 85 typically developing children (42 males) born to 83 mothers that were predominantly white, highly educated, and in high income households. Children underwent their first diffusion tensor imaging scan between ages 2.34 and 6.97 years; some children returned multiple times, providing a total of 331 datasets. Feeding information was collected from mothers at 3, 6, and 12 months postpartum and at their child's scan to calculate breastfeeding status at 6 months (exclusive or not) as well as total duration of any breastfeeding. Linear regression was used to investigate associations between breastfeeding exclusivity/duration and fractional anisotropy (FA) for the whole brain and 10 individual white matter tracts. RESULTS: Breastfeeding exclusivity and duration were associated with global and regional white matter microstructure, even after controlling for perinatal and sociodemographic factors. Greater exclusivity was associated with higher FA in females and lower FA in males. CONCLUSIONS: These findings suggest white matter differences associated with breastfeeding that differ by sex. These may stem from different trajectories in white matter development between males and females in early childhood and suggest possible long-term white matter differences associated with breastfeeding.
Authors: Ana Nieto-Ruiz; José A García-Santos; Juan Verdejo-Román; Estefanía Diéguez; Natalia Sepúlveda-Valbuena; Florian Herrmann; Tomás Cerdó; Roser De-Castellar; Jesús Jiménez; Mercedes G Bermúdez; Miguel Pérez-García; M Teresa Miranda; M Carmen López-Sabater; Andrés Catena; Cristina Campoy Journal: Front Nutr Date: 2022-03-09
Authors: Steffen van Heijningen; Giorgio Karapetsas; Eline M van der Beek; Gertjan van Dijk; Lidewij Schipper Journal: Front Neurosci Date: 2022-04-29 Impact factor: 4.677