Giacomo Calzetti1,2, Anna Sophie Mursch-Edlmayr3, Ahmed M Bata4,5, Nicola Ungaro1, Paolo Mora1, Jacqueline Chua6,7, Doreen Schmidl4, Matthias Bolz3, Gerhard Garhöfer4, Stefano Gandolfi1, Leopold Schmetterer2,4,6,7,8,9,10,11, Damon Wong6,10,11. 1. Department of Ophthalmology, University Hospital of Parma, Parma, Italy. 2. Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland. 3. Department of Ophthalmology, Kepler University Clinic, Johannes Kepler University, Linz, Austria. 4. Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria. 5. Vienna Health Association, Kaiser Franz Josef (Favoriten) Hospital, Vienna, Austria. 6. Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore. 7. Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore. 8. School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore, Singapore. 9. Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria. 10. SERI-NTU Advanced Ocular Engineering (STANCE), Singapore, Singapore. 11. NTU Institute of Health Technologies, Singapore, Singapore.
Abstract
PURPOSE: We aimed to describe the global and localized correlations among visual field (VF) sensitivity, optic nerve head (ONH) perfusion measured by laser speckle flowgraphy (LSFG) and neural structure measured by optical coherence tomography (OCT) in open-angle glaucoma (OAG) and to compare the floor effect for LSFG and OCT. METHODS: Cross-sectional, multicenter study including one eye each from fifty OAG patients (mean age 69.3 years; average VF mean deviation, MD, -8.5 dB, range -25.17 to 0.85 dB) and fifty-one controls. Patients underwent SITA standard 24-2 automated perimetry and measurement of ONH perfusion, peripapillary retinal nerve fibre layer thickness (RNFLT) and macular ganglion cell-inner plexiform layer thickness (GCIPLT). We tested the presence of a significant change (breakpoint) in the correlation slope with VF sensitivity to assess floor effect. RESULTS: The correlation between the LSFG parameter Mean All (MA) of the global disc area and MD (r = 0.56, p < 0.001) did not show a breakpoint, in contrast to the correlations between MD and OCT global parameters, which showed breakpoints at -8.53 and -4.05 dB for RNFLT and GCIPLT, respectively. Global and localized correlations with VF sensitivity were stronger for LSFG compared to OCT. In particular, LSFG outperformed OCT in the correlation with the central VF sector (r = 0.50, p < 0.001 and r = 0.06, p = 0.67 for MA and RNFLT, respectively). CONCLUSION: The global and sectoral correlations with VF sensitivity and the favourable floor effect compared to OCT indicate LSFG as a promising tool to monitor progression particularly in late-stage glaucoma. Further longitudinal studies are warranted.
PURPOSE: We aimed to describe the global and localized correlations among visual field (VF) sensitivity, optic nerve head (ONH) perfusion measured by laser speckle flowgraphy (LSFG) and neural structure measured by optical coherence tomography (OCT) in open-angle glaucoma (OAG) and to compare the floor effect for LSFG and OCT. METHODS: Cross-sectional, multicenter study including one eye each from fifty OAG patients (mean age 69.3 years; average VF mean deviation, MD, -8.5 dB, range -25.17 to 0.85 dB) and fifty-one controls. Patients underwent SITA standard 24-2 automated perimetry and measurement of ONH perfusion, peripapillary retinal nerve fibre layer thickness (RNFLT) and macular ganglion cell-inner plexiform layer thickness (GCIPLT). We tested the presence of a significant change (breakpoint) in the correlation slope with VF sensitivity to assess floor effect. RESULTS: The correlation between the LSFG parameter Mean All (MA) of the global disc area and MD (r = 0.56, p < 0.001) did not show a breakpoint, in contrast to the correlations between MD and OCT global parameters, which showed breakpoints at -8.53 and -4.05 dB for RNFLT and GCIPLT, respectively. Global and localized correlations with VF sensitivity were stronger for LSFG compared to OCT. In particular, LSFG outperformed OCT in the correlation with the central VF sector (r = 0.50, p < 0.001 and r = 0.06, p = 0.67 for MA and RNFLT, respectively). CONCLUSION: The global and sectoral correlations with VF sensitivity and the favourable floor effect compared to OCT indicate LSFG as a promising tool to monitor progression particularly in late-stage glaucoma. Further longitudinal studies are warranted.
Authors: Gerhard Garhöfer; Ahmed M Bata; Alina Popa-Cherecheanu; Anton Hommer; Clemens Vass; Hemma Resch; Doreen Schmidl; René M Werkmeister; Leopold Schmetterer Journal: Int J Mol Sci Date: 2022-09-05 Impact factor: 6.208
Authors: Damon Wong; Jacqueline Chua; Bingyao Tan; Xinwen Yao; Rachel Chong; Chelvin C A Sng; Rahat Husain; Tin Aung; David Garway-Heath; Leopold Schmetterer Journal: Invest Ophthalmol Vis Sci Date: 2021-12-01 Impact factor: 4.799