Syeda Sahra1,2, Abdullah Jahangir3, Qasim Zafar Iqbal3, Neville Mobarakai3, Allison Glaser3, Ahmad Jahangir4. 1. Staten Island University Hospital, Staten Island, NY, 10305, USA. ssahra@northwell.edu. 2. Department of Internal Medicine, Hofstra School of Medicine, Staten Island University Hospital, 475 Seaview Avenue, Staten Island, NY, 10305, USA. ssahra@northwell.edu. 3. Staten Island University Hospital, Staten Island, NY, 10305, USA. 4. King Edward Medical University, Lahore, 54000, Pakistan.
Abstract
BACKGROUND: There is a high prevalence of malaria and viral hepatitis in South Africa. Co-infection with Plasmodium malaria (leading to cerebral malaria) and hepatitis E virus (HEV) is a rare phenomenon. CASE PRESENTATION: A 33-year-old African American male with no past medical history developed altered mental status on his return from Ivory Coast. His blood tests were significant for renal and liver failure and a high Plasmodium parasite burden of 33% on the blood smear. Interestingly, he also had a positive result for hepatitis E IgM. The patient was effectively treated with aggressive hydration and intravenous (IV) artesunate. CONCLUSION: Our report is the first to our knowledge in the cerebral malaria literature on a patient with hepatitis E co-infection. This exciting case emphasizes the importance of considering all kinds of endemic infectious diseases when evaluating sick returning travelers presenting to the emergency department.
BACKGROUND: There is a high prevalence of malaria and viral hepatitis in South Africa. Co-infection with Plasmodiummalaria (leading to cerebral malaria) and hepatitis E virus (HEV) is a rare phenomenon. CASE PRESENTATION: A 33-year-old African American male with no past medical history developed altered mental status on his return from Ivory Coast. His blood tests were significant for renal and liver failure and a high Plasmodium parasite burden of 33% on the blood smear. Interestingly, he also had a positive result for hepatitis E IgM. The patient was effectively treated with aggressive hydration and intravenous (IV) artesunate. CONCLUSION: Our report is the first to our knowledge in the cerebral malaria literature on a patient with hepatitis E co-infection. This exciting case emphasizes the importance of considering all kinds of endemic infectious diseases when evaluating sick returning travelers presenting to the emergency department.
Entities:
Keywords:
COVID-19; Cerebral malaria; HEV; Hepatitis E virus; Plasmodium falciparum
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