Marie-Françoise Leonard1, Hector Rodriguez-Villalobos2, Nadia Boisen3, Flemming Scheutz3, Pierre-François Laterre4, Philippe Hantson5. 1. Laboratoire Synlab, 4020, Liège, Belgium. 2. Department of Microbiology, Cliniques universitaires St-Luc, Université catholique de Louvain, Brussels, Belgium. 3. Department of Bacteria, Parasites and Fungi, Statens Serum Institut, The International Centre for Reference and Research on Escherichia and Klebsiella, Copenhagen, Denmark. 4. Department of Intensive Care, Cliniques universitaires St-Luc, Université catholique de Louvain, Brussels, Belgium. 5. Department of Intensive Care, Cliniques universitaires St-Luc, Université catholique de Louvain, Brussels, Belgium. philippe.hantson@uclouvain.be.
Abstract
BACKGROUND: Native valves infective endocarditis due to Escherichia coli is still a rare disease and a particular virulence of some E.coli isolate may be suspected. CASE PRESENTATION: A 79-year-old woman presented during the post-operative period of an orthopedic surgery a urinary tract infection following obstructive ureteral lithiasis. E. coli was isolated from a pure culture of urine and blood sampled simultaneously. After evidence of sustained E.coli septicemia, further investigations revealed acute cholecystitis with the same micro-organism in biliary drainage and a native valve mitral endocarditis. E.coli was identified as O2:K7:H6, phylogenetic group B2, ST141, and presented several putative and proven virulence genes. The present isolate can be classified as both extra-intestinal pathogenic E.coli (ExPECJJ) and uropathogenic E. coli (UPECHM). CONCLUSIONS: The relationship between the virulent factors present in ExPEC strains and some serotypes of E. coli that could facilitate the adherence to cardiac valves warrants further investigation.
BACKGROUND: Native valves infective endocarditis due to Escherichia coli is still a rare disease and a particular virulence of some E.coli isolate may be suspected. CASE PRESENTATION: A 79-year-old woman presented during the post-operative period of an orthopedic surgery a urinary tract infection following obstructive ureteral lithiasis. E. coli was isolated from a pure culture of urine and blood sampled simultaneously. After evidence of sustained E.coli septicemia, further investigations revealed acute cholecystitis with the same micro-organism in biliary drainage and a native valve mitral endocarditis. E.coli was identified as O2:K7:H6, phylogenetic group B2, ST141, and presented several putative and proven virulence genes. The present isolate can be classified as both extra-intestinal pathogenic E.coli (ExPECJJ) and uropathogenic E. coli (UPECHM). CONCLUSIONS: The relationship between the virulent factors present in ExPEC strains and some serotypes of E. coli that could facilitate the adherence to cardiac valves warrants further investigation.
Authors: R Micol; O Lortholary; F Jaureguy; S Bonacorsi; E Bingen; A Lefort; N Mémain; O Bouchaud; C Larroche Journal: Clin Microbiol Infect Date: 2006-05 Impact factor: 8.067
Authors: Martina Bielaszewska; Roswitha Schiller; Lydia Lammers; Andreas Bauwens; Angelika Fruth; Barbara Middendorf; M Alexander Schmidt; Phillip I Tarr; Ulrich Dobrindt; Helge Karch; Alexander Mellmann Journal: EMBO Mol Med Date: 2014-01-10 Impact factor: 12.137