Liulin Wang1,2, Xiaobin Cheng1,2, Qiufen Dong1,2, Chenliang Zhou3, Yeming Wang4, Bin Song5, Weinan Li2,6, Min Wang1,2, Rui Qin1,2, Qi Long1,2, Juan Liu1,2, Jing Li1,2, Dan Li1,2, Gang Li7,8, Yuanming Ba9,10. 1. Department of Critical Care Medicine, Hubei Provincial Hospital of Tranditional Chinese Medicine, Wuhan, China. 2. Hubei Provincial Academy of Tranditional Chinese Medicine, Wuhan, China. 3. Department of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, China. 4. Department of Critical Care Medicine, Hubei Provincial Hospital of Integrated Chinese & Western Medicine, Wuhan, China. 5. Department of Critical Care Medicine, Jin Yin-tan Hospital, Wuhan, China. 6. Nephrology Department, Hubei Provincial Hospital of Tranditional Chinese Medicine, Wuhan, China. 7. Department of Critical Care Medicine, Hubei Provincial Hospital of Tranditional Chinese Medicine, Wuhan, China. marty007@163.com. 8. Hubei Provincial Academy of Tranditional Chinese Medicine, Wuhan, China. marty007@163.com. 9. Hubei Provincial Academy of Tranditional Chinese Medicine, Wuhan, China. 1723426138@qq.com. 10. Nephrology Department, Hubei Provincial Hospital of Tranditional Chinese Medicine, Wuhan, China. 1723426138@qq.com.
Abstract
BACKGROUND: The current coronavirus disease 2019 (COVID-19) is a public health emergency. In this study, we aimed to evaluate the risk factors for mortality in severe and critical COVID-19 patients. METHODS: We performed a retrospective study of patients diagnosed with severe and critical COVID-19 from four hospitals in Wuhan, China, by evaluating the clinical characteristics and laboratory results, and using Cox proportional hazards model to assess the risk factors involved in disease progression. RESULTS: In total, 446 patients with COVID-19 were enrolled. The study indicated a high mortality rate (20.2%) in severe and critical COVID-19 patients. At the time of admission, all patients required oxygen therapy, and 52 (12%) required invasive mechanical ventilation, of which 50 (96%) died. The univariate Cox proportional hazards model showed a white blood cell count of more than 10 × 109/L (HR 3.993,95%CI 2.469 to 6.459) that correlated with an increased mortality rate. The multivariable Cox proportional hazards model demonstrated that older age (HR 1.066, 95% CI 1.043 to 1.089) and higher white blood cell count (HR 1.135, 95% CI 1.080 to 1.192) were independent risk factors for determining COVID-19 associated mortality. CONCLUSIONS: COVID-19 is associated with a significant risk of morbidity and mortality in the population. Older age and higher white blood cell count were found to be independent risk factors for mortality.
BACKGROUND: The current coronavirus disease 2019 (COVID-19) is a public health emergency. In this study, we aimed to evaluate the risk factors for mortality in severe and critical COVID-19patients. METHODS: We performed a retrospective study of patients diagnosed with severe and critical COVID-19 from four hospitals in Wuhan, China, by evaluating the clinical characteristics and laboratory results, and using Cox proportional hazards model to assess the risk factors involved in disease progression. RESULTS: In total, 446 patients with COVID-19 were enrolled. The study indicated a high mortality rate (20.2%) in severe and critical COVID-19patients. At the time of admission, all patients required oxygen therapy, and 52 (12%) required invasive mechanical ventilation, of which 50 (96%) died. The univariate Cox proportional hazards model showed a white blood cell count of more than 10 × 109/L (HR 3.993,95%CI 2.469 to 6.459) that correlated with an increased mortality rate. The multivariable Cox proportional hazards model demonstrated that older age (HR 1.066, 95% CI 1.043 to 1.089) and higher white blood cell count (HR 1.135, 95% CI 1.080 to 1.192) were independent risk factors for determining COVID-19 associated mortality. CONCLUSIONS:COVID-19 is associated with a significant risk of morbidity and mortality in the population. Older age and higher white blood cell count were found to be independent risk factors for mortality.
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