OBJECTIVE: To compare baseline characteristics, clinical presentations and outcomes of patients with rheumatic conditions requiring hospitalization for coronavirus disease 2019 (COVID-19) who received chronic HCQ with those who did not receive chronic HCQ. METHODS: We identified all patients with a rheumatologic disease who were admitted with COVID-19 to two hospitals in New York City between 3 March 3 and 30 April 2020. Patients who received chronic HCQ prior to admission were matched 1:2 (±10 years of age) with patients who did not receive chronic HCQ. We compared demographics, comorbidities, HCQ dosages, concurrent medications, presentations and outcomes between the groups. RESULTS: There were 14 patients receiving HCQ and 28 matched control subjects. The median age of cases was 63 years [interquartile range (IQR) 43-73) and 60 years (IQR 41-75) for controls. Control subjects had a higher prevalence of pulmonary diseases (42.8%), diabetes (35.7%) and obesity (35.7%) than their case counterparts (28.6%, 14.3% and 7.1%, respectively). A higher proportion of cases than control subjects (50% vs 25%) reported the use of prednisone for their rheumatic conditions prior to admission. Despite these differences in baseline characteristics, univariate logistic regression revealed no statistically significant differences in the need for mechanical ventilation [OR 1.5 (95% CI 0.34, 6.38)] or in-hospital mortality [OR 0.77 (95% CI 0.13, 4.56)]. CONCLUSION: HCQ therapy in individuals with rheumatic conditions was not associated with less severe presentations of COVID-19 among hospitalized patients compared with individuals with rheumatic conditions not receiving HCQ.
OBJECTIVE: To compare baseline characteristics, clinical presentations and outcomes of patients with rheumatic conditions requiring hospitalization for coronavirus disease 2019 (COVID-19) who received chronic HCQ with those who did not receive chronic HCQ. METHODS: We identified all patients with a rheumatologic disease who were admitted with COVID-19 to two hospitals in New York City between 3 March 3 and 30 April 2020. Patients who received chronic HCQ prior to admission were matched 1:2 (±10 years of age) with patients who did not receive chronic HCQ. We compared demographics, comorbidities, HCQ dosages, concurrent medications, presentations and outcomes between the groups. RESULTS: There were 14 patients receiving HCQ and 28 matched control subjects. The median age of cases was 63 years [interquartile range (IQR) 43-73) and 60 years (IQR 41-75) for controls. Control subjects had a higher prevalence of pulmonary diseases (42.8%), diabetes (35.7%) and obesity (35.7%) than their case counterparts (28.6%, 14.3% and 7.1%, respectively). A higher proportion of cases than control subjects (50% vs 25%) reported the use of prednisone for their rheumatic conditions prior to admission. Despite these differences in baseline characteristics, univariate logistic regression revealed no statistically significant differences in the need for mechanical ventilation [OR 1.5 (95% CI 0.34, 6.38)] or in-hospital mortality [OR 0.77 (95% CI 0.13, 4.56)]. CONCLUSION: HCQ therapy in individuals with rheumatic conditions was not associated with less severe presentations of COVID-19 among hospitalized patients compared with individuals with rheumatic conditions not receiving HCQ.
Authors: Wesley H Self; Matthew W Semler; Lindsay M Leither; Jonathan D Casey; Derek C Angus; Roy G Brower; Steven Y Chang; Sean P Collins; John C Eppensteiner; Michael R Filbin; D Clark Files; Kevin W Gibbs; Adit A Ginde; Michelle N Gong; Frank E Harrell; Douglas L Hayden; Catherine L Hough; Nicholas J Johnson; Akram Khan; Christopher J Lindsell; Michael A Matthay; Marc Moss; Pauline K Park; Todd W Rice; Bryce R H Robinson; David A Schoenfeld; Nathan I Shapiro; Jay S Steingrub; Christine A Ulysse; Alexandra Weissman; Donald M Yealy; B Taylor Thompson; Samuel M Brown; Jay Steingrub; Howard Smithline; Bogdan Tiru; Mark Tidswell; Lori Kozikowski; Sherell Thornton-Thompson; Leslie De Souza; Peter Hou; Rebecca Baron; Anthony Massaro; Imoigele Aisiku; Lauren Fredenburgh; Raghu Seethala; Lily Johnsky; Richard Riker; David Seder; Teresa May; Michael Baumann; Ashley Eldridge; Christine Lord; Nathan Shapiro; Daniel Talmor; Thomas O’Mara; Charlotte Kirk; Kelly Harrison; Lisa Kurt; Margaret Schermerhorn; Valerie Banner-Goodspeed; Katherine Boyle; Nicole Dubosh; Michael Filbin; Kathryn Hibbert; Blair Parry; Kendall Lavin-Parsons; Natalie Pulido; Brendan Lilley; Carl Lodenstein; Justin Margolin; Kelsey Brait; Alan Jones; James Galbraith; Rebekah Peacock; Utsav Nandi; Taylor Wachs; Michael Matthay; Kathleen Liu; Kirsten Kangelaris; Ralph Wang; Carolyn Calfee; Kimberly Yee; Gregory Hendey; Steven Chang; George Lim; Nida Qadir; Andrea Tam; Rebecca Beutler; Joseph Levitt; Jenny Wilson; Angela Rogers; Rosemary Vojnik; Jonasel Roque; Timothy Albertson; James Chenoweth; Jason Adams; Skyler Pearson; Maya Juarez; Eyad Almasri; Mohamed Fayed; Alyssa Hughes; Shelly Hillard; Ryan Huebinger; Henry Wang; Elizabeth Vidales; Bela Patel; Adit Ginde; Marc Moss; Amiran Baduashvili; Jeffrey McKeehan; Lani Finck; Carrie Higgins; Michelle Howell; Ivor Douglas; Jason Haukoos; Terra Hiller; Carolynn Lyle; Alicia Cupelo; Emily Caruso; Claudia Camacho; Stephanie Gravitz; James Finigan; Christine Griesmer; Pauline Park; Robert Hyzy; Kristine Nelson; Kelli McDonough; Norman Olbrich; Mark Williams; Raj Kapoor; Jean Nash; Meghan Willig; Henry Ford; Jayna Gardner-Gray; Mayur Ramesh; Montefiore Moses; Michelle Ng Gong; Michael Aboodi; Ayesha Asghar; Omowunmi Amosu; Madeline Torres; Savneet Kaur; Jen-Ting Chen; Aluko Hope; Brenda Lopez; Kathleen Rosales; Jee Young You; Jarrod Mosier; Cameron Hypes; Bhupinder Natt; Bryan Borg; Elizabeth Salvagio Campbell; R Duncan Hite; Kristin Hudock; Autumn Cresie; Faysal Alhasan; Jose Gomez-Arroyo; Abhijit Duggal; Omar Mehkri; Andrei Hastings; Debasis Sahoo; Francois Abi Fadel; Susan Gole; Valerie Shaner; Allison Wimer; Yvonne Meli; Alexander King; Thomas Terndrup; Matthew Exline; Sonal Pannu; Emily Robart; Sarah Karow; Catherine Hough; Bryce Robinson; Nicholas Johnson; Daniel Henning; Monica Campo; Stephanie Gundel; Sakshi Seghal; Sarah Katsandres; Sarah Dean; Akram Khan; Olivia Krol; Milad Jouzestani; Peter Huynh; Alexandra Weissman; Donald Yealy; Denise Scholl; Peter Adams; Bryan McVerry; David Huang; Derek Angus; Jordan Schooler; Steven Moore; Clark Files; Chadwick Miller; Kevin Gibbs; Mary LaRose; Lori Flores; Lauren Koehler; Caryn Morse; John Sanders; Caitlyn Langford; Kristen Nanney; Masiku MdalaGausi; Phyllis Yeboah; Peter Morris; Jamie Sturgill; Sherif Seif; Evan Cassity; Sanjay Dhar; Marjolein de Wit; Jessica Mason; Andrew Goodwin; Greg Hall; Abbey Grady; Amy Chamberlain; Samuel Brown; Joseph Bledsoe; Lindsay Leither; Ithan Peltan; Nathan Starr; Melissa Fergus; Valerie Aston; Quinn Montgomery; Rilee Smith; Mardee Merrill; Katie Brown; Brent Armbruster; Estelle Harris; Elizabeth Middleton; Robert Paine; Stacy Johnson; Macy Barrios; John Eppensteiner; Alexander Limkakeng; Lauren McGowan; Tedra Porter; Andrew Bouffler; J. Clancy Leahy; Bennet deBoisblanc; Matthew Lammi; Kyle Happel; Paula Lauto; Wesley Self; Jonathan Casey; Matthew Semler; Sean Collins; Frank Harrell; Christopher Lindsell; Todd Rice; William Stubblefield; Christopher Gray; Jakea Johnson; Megan Roth; Margaret Hays; Donna Torr; Arwa Zakaria; David Schoenfeld; Taylor Thompson; Douglas Hayden; Nancy Ringwood; Cathryn Oldmixon; Christine Ulysse; Richard Morse; Ariela Muzikansky; Laura Fitzgerald; Samuel Whitaker; Adrian Lagakos; Roy Brower; Lora Reineck; Neil Aggarwal; Karen Bienstock; Michelle Freemer; Myron Maclawiw; Gail Weinmann; Laurie Morrison; Mark Gillespie; Richard Kryscio; Daniel Brodie; Wojciech Zareba; Anne Rompalo; Michael Boeckh; Polly Parsons; Jason Christie; Jesse Hall; Nicholas Horton; Laurie Zoloth; Neal Dickert; Deborah Diercks Journal: JAMA Date: 2020-12-01 Impact factor: 56.272
Authors: Alexandre B Cavalcanti; Fernando G Zampieri; Regis G Rosa; Luciano C P Azevedo; Viviane C Veiga; Alvaro Avezum; Lucas P Damiani; Aline Marcadenti; Letícia Kawano-Dourado; Thiago Lisboa; Debora L M Junqueira; Pedro G M de Barros E Silva; Lucas Tramujas; Erlon O Abreu-Silva; Ligia N Laranjeira; Aline T Soares; Leandro S Echenique; Adriano J Pereira; Flávio G R Freitas; Otávio C E Gebara; Vicente C S Dantas; Remo H M Furtado; Eveline P Milan; Nicole A Golin; Fábio F Cardoso; Israel S Maia; Conrado R Hoffmann Filho; Adrian P M Kormann; Roberto B Amazonas; Monalisa F Bocchi de Oliveira; Ary Serpa-Neto; Maicon Falavigna; Renato D Lopes; Flávia R Machado; Otavio Berwanger Journal: N Engl J Med Date: 2020-07-23 Impact factor: 91.245
Authors: Milena Gianfrancesco; Kimme L Hyrich; Jinoos Yazdany; Pedro M Machado; Philip C Robinson; Sarah Al-Adely; Loreto Carmona; Maria I Danila; Laure Gossec; Zara Izadi; Lindsay Jacobsohn; Patricia Katz; Saskia Lawson-Tovey; Elsa F Mateus; Stephanie Rush; Gabriela Schmajuk; Julia Simard; Anja Strangfeld; Laura Trupin; Katherine D Wysham; Suleman Bhana; Wendy Costello; Rebecca Grainger; Jonathan S Hausmann; Jean W Liew; Emily Sirotich; Paul Sufka; Zachary S Wallace Journal: Ann Rheum Dis Date: 2020-05-29 Impact factor: 19.103
Authors: Peter Horby; Marion Mafham; Louise Linsell; Jennifer L Bell; Natalie Staplin; Jonathan R Emberson; Martin Wiselka; Andrew Ustianowski; Einas Elmahi; Benjamin Prudon; Tony Whitehouse; Timothy Felton; John Williams; Jakki Faccenda; Jonathan Underwood; J Kenneth Baillie; Lucy C Chappell; Saul N Faust; Thomas Jaki; Katie Jeffery; Wei Shen Lim; Alan Montgomery; Kathryn Rowan; Joel Tarning; James A Watson; Nicholas J White; Edmund Juszczak; Richard Haynes; Martin J Landray Journal: N Engl J Med Date: 2020-10-08 Impact factor: 91.245
Authors: Parag Goyal; Justin J Choi; Laura C Pinheiro; Edward J Schenck; Ruijun Chen; Assem Jabri; Michael J Satlin; Thomas R Campion; Musarrat Nahid; Joanna B Ringel; Katherine L Hoffman; Mark N Alshak; Han A Li; Graham T Wehmeyer; Mangala Rajan; Evgeniya Reshetnyak; Nathaniel Hupert; Evelyn M Horn; Fernando J Martinez; Roy M Gulick; Monika M Safford Journal: N Engl J Med Date: 2020-04-17 Impact factor: 176.079