Laura A Woollett1, Elaine M Urbina2, Jessica G Woo3. 1. Department of Pathobiology and Molecular Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, United States. 2. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States; The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States. 3. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States; Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States. Electronic address: jessica.woo@cchmc.org.
Abstract
BACKGROUND: Previous studies report that first pregnancy is associated with persistent decreases in HDL-cholesterol (HDL-C) concentrations. OBJECTIVE: This study evaluated factors associated with declines in HDL-C concentration in parous and nulliparous young women. METHODS: This study leverages data from African-American and white women from the NHLBI Growth and Health Study. Parity-related changes in lipids, BMI and percent body fat were assessed longitudinally. A subset of primiparous and nulliparous women with paired lipid measurements were analyzed regarding changes in HDL-C concentrations. RESULTS: Among 870 women in longitudinal analyses, African-American women had higher parity (p<0.0001), with baseline measurements of each parity group being similar. HDL-C concentration decreased significantly and remained lower after the first pregnancy, while BMI and percent body fat increased with increasing parity. In the subset of 401 women, HDL-C concentration decreased among primiparous women (-4.81 ± 0.93 mg/dl), with no overall change in nulliparous (p = 0.003). In both groups, greater HDL-C concentration declines were independently associated with higher initial HDL-C concentration and greater increases in BMI (both p<0.0001). Among primiparous women, younger delivery age (p = 0.0001) and birth control use (p = 0.004) were associated with greater HDL-C concentration decline. Nulliparous white women's HDL-C concentration increased over time, with no change in African-American women (p = 0.008); no racial difference was seen in primiparous women. CONCLUSION: Persistent decreases in HDL-C concentration were associated with the first pregnancy, and were greater with higher initial HDL-C concentration. Racial differences in HDL-C concentration emerged over time in nulliparous women, but not primiparous women. Potential impacts of these findings on women's long-term cardiometabolic health should be evaluated.
BACKGROUND: Previous studies report that first pregnancy is associated with persistent decreases in HDL-cholesterol (HDL-C) concentrations. OBJECTIVE: This study evaluated factors associated with declines in HDL-C concentration in parous and nulliparous young women. METHODS: This study leverages data from African-American and white women from the NHLBI Growth and Health Study. Parity-related changes in lipids, BMI and percent body fat were assessed longitudinally. A subset of primiparous and nulliparous women with paired lipid measurements were analyzed regarding changes in HDL-C concentrations. RESULTS: Among 870 women in longitudinal analyses, African-American women had higher parity (p<0.0001), with baseline measurements of each parity group being similar. HDL-C concentration decreased significantly and remained lower after the first pregnancy, while BMI and percent body fat increased with increasing parity. In the subset of 401 women, HDL-C concentration decreased among primiparous women (-4.81 ± 0.93 mg/dl), with no overall change in nulliparous (p = 0.003). In both groups, greater HDL-C concentration declines were independently associated with higher initial HDL-C concentration and greater increases in BMI (both p<0.0001). Among primiparous women, younger delivery age (p = 0.0001) and birth control use (p = 0.004) were associated with greater HDL-C concentration decline. Nulliparous white women's HDL-C concentration increased over time, with no change in African-American women (p = 0.008); no racial difference was seen in primiparous women. CONCLUSION: Persistent decreases in HDL-C concentration were associated with the first pregnancy, and were greater with higher initial HDL-C concentration. Racial differences in HDL-C concentration emerged over time in nulliparous women, but not primiparous women. Potential impacts of these findings on women's long-term cardiometabolic health should be evaluated.
Authors: Erica P Gunderson; Rachel A Whitmer; Cora E Lewis; Charles P Quesenberry; Delia Smith West; Stephen Sidney Journal: J Womens Health (Larchmt) Date: 2005-12 Impact factor: 2.681
Authors: Alaina M Bever; Sunni L Mumford; Enrique F Schisterman; Lindsey Sjaarda; Neil J Perkins; Nicole Gerlanc; Elizabeth A DeVilbiss; Robert M Silver; Keewan Kim; Carrie J Nobles; Melissa M Amyx; Lindsay D Levine; Katherine L Grantz Journal: Sci Rep Date: 2020-01-28 Impact factor: 4.379