Zhu Liu1,2, Qingli Fan3, Shizheng Wu4, Yaqi Wan1,5, Yancheng Lei1. 1. Qinghai Provincial People's Hospital, Xining, China. 2. Qinghai University, Qinghai, China. 3. Qinghai Provincial People's Hospital, Xining, China. fql771017@126.com. 4. Qinghai Provincial People's Hospital, Xining, China. wushizheng2005@hotmail.com. 5. Key Laboratory of Application and Foundation for High Altitude Medicine Research in Qinghai Province (Qinghai Utah Loint Research Key Lab for High Altitude Medicine), Xining, China.
Abstract
BACKGROUND: The inflammatory response plays essential roles in the pathological process and prognosis of Parkinson's disease (PD). This research investigated the predictive value of the neutrophil to high-density lipoprotein ratio (NHR), neutrophil to lymphocyte ratio (NLR), and monocyte to high-density lipoprotein ratio (MHR) for PD. METHODS: Patients with PD (n = 98) were divided into three groups according to disease duration: < 6 years (n = 55), 6-10 years (n = 29) and > 10 years (n = 14). Based on the classification system of Hoehn and Yahr, grades 1 ~ 2.5 were considered early-stage PD (n = 44), and grades 3 ~ 5 were considered advanced-stage PD (n = 54). In addition, healthy subjects (n = 98) matched to the above PD patients in the same period were selected as the control group. Differences in the NHR, NLR, MHR and other indicators among the groups were evaluated. RESULTS: Smoking, drinking, the neutrophil count and the NHR and NLR were remarkably greater and hypertension, index of body mass, the lymphocyte count, and the levels of cholesterol in total, triglycerides, lipoprotein cholesterol with low density and uric acid were sharply lower in the PD group compared with in the control group. Analysis of multifactor logistic regression indicated that the NHR (odds ratio (adjusted OR) = 1.576, 95% CI: 1.053 ~ 2.358, P = 0.027) and NLR (adjusted OR = 1.734, 95% CI: 1.046 ~ 2.876, P = 0.033) were factors of risk for PD, while the MHR was not significantly correlated with PD. The areas under the receiver operating characteristic (ROC) curve (AUCs) for the prediction of PD by the NHR and NLR were 0.654 (95% CI: 0.583 ~ 0.721, P = 0.0001) and 0.69 (95% CI: 0.62 ~ 0.754, P < 0.0001), respectively, and the optimal cutoff values were 1.848 × 109/mmol and 2.62 × 109/mmol. Spearman's correlation analysis indicated that the NHR was correlated with the disease duration significantly negatively and that the MHR was positively correlated with disease severity. CONCLUSIONS: In summary, the NHR not only has strong predictive value for PD but is also closely related to disease duration. The NHR may be a better prediction for the long-period clinical results in PD patients than the MHR and NLR. TRIAL REGISTRATION: Clinical medical reserach center project of Qinghai Province (2017-SF-L1).
BACKGROUND: The inflammatory response plays essential roles in the pathological process and prognosis of Parkinson's disease (PD). This research investigated the predictive value of the neutrophil to high-density lipoprotein ratio (NHR), neutrophil to lymphocyte ratio (NLR), and monocyte to high-density lipoprotein ratio (MHR) for PD. METHODS:Patients with PD (n = 98) were divided into three groups according to disease duration: < 6 years (n = 55), 6-10 years (n = 29) and > 10 years (n = 14). Based on the classification system of Hoehn and Yahr, grades 1 ~ 2.5 were considered early-stage PD (n = 44), and grades 3 ~ 5 were considered advanced-stage PD (n = 54). In addition, healthy subjects (n = 98) matched to the above PDpatients in the same period were selected as the control group. Differences in the NHR, NLR, MHR and other indicators among the groups were evaluated. RESULTS: Smoking, drinking, the neutrophil count and the NHR and NLR were remarkably greater and hypertension, index of body mass, the lymphocyte count, and the levels of cholesterol in total, triglycerides, lipoprotein cholesterol with low density and uric acid were sharply lower in the PD group compared with in the control group. Analysis of multifactor logistic regression indicated that the NHR (odds ratio (adjusted OR) = 1.576, 95% CI: 1.053 ~ 2.358, P = 0.027) and NLR (adjusted OR = 1.734, 95% CI: 1.046 ~ 2.876, P = 0.033) were factors of risk for PD, while the MHR was not significantly correlated with PD. The areas under the receiver operating characteristic (ROC) curve (AUCs) for the prediction of PD by the NHR and NLR were 0.654 (95% CI: 0.583 ~ 0.721, P = 0.0001) and 0.69 (95% CI: 0.62 ~ 0.754, P < 0.0001), respectively, and the optimal cutoff values were 1.848 × 109/mmol and 2.62 × 109/mmol. Spearman's correlation analysis indicated that the NHR was correlated with the disease duration significantly negatively and that the MHR was positively correlated with disease severity. CONCLUSIONS: In summary, the NHR not only has strong predictive value for PD but is also closely related to disease duration. The NHR may be a better prediction for the long-period clinical results in PDpatients than the MHR and NLR. TRIAL REGISTRATION: Clinical medical reserach center project of Qinghai Province (2017-SF-L1).
Entities:
Keywords:
Disease duration; Monocyte to high-density lipoprotein ratio; Neutrophil to ratio of lipoprotein with high density; Parkinson’s disease; Ratio of neutrophil to lymphocyte; Severity
Authors: Valerie Joers; Gunasingh Masilamoni; Doty Kempf; Alison R Weiss; Travis M Rotterman; Benjamin Murray; Gul Yalcin-Cakmakli; Ronald J Voll; Mark M Goodman; Leonard Howell; Jocelyne Bachevalier; Stefan J Green; Ankur Naqib; Maliha Shaikh; Phillip A Engen; Ali Keshavarzian; Christopher J Barnum; Jonathon A Nye; Yoland Smith; Malú G Tansey Journal: Neurobiol Dis Date: 2020-07-24 Impact factor: 5.996
Authors: Rudie Kortekaas; Klaus L Leenders; Joost C H van Oostrom; Willem Vaalburg; Joost Bart; Antoon T M Willemsen; N Harry Hendrikse Journal: Ann Neurol Date: 2005-02 Impact factor: 10.422
Authors: Veselin Grozdanov; Luc Bousset; Meike Hoffmeister; Corinna Bliederhaeuser; Christoph Meier; Karine Madiona; Laura Pieri; Martin Kiechle; Pamela J McLean; Jan Kassubek; Christian Behrends; Albert C Ludolph; Jochen H Weishaupt; Ronald Melki; Karin M Danzer Journal: Ann Neurol Date: 2019-08-15 Impact factor: 10.422
Authors: Sara Konstantin Nissen; Kalpana Shrivastava; Claudia Schulte; Daniel Erik Otzen; David Goldeck; Daniela Berg; Holger Jon Møller; Walter Maetzler; Marina Romero-Ramos Journal: Mov Disord Date: 2019-08-26 Impact factor: 10.338
Authors: Elizabeth M Kline; Madelyn C Houser; Mary K Herrick; Philip Seibler; Christine Klein; Andrew West; Malú G Tansey Journal: Mov Disord Date: 2020-12-14 Impact factor: 10.338
Authors: Scott T Chiesa; Marietta Charakida; Eve McLoughlin; Helen C Nguyen; Georgios Georgiopoulos; Laura Motran; Yesmino Elia; M Loredana Marcovecchio; David B Dunger; R Neil Dalton; Denis Daneman; Etienne Sochett; Farid H Mahmud; John E Deanfield Journal: Eur Heart J Date: 2019-11-14 Impact factor: 29.983