Ming Liu1, Ya-Jun Luo1, Han-Ying Gu1, Yi-Ming Wang1, Man-Hua Liu1, Kai Li1, Jiao Li1, Sheng Zhuang1, Yun Shen1, Hong Jin1, Jing Chen1, Cheng-Jie Mao2, Chun-Feng Liu1,3. 1. Department of Neurology and Suzhou Clinical Research Center of Neurological Diseases, the Second Affiliated Hospital of Soochow University, Suzhou, 215004, Jiangsu Province, China. 2. Department of Neurology and Suzhou Clinical Research Center of Neurological Diseases, the Second Affiliated Hospital of Soochow University, Suzhou, 215004, Jiangsu Province, China. drchengjiemao@163.com. 3. Department of Neurology, Suqian First Hospital, Suqian, China.
Abstract
BACKGROUND: The clinical characteristics of Parkinson's disease (PD) differ between men and women, and late- and early-onset patients, including motor symptoms and some nonmotor symptoms, such as cognition, anxiety, and depression. OBJECTIVE: To explore the features of excessive daytime sleepiness (EDS) and night-time sleep quality in PD patients of different sexes and age at onset (AAO). METHODS: Demographic data and clinical characteristics of 586 PD patients were collected. Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality Index (PSQI) were used to investigate the daytime drowsiness and nocturnal sleep. Multivariate logistic regression analysis was used to explore the risk factors of EDS and poor night-time sleep quality. RESULTS: Sleep disorders were common in PD patients. EDS was more prominent in men than in women. There was no significant difference in ESS scores between late-onset PD (LOPD) and early-onset PD. LOPD patients had a higher probability of poor night-time sleep quality. Male sex, disease duration, and depression were risk factors for EDS. In all patients of both sexes and all AAO, depression was a risk factor for poor night-time sleep. CONCLUSION: More attention should be paid to sleep disorders of PD patients, especially male LOPD patients. Depression is a common risk factor for EDS and poor sleep quality in PD patients.
BACKGROUND: The clinical characteristics of Parkinson's disease (PD) differ between men and women, and late- and early-onset patients, including motor symptoms and some nonmotor symptoms, such as cognition, anxiety, and depression. OBJECTIVE: To explore the features of excessive daytime sleepiness (EDS) and night-time sleep quality in PDpatients of different sexes and age at onset (AAO). METHODS: Demographic data and clinical characteristics of 586 PDpatients were collected. Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality Index (PSQI) were used to investigate the daytime drowsiness and nocturnal sleep. Multivariate logistic regression analysis was used to explore the risk factors of EDS and poor night-time sleep quality. RESULTS:Sleep disorders were common in PDpatients. EDS was more prominent in men than in women. There was no significant difference in ESS scores between late-onset PD (LOPD) and early-onset PD. LOPD patients had a higher probability of poor night-time sleep quality. Male sex, disease duration, and depression were risk factors for EDS. In all patients of both sexes and all AAO, depression was a risk factor for poor night-time sleep. CONCLUSION: More attention should be paid to sleep disorders of PDpatients, especially male LOPD patients. Depression is a common risk factor for EDS and poor sleep quality in PDpatients.
Entities:
Keywords:
Age at onset; Excessive daytime sleepiness; Nocturnal sleep quality; Parkinson’s disease; Sex difference
Authors: Michal Lubomski; R Louise Rushworth; Will Lee; Kelly L Bertram; David R Williams Journal: J Clin Neurosci Date: 2014-04-24 Impact factor: 1.961
Authors: Panagiotis Bargiotas; Maria Ntafouli; M Lenard Lachenmayer; Paul Krack; W M Michael Schüpbach; Claudio L A Bassetti Journal: J Neurol Sci Date: 2019-02-20 Impact factor: 3.181