| Literature DB >> 33874871 |
S P Simna1, Zongchao Han1,2,3.
Abstract
Gene therapy has made significant development since the commencement of the first clinical trials a few decades ago and has remained a dynamic area of research regardless of obstacles such as immune response and insertional mutagenesis. Progression in various technologies like next-generation sequencing (NGS) and nanotechnology has established the importance of non-- coding segments of a genome, thereby taking gene therapy to the next level. In this review, we have summarized the importance of non-coding elements, highlighting the advantages of using full- length genomic DNA loci (gDNA) compared to complementary DNA (cDNA) or minigene, currently used in gene therapy. The focus of this review is to provide an overview of the advances and the future of potential use of gDNA loci in gene therapy, expanding the therapeutic repertoire in molecular medicine. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Entities:
Keywords: Gene therapy; cDNA; gene expression; genomic DNA; non-coding DNA; polygenic diseases
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Year: 2022 PMID： 33874871 PMCID： PMC9335901 DOI： 10.2174/1566523221666210419090357
Source DB: PubMed Journal: Curr Gene Ther ISSN： 1566-5232 Impact factor: 4.676